Angela Hyde

Dr Hyde is a Medical Oncologist with the Cancer Care Program and Clinician Scientist with the Pathology and Laboratory Medicine Program at NL Health Services. She is also the Medical Director of Clinical Services for the Centre for Translational Genomics.  She is a Clinical Assistant Professor in both the Disciplines of Oncology and Laboratory Medicine at Memorial University, and is the Medical Oncology Clerkship Lead. She completed her MD and PhD (Cancer Genetics) at Memorial University, and is FRCPC certified in Internal Medicine (residency completed at Memorial University) and Medical Oncology (residency completed at the University of Ottawa).

Her clinical focus is gastrointestinal malignancies and hereditary cancer syndromes. She is the provincial Medical Oncology Gastrointestinal Site Lead, and is establishing a longitudinal Hereditary Cancer Clinic. She is co-lead of numerous clinical and research initiatives relating to cancer genetics/genomics and hereditary cancer syndromes. She sits on multiple local and national committees with goal of advancing precision medicine in oncology.  

Current Professional Activities and Committees

National and International:

• National Biomarker Advisory Panel, Invited Member, Canada’s Drug Agency (CDA-AMC)
• Pan-Canadian Cancer Genomics Community of Practice, Invited Member (CDA-AMC, Canadian Association of Provincial Cancer Agencies, and Canadian Partnership Against Cancer)
• Clinical Cancer Genomics Community of Practice, City of Hope Cancer Institute, California, USA
• Drug Access in Canada: Understanding the System, Invited Panel Member, CDA-AMC
• Canadian Cancer Trials Group, Gastrointestinal Disease Site Lead for Newfoundland

Provincial and Regional:

• Provincial Laboratory Formulary Advisory Panel, Co-Chair
• Provincial Oncology Drug Committee, Member
• Provincial Systemic Antineoplastic Therapy Advisory Committee, Member
• Pathology-Oncology Committee, Member
• Atlantic Cancer Consortium Patient Advisory Committee, Terry Fox Research Institute Marathon of Hope
• Cancer Triage Panel, Provincial Medical Genetics Program
• Atlantic Precision Medicine Conference, Steering Committee Member

Selected Awards

• Medical Research Fund (MRF) Research Grant (2025), Co-Investigator, Integrating Whole Genome Sequencing and DNA Methylation Profiling to Uncover Genetics and Epigenetic Biomarkers of Colorectal Cancer in Newfoundland and Labrador
• Health Professionals Grant, NL Support (2022) Co-Principal Investigator, Assessing the Readiness of Newfoundland and Labrador Oncology Nurses to Provide Patient-Centred Cancer Care and Prevention Informed by Genetics and Genomics: A Mixed-Methods Study
• Quick Start Grant (2022) Supervisory Committee Member of Principal Investigator, Building Partnerships with the Cancer Care Workforce to Enhance Cancer Care through Genetic and Genomic Competency Development
• Physician Leadership Bursary (2021), Newfoundland and Labrador Medical Association
• The Walter and Jessie Boyd and Charles Scriver MD/PhD Studentship Award (2003-2010) 

Selected Publications

Puddester, R., Hyde, A., Etchegary, H., Stevens, K., Pike, A., Maddigan, J. Oncology Nurses’ Readiness to Implement Genomics-Informed Care: A Descriptive, Cross-Sectional Study in a Canadian Province. Canadian Oncology Nursing Journal 2026;36(1):45-54 

Savas, S., Skardasi, G., Curtis, A., Martinez, M., King, J., Corbett, C., Donovan Whitty, J., LeBlanc, G., Pausche, B., Coish, J., Hyde, A., and MacInnis, C. Patient Advisory Committee Engagement in a Precision Medicine-Focused Public Oncology Conference: Case Reports of Lessons Learned. Journal of. Primary Care and Community Health. 2026;17

Farncombe, K., Sobotka, J., Aronson, M., Basik, M., Bombard, Y., Born, L., Cheifetz, R., Clausen, M., Coburn, N., Dawson, L., Doria, A., Elbanna, K., Etchegary, H., Foulkes, W., Hessels, C., Hyde, A., Kazazian, K., Kinnaird, A., Koch, C., Laframboise, S., Lerner-Ellis, J., Lheureux, S., Malkin, D., Metser, U., Penney, L., Ridd, S., Schrader, K., Tiano, T., Tone, A., Veit-Haibach, P., Wong, S., Xu, W., Pugh, T., and Kim, R.  Non-invasive screening in hereditary cancer: a randomized controlled trial to test cell-free DNA-based early detection in the CHARM consortium. European Journal of Human Genetics. 2026; https://doi.org/10.1038/s41431-026-02014-z

Savas, S., Skardasi, G., Curtis, A., Pausche, B., Coish, J., King, J., Corbett, C., Martinez, M., Whitty, J., Jennings, S., MacInnis, C., and Hyde, A. Cancer, precision medicine, and Atlantic Canada: A priority setting exercise by the Atlantic Cancer Consortium Patient Advisory Committee. Discover Health Systems. 2025; 4(27)

Aronson, M, Palma, L., Semotiuk, K., Nuk, J., Pollett, A., Singh, H., Rothenmund, H., Racher, H., Jessen, J., Paulter, S., Rusnak, A., Rutka, M., Etchegary, H., Tiano, T., Kaurah, P., Dawson, L., Hawrysh, A., Ward, T., Bedard, A., Sheffield, B., Lerner-Ellis, J., Jacob, K., Ferguson, S., Kim, C., Chamberlain, E., Dornan, K., Waldman, L., Holter, S., Horte, J., Hyde, A., Kwon, J., MacMillan, A., O’Loughlin, M., Tabori, U., Gallinger, S., and Kim, R. Canadian Consensus for the Assessment and Testing of Lynch Syndrome. J. Med Genet. 2025;62:326-334

Leigh, J., Ahmed, A., Aubin, F., Berry, S., Boucher, M., Campeau, MP., Colwell, B., Connors, S., Corbett, J., Dadwal, S., Dudani, S., Elimova, E., Falkson, C., Galvis, L., Goel, R., Gotfrit, J., Hyde, A., Febbraro, M., Laidley, D., Locke, G., Mahmud, A., Megid, TBC., Michael, J., Nair, V., Quigley, S., Ramjeesingh, R., Samimi, S., Seal, M., Snow, S., Spadafora, S., Stuckless, T., Wilson. B., Asmis, T., Goodwin, R., and Vickers, M. Eastern Canadian Gastrointestinal Cancer Consensus Conference 2024. Current Oncology. 2025; 32(3):175 

Puddester, R., Francis, V., Warren, M., Pike, A., Maddigan, J., Hyde, A., Stevens, K., and Etchegary, H. “Anybody who can clarify or humanize the experience would be such a help”: An interpretive description of perceptions of genomic health and nursing care in individuals with cancer predisposition syndromes. European Journal of Oncology Nursing. 2025; 74:102766 

Gotfrit,J., Goodwin, R., Asmis, T., Hyde, A.J., Alcindor,T., Aubin, F., Berry, S., Bossé,D., Brown, C., Burkes,R., Burnell, M., Colwell, B., Corbett, J., Craswell, J., Daaboul, N., Doherty, M., Fleming, D.A.B., Galvis, L., Goel, R., Harb, M., Jeyakumar, A., Jonker,D., Kennedy, E., Lock, M., Mahmud, A., McCrea, P.H., Nair, V., Nassabein, R., Nessim, C., Ramjeesingh, R., Raza, M., Saliba, W., Samimi, S., Singh, S., Snow, S., Tehfé, M., Thirlwell, M., Valdes,M., Welch, S., and Vickers, M. Eastern Canadian Gastrointestinal Cancer Consensus Conference 2019. Current Oncology. 2021; 28(5):1988-2006

A. J. Hyde, R. Nassabein, A. AlShareef, D. Armstrong, S. Babak, S. Berry, D. Bossé, E. Chen, B. Colwell, C. Essery, R. Goel, R. Goodwin, S. Gray, N. Hammad, A. Jeyakuymar, D. Jonker, P. Karanicolas, N. Lamond, R. Letourneau, J. Michael, N. Patil, E. Powell, R. Ramjeesingh, W. Saliba, R. Singh, S. Snow, T. Stuckless, S. Tadros, M. Tehfé, M. Thana, M. Thirlwell, M. Vickers, K. Virik, S. Welch, and T. Asmis. Eastern Canadian Gastrointestinal Cancer Consensus Conference 2018. Current Oncology. 2019; 26(5):e665-e681

McGee, S.F., AlGhareeb, W., Ahmad, C.H., Armstrong, D., Babak, S., Berry, S., Biagi, J., Booth, C., Bossé, D., Champion, P., Colwell, B., Finn, N., Goel, R., Gray, S., Green, J., Harb, M., Hyde, A., Jeyakumar, A., Jonker, D., Kanagaratnam, S., Kavan, P., MacMillan, A., Muinuddin, A., Patil, N., Porter, G., Powell, E., Ramjeesingh, R., Raza, M., Rorke, S., Seal, M., Servidio-Italiano, F., Siddiqui, J., Simms, J., Smithson, L., Snow, S., St-Hilaire, E., Stuckless, T., Tate, A., Tehfe, M., Thirlwell, M., Tsvetkova, E., Valdes, M., Vickers, M., Virik, K., Welch, S., Marginean, C., Asmis, T. Eastern Canadian Colorectal Cancer Consensus Conference 2017. Current Oncology. 2018; 25(4):262-274

Dan,L., Werdyani,S., Xu,J., Shestopaloff,K., Hyde,A., Dicks,E., Younghusband,B., Green,J., Parfrey,P., Xu,W., Savas,S. No associations of a set of SNPs in the Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinase (MMP) genes with survival of colorectal cancer patients. Cancer Medicine. 2016; 5(9):2221-21 

Haja Mohideen, A.M., Hyde, A., Squires, J., Wang, J., Dicks, E., Younghusband, B., Parfrey, P., Green, R., Savas, S. Examining the polymorphisms in the hypoxia pathway genes in relation to outcome in colorectal cancer. PLoS One. 2014; 9(11);e113513

Negandhi, A.A., Hyde, A., Dicks, E., Pollett, W., Younghusband, H.B., Parfrey, P., Green, R.C., Savas, S. MTHFR Glu429Ala and ERCC5 His46His polymorphisms are associated with prognosis in colorectal cancer patients: Analysis of two independent cohorts from Newfoundland. PLoS One. 2013; 8(4):e61469.

Savas, S., Hyde, A, Stuckless, S.N., Parfrey, P., Younghusband, H.B., Green, R. Serotonin transporter gene (SLC6A4) variations are associated with poor survival in colorectal cancer patients. PLOS One. 2012; 7(7):e38953.

Connor, J.J., Hyde, A.J.. Dr. Nigel Rusted, a CMAJ centenary reader. Canadian Medical Association Journal. 2011; 183(7):753-754. 

Hyde, A., Fontaine, D., Stuckless, S., Green, R., Pollett, A., Simms, M., Sipahimalani, P., Parfrey, P., Younghusband, B. A histology-based model for predicting microsatellite instability in colorectal cancers. American Journal of Surgical Pathology. 2010; 34(12):1820-9.

Wish, T.A., Hyde, A.J., Parfrey, P.S., Green, J.S., Younghusband, H.B., Simms, M.I., Fontaine, D.G., Dicks, E.L., Stuckless, S.N., Gallinger, S., McLaughlin, J.R., Woods, M.O., Green, R.C. Increased cancer predisposition in family members of colorectal cancer patients harboring the p.V600E BRAF mutation: a population-based study. Cancer Epidemiology Biomarkers and Prevention. 2010; 19(7):1831-9.

Woods, M.O., Hyde, A.J., Curtis, F.K., Stuckless, S., Green, J.S., Pollett, A.F., Robb, J.D., Green, R.C., Croitoru, M.E., Careen, A., Chaulk, J.A., Jegathesan, J., McLaughlin, J.R., Gallinger, S.S., Younghusband, H.B., Bapat, B.V., Parfrey, P.S. High frequency of hereditary colorectal cancer in Newfoundland likely involves novel susceptibility genes. Clinical Cancer Research. 2005; 11(19 Pt 1):6853-61.