Fei-yu Han

Associate Professor of Laboratory Medicine (Cytogenetics) Associate Professor of Cytogenetics from Lab Medicine MD (Henan), FCCMG

Lab Medicine

Research Interest

1. Chromosome aberrations in patients with mental retardation;2. Chromosome aberrations in Hematology malignancy and solid tumor.

Recent Publications

Zhi-Yuan Xu, Martin Loignon, Fei-Yu Han, Lawrence Panasci, and Raquel Aloyz (2005) Xrcc3 Induces Cisplatin Resistance by Stimulation of Rad51-Related Recombinational Repair, S-Phase Checkpoint Activation, and Reduced Apoptosis
J Pharmacol Exp Ther 314: 495-505.

Ciu J, Randell E, Renou J, Sun G., Ban Y, Han F-Y and Xie Y-G.(2004) Gender Dependent association of Thrombospondin-4 A387P polymorphism with Myocardial infarction. Arteriosclerosis, Thrombosis, and Vascular Biology. Nov; 24 (11):e183-4.

Aloyz R, Xu ZY, Bello V, Bergeron J, Han F-Y, Yan Y, Malapetsa A, Alaoui-Jamali MA, Duncan AM, Panasci L. (2002) Regulation of cisplatin resistance and homologous recombinational repair by the TFIIH subunit XPD. Cancer Res.1; 62(19):5457-62.

Peyrard M, Seroussi E, Sandberg-Nordqvist AC, Xie YG, Han F-Y, Fransson I, Collins J, Dunham I, Kost-Alimova M, Imreh S, Dumanski JP (1999) The human LARGE gene from 22q12.3-q13.1 is a new, distinct member of the glycosyltransferase gene family.Proc Natl Acad Sci U S A. Jan 19; 96(2):598-603

Xie Y-G, Rochefort D, Brais B, Howard H, Han FY, Gou LP, Maciel P, The BT, Larsson C, Rouleau GA (1998) Restriction map of a YAC and cosmid contig encompassing the oculopharyngeal muscular dystrophy candidate region on chromosome 14q11.2-q13.Genomics 1;52(2):201-4

Lafrenière RG; Kibar Z; Rochefort DL; Han F-Y; Fon EA; Dubé MP; Kang X; Baird S; Korneluk RG; Rommens JM; Rouleau GA (1997)Genomic structure of the human GT334 (EHOC-1) gene mapping to 21q22.3. Gene, 198:1-2, 313-21

Lafreniere R, Rochefort D. Kibar Z, Fon E, Han F-Y, Cochius J, Kang X, Baird S, Korneluk R, Andermann E, Rommens J, Rouleau G (1996) Isolation and characterization of GT335, a novel human gene conserved in Escherichia Coli and mapping to 21q22.3.Genomics 38: 264 -272

Ruttledge MH, Andermann AA, Phelan CM, Claudio JO, Han FY, Chretien N, Rangaratnam S, MacCollin M, Short P, Parry D, Michels V, Riccardi VM, Weksberg R, Kitamura K, Bradburn JM, Hall BD, Propping P, Rouleau GA (1996) Type of mutation in the neurofibromatosis type 2 gene (NF2). Am J Hum Genet 59(2):331-342

Rooke K., Figlewicz DA. , Han F-Y., and Rouleau GA.(1996) Analysis of the ksp repeat of the neurofilament heavy subunit in familial amyotrophic lateral sclerosis. Neurology 46: 789-790.

Pramatarova A., Figlewicz DA., Krizus, A., Han F-Y., Ceballos-Picot I., Nicole A., Dib M., Meininger V., Brown RH., Rouleau GA., (1995) Identification of new mutations in the Cu/Zn superoxide dismutase gene of patients with familial amyotrophic lateral sclerosis. American Journal of Human Genetics 56: 592-6.

Wang Y-T., Bajalica S., Han F-Y. Wang Z-C., Bui T-H., and Xie Y-G. (1994) Direct and Inverted Reciprocal Chromosome Insertions between Chromosome 7 and 14 in a Woman with Recurrent Miscarriages. American Journal of Medical Genetics 52: 349-351

Xie Y-G., Han F-Y., Bajalica S., Blennow E., Kristoffersson U., Dumanski J. P., and M. Nordenskjöld (1994) Identification, characterisation and clinical applications of cosmids from the telomeric and centromeric regions of the long arm of chromosome 22. Human Genetics 94: 339-345.

Ruttledge MH., Xie Y-G. , Han F-Y., Giovannini M., Janson M., Fransson I., Werelius B., Delattre O., Thomas G., Evans G., and Dumanski JP. (1994) Physical Mapping of the NF2/Meningioma Region on Human Chromosome 22q12. Genomics 19: 52-59.

Ruttledge, M. H., Xie Y-G., Han F-Y., Peyrard M., Collins VP., Nordenskjöld M., and J. P. Dumanski (1994) Deletions on chromosome 22 in sporatic meningioma. Genes, chromosomes & Cancer 10: 122-130

Peyrard, M, Fransson, I., Xie, Y-G., Han, F-Y., Ruttledge, MH., Swahn, S., Collins JE., Dunham, I., Collins, VP., Dumanski, JP., (1994) Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene. Human Molecular Genetics 3: 1393-9.

Abstracts

Cui J., Randell E. Renouf J , Sun G., Han F-Y, Green R. and Y-G Xie (2005) The Impact of Factor XIII Polymorphisms, FXIIIa T204P, P506L and Factor XIIIb Polymorphism H95A, on Myocardial Infarction. Subunit Deficiency in Newfoundland population. International Society of Thrombosis and Haemostasis XXth Congress (Sydney, August 2005)

J. Xu, T. Heshka, D. Whelan, J-X. Cui, F-Y. Han, Y-G. Xie (2004) Molecular Cytogenetics characterization of trisomy 13/trisomy 18 mixoploidy in a boy with moderate clinical features. Post presentation, Annual Meeting of American Society Human Genetics (Toronto, Oct. 2004)

Ciu J, Randell E, Renou J, Sun G., Ban Y, Han F-Y and Xie Y-G. (2004) Gender Dependent association of Thrombospondin-4 A387P polymorphism with Myocardial infarction. Post presentation, Annual Meeting of American Society Human Genetics (Toronto, Oct. 2004)

Han F-Y, Russell L, Morel C and Duncan A (2003) Detection of a cryptic subtelomeric insertion in a child with global development delay. America Society Human Genetics 53rd Annual Meeting (LA, USA, 2003)

Xie Y-G, Brais B, Maciel P, Lafreniere R, Han F-Y, Gao L-P, Larsson C, Rouleau G (1995) YAC and cosmid contig and restriction mapping of OPMD region on chromosome 14q. American Journal Human Genetics, 59: A315

Xie Y-G, Brais B, Maciel P, Lafreniere R, Han F-Y, Gao L-P, Catharina Larsson, Rouleau G Rouleau G (1995) Physical mapping of the oculopharyngeal muscular dystrophy (OPMD) region which encompasses the cardiac a and b myosin heavy chain genes on chromosome 14q. Abstract Book of The First international symposium on oculopharyngeal muscular dystrophy pp7.

Brais B, Xie Y-G, Han F-Y, Fardeau M, Tomé F, Buttler-Browne G and Rouleau G (1995) Evaluation of candidate genes. Abstract Book of The First international symposium on oculopharyngeal muscular dystrophy pp7.