Faculty A-Z

Robert Gendron
Professor of Cancer/Cardiovascular Biology, and Cross Appointment with Oncology Ph.D., McGill UniversityBioMedical Sciences Oncology
709-864-3359 / 709-864-6005
Address:
Email: rgendron@mun.ca
BioMedical Sciences Faculty of Medicine Memorial University of Newfoundland 300 Prince Philip Drive St. John's, NL, Canada A1B 3V6
With a diverse background in immunology, developmental biology, cancer biology, vascular biology and visual science, I have sustained a number of research programs in basic biomedical studies of health and disease for over 25 years. Much of this work would not be possible without a number of expert collaborators in the biomedical and clinical sciences. Most recently, in work funded by Natural Science and Engineering Research Council of Canada, my research has focused on unique anatomical and functional features of the visual systems of North Atlantic marine teleosts. Knowledge of how these systems might be important to the health and survival of these animals is relevant to vision biology in general and to ocean health on a broader scale. Collaboration has been critically important to this multidisciplinary work and I am fortunate to have access to the infrastructure, resources and expert teams at Department of Ocean Science and the Dr. Joe Brown Aquatic Research Building of Memorial University. Finally, the training and career development of new young scientists through graduate training programs remains a key aspect of my research programs.
Over more than two decades at Memorial University, I have led or participated in a number of research infrastructure grant awards from Atlantic Canada Opportunities Agency and Canada Foundation for Innovation.
In addition to graduate teaching and training in the Bioscience of Health and Disease Group, I teach in the Undergraduate Medical Education Program of Faculty of Medicine, in the subspecialty training program in Medical Oncology which is accredited by the Royal College of Physicians and Surgeons of Canada and in the Faculty of Medicine’s 310A Human Physiology Course for Non-Medical Students at Memorial University. I currently serve as Co-Coordinator of the Bioscience of Health and Disease Graduate Training Program, as the Undergraduate Content Lead (UCL) for Histology and as the UCL for Ophthalmology in the Undergraduate Medical Education Program in the Faculty of Medicine.
Publications:
Gendron RL, Hyde T, Paradis H, Cao T, Machimbirike VI, Segovia C, Vasquez I, Ghasemieshkaftaki M, Scapigliati G, Boyce D, Santander J. Fish Shellfish Immunol. 2022 Sep;128:523-535. doi: 10.1016/j.fsi.2022.08.023. Epub 2022 Aug 23. PMID: 35998868 |
McDonald J, Paradis H, Bartellas M, Gendron RL. Mol Vis. 2021 Mar 31;27:117-124. eCollection 2021. PMID: 33907367 Free PMC article. |
CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues. Gendron RL, Paradis H, Ahmad R, Kao K, Boyce D, Good WV, Kumar S, Vasquez I, Cao T, Hossain A, Chakraborty S, Valderrama K, Santander J. Front Immunol. 2020 Nov 20;11:576897. doi: 10.3389/fimmu.2020.576897. eCollection 2020. PMID: 33329544 Free PMC article. |
Paradis H, Ahmad R, McDonald J, Boyce D, Gendron RL. J Fish Dis. 2019 Oct;42(10):1401-1408. doi: 10.1111/jfd.13065. Epub 2019 Aug 8. PMID: 31393016 |
Ahmad R, Paradis H, Boyce D, McDonald J, Gendron RL. J Fish Biol. 2019 Feb;94(2):297-312. doi: 10.1111/jfb.13892. Epub 2019 Jan 21. PMID: 30565257 |
Clow KA, Short CE, Hall JR, Gendron RL, Paradis H, Ralhan A, Driedzic WR. J Exp Biol. 2016 Sep 1;219(Pt 17):2763-73. doi: 10.1242/jeb.141721. Epub 2016 Jul 8. PMID: 27401755 |
Tubedown regulation of retinal endothelial permeability signaling pathways. Ho N, Gendron RL, Grozinger K, Whelan MA, Hicks EA, Tennakoon B, Gardiner D, Good WV, Paradis H. Biol Open. 2015 Jul 3;4(8):970-9. doi: 10.1242/bio.010496. PMID: 26142315 Free PMC article. |
Osmotic pressure-adaptive responses in the eye tissues of rainbow smelt (Osmerus mordax). Gendron RL, Armstrong E, Paradis H, Haines L, Desjardins M, Short CE, Clow KA, Driedzic WR. Mol Vis. 2011;17:2596-604. Epub 2011 Oct 5. PMID: 22025894 Free PMC article. |
Loss of tubedown expression as a contributing factor in the development of age-related retinopathy. Gendron RL, Laver NV, Good WV, Grossniklaus HE, Miskiewicz E, Whelan MA, Walker J, Paradis H. Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5267-77. doi: 10.1167/iovs.09-4527. Epub 2010 May 12. PMID: 20463314 |
Paradis H, Islam T, Tucker S, Tao L, Koubi S, Gendron RL. J Cell Sci. 2008 Jun 15;121(Pt 12):1965-72. doi: 10.1242/jcs.028597. Epub 2008 May 21. PMID: 18495841 |
Genomics and proteomics of retinopathy of prematurity: DNA-based prevention and treatment. Good WV, Gendron RL. Br J Ophthalmol. 2007 Dec;91(12):1577. doi: 10.1136/bjo.2007.124404. PMID: 18024806 Free PMC article. |
Martin DT, Gendron RL, Jarzembowski JA, Perry A, Collins MH, Pushpanathan C, Miskiewicz E, Castle VP, Paradis H. Clin Cancer Res. 2007 Mar 1;13(5):1480-7. doi: 10.1158/1078-0432.CCR-06-1716. PMID: 17332292 |
Tubedown-1 (Tbdn-1) suppression in oxygen-induced retinopathy and in retinopathy of prematurity. Gendron RL, Good WV, Miskiewicz E, Tucker S, Phelps DL, Paradis H. Mol Vis. 2006 Feb 22;12:108-16. PMID: 16518308 |
Retinopathy of prematurity: gone today, here tomorrow? Good WV, Gendron RL. Clin Exp Ophthalmol. 2005 Aug;33(4):339-40. doi: 10.1111/j.1442-9071.2005.01057.x. PMID: 16033340 No abstract available. |
Retinopathy of prematurity's turning point. Good WV, Gendron RL. Br J Ophthalmol. 2005 Feb;89(2):127-8. doi: 10.1136/bjo.2004.058560. PMID: 15665336 Free PMC article. No abstract available. |
Conditional knockdown of tubedown-1 in endothelial cells leads to neovascular retinopathy. Wall DS, Gendron RL, Good WV, Miskiewicz E, Woodland M, Leblanc K, Paradis H. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3704-12. doi: 10.1167/iovs.03-1410. PMID: 15452080 |
Carlson EC, Mamiya K, Liu CY, Gendron RL, Birk DE, Funderburgh JL, Kao WW. Biochem J. 2003 Feb 1;369(Pt 3):461-8. doi: 10.1042/BJ20020593. PMID: 12381269 Free PMC article. |
Paradis H, Liu CY, Saika S, Azhar M, Doetschman T, Good WV, Nayak R, Laver N, Kao CW, Kao WW, Gendron RL. Dev Biol. 2002 Sep 1;249(1):140-55. doi: 10.1006/dbio.2002.0757. PMID: 12217325 |
TGFbeta2 in corneal morphogenesis during mouse embryonic development. Saika S, Saika S, Liu CY, Azhar M, Sanford LP, Doetschman T, Gendron RL, Kao CW, Kao WW. Dev Biol. 2001 Dec 15;240(2):419-32. doi: 10.1006/dbio.2001.0480. PMID: 11784073 |
Good WV, Gendron RL. Ophthalmol Clin North Am. 2001 Sep;14(3):513-9. doi: 10.1016/s0896-1549(05)70249-2. PMID: 11705151 Review. |
Gendron RL, Good WV, Adams LC, Paradis H. Invest Ophthalmol Vis Sci. 2001 Nov;42(12):3000-7. PMID: 11687548 |
Gene therapy for retinopathy of prematurity: the eye is a window to the future. Good WV, Gendron RL. Br J Ophthalmol. 2001 Aug;85(8):891-2. doi: 10.1136/bjo.85.8.891. PMID: 11466236 Free PMC article. No abstract available. |
MK/T-1, an immortalized fibroblast cell line derived using cultures of mouse corneal stroma. Gendron RL, Liu CY, Paradis H, Adams LC, Kao WW. Mol Vis. 2001 May 8;7:107-13. PMID: 11344338 |
Paradis H, Gendron RL. J Cell Sci. 2000 Dec;113 Pt 23:4331-9. doi: 10.1242/jcs.113.23.4331. PMID: 11069777 |
Tubedown-1, a novel acetyltransferase associated with blood vessel development. Gendron RL, Adams LC, Paradis H. Dev Dyn. 2000 Jun;218(2):300-15. doi: 10.1002/(SICI)1097-0177(200006)218:2<300::AID-DVDY5>3.0.CO;2-K. PMID: 10842358 |
Embryonic vasculogenesis by endothelial precursor cells derived from lung mesenchyme. Akeson AL, Wetzel B, Thompson FY, Brooks SK, Paradis H, Gendron RL, Greenberg JM. Dev Dyn. 2000 Jan;217(1):11-23. doi: 10.1002/(SICI)1097-0177(200001)217:1<11::AID-DVDY2>3.0.CO;2-L. PMID: 10679926 |
Gendron RL. Surv Ophthalmol. 1999 Sep-Oct;44(2):184-5. PMID: 10541158 Review. No abstract available. |
Differentiation responses of embryonic endothelium to leukemia inhibitory factor. Paradis H, Arceci RJ, Adams LC, Gendron RL. Exp Cell Res. 1998 Apr 10;240(1):7-15. doi: 10.1006/excr.1998.4006. PMID: 9570916 |
Gendron RL, Paradis H, Hsieh-Li HM, Lee DW, Potter SS, Markoff E. Biol Reprod. 1997 May;56(5):1097-105. doi: 10.1095/biolreprod56.5.1097. PMID: 9160706 |
Induction of embryonic vasculogenesis by bFGF and LIF in vitro and in vivo. Gendron RL, Tsai FY, Paradis H, Arceci RJ. Dev Biol. 1996 Jul 10;177(1):332-46. doi: 10.1006/dbio.1996.0167. PMID: 8660899 |
P-glycoprotein is expressed in the mineralizing regions of the skeleton. Mangham DC, Cannon A, Komiya S, Gendron RL, Dunussi K, Gebhardt MC, Mankin HJ, Arceci RJ. Calcif Tissue Int. 1996 Mar;58(3):186-91. doi: 10.1007/BF02526885. PMID: 8852574 |
Baines MG, Duclos AJ, de Fougerolles AR, Gendron RL. Am J Reprod Immunol. 1996 Jan;35(1):34-42. doi: 10.1111/j.1600-0897.1996.tb00006.x. PMID: 8789558 |
Baines MG, Billingsley KA, De Fougerolles AR, Duclos AJ, Olney HJ, Pomerantz DK, Gendron RL. J Reprod Immunol. 1994 Jan;26(1):17-30. doi: 10.1016/0165-0378(93)00863-o. PMID: 8040834 Free PMC article. |
Gendron RL, Farookhi R, Baines MG. Biol Reprod. 1992 Jul;47(1):72-5. doi: 10.1095/biolreprod47.1.72. PMID: 1322197 |
Expression of tumor necrosis factor alpha in the developing nervous system. Gendron RL, Nestel FP, Lapp WS, Baines MG. Int J Neurosci. 1991 Sep;60(1-2):129-36. doi: 10.3109/00207459109082043. PMID: 1774144 |
Gendron RL, Nestel FP, Lapp WS, Baines MG. J Reprod Fertil. 1990 Nov;90(2):395-402. doi: 10.1530/jrf.0.0900395. PMID: 2250238 |
Gendron RL, Farookhi R, Baines MG. J Reprod Fertil. 1990 May;89(1):277-84. doi: 10.1530/jrf.0.0890277. PMID: 2374121 |
Are both endogenous and exogenous factors involved in spontaneous foetal abortion? Baines MG, Gendron RL. Res Immunol. 1990 Feb;141(2):154-8. doi: 10.1016/0923-2494(90)90135-l. PMID: 2202028 Review. No abstract available. |
Morphometric analysis of the histology of spontaneous fetal resorption in a murine pregnancy. Gendron RL, Baines MG. Placenta. 1989 May-Jun;10(3):309-18. doi: 10.1016/0143-4004(89)90031-3. PMID: 2771899 |
Infiltrating decidual natural killer cells are associated with spontaneous abortion in mice. Gendron RL, Baines MG. Cell Immunol. 1988 May;113(2):261-7. doi: 10.1016/0008-8749(88)90025-1. PMID: 3282676 |