Thesis Proposal Presentation: A novel and interactive heatmap tool and its application to an intersp

Kunal Dhir
M.Sc. Thesis Proposal
Co-Supervisors: Drs. Lourdes Pena-Castillo and Edward Brown

“A novel and interactive heatmap tool and its application to an interspecies protein abundance data”

Department of Computer Science
Friday, April 22, 2016, 1:00 p.m., Room EN 2022


Heatmaps are a type of visualization tool, often used in bioinformatics data visualization for identifying patterns and hidden associations across biological samples. The majority of heatmap tools available today are static, and do not explore functional annotation that such data can provide. Here, we propose an interactive heatmap tool that will allow the user to zoom, visualize functional annotations, and explore changes in clustering. To demonstrate the benefits, we will use this tool to visualize protein abundance among the orthologs in three bacterial species under two experimental conditions. These species are namely Rhodobacter capsulatus, Rhodobacter sphearoides and Rhodopseudomonas palusturis. Analyzing what protein expression is being conserved in these bacteria species and how they respond to presence or absence of phosphorous will help in understanding whether these proteins functionally diverged during evolution. Such analysis is enhanced by the new exploratory tool.


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