Seminar: GWAS data analysis of colorectal cancer using PLINK

Zobeda Dewan
M.Sc. Candidate
Supervisor: Dr. Ting Hu

GWAS data analysis of colorectal cancer using PLINK

Department of Computer Science
Thursday, August 11, 2016, 2:30 p.m., Room EN 2022


The main goal of human genetic testing also known as DNA testing is to find out genetic risk factors for common and complex diseases (e.g., type 2 diabetes, heart diseases) and for Mendelian disease such as sickle cell anemia. In order to identify genetic risk factors for diseases those are common in population, Genome Wide Association Study (GWAS) technology is being used. This technology facilitates the analysis and measurement of DNA sequence variations from across the human genome. Different kinds ofsoftware tools have been used for analysis of increasingly large genome-related data sets. Some of those are EIGANSTRAT, SNAP, PLINK, and so on. Among all of these tools, PLINK is designed to perform a wide range of basic and large scale analysis in computationally efficient manner. In this project I explored how to leverage the power of PLINK for GWAS data analysis of colorectal cancer data set. There is a GUI interface for PLINK called gPLINK, which has used to construct PLINK operations with haploview epresentation.