Nathan Agnew
- M.Sc. Candidate (Biochemistry)
- Research: My project involves Molecular Dynamics Simulation (MD Sims) of Natural and Acute Respiratory Distress Syndrome (ARDS) damaged lung surfactant proteins; specifically unmodified and oxidized truncated isoforms of SP-B (Surfactant Protein B) or Mini-B in complex with lipid monolayers composed of 7:3 ratio of DPPC:POPG. MD Sims will provide insight into structural changes induced by modification including
1) degree of similarity between structures found in curved micelles vs. planar lipid systems;
2) preferred peptide depth within monolayers and/or bilayers; and
3) preferred peptide orientationwith monolayers and/or bilayers.
MD Sims will be repeated using oxidative modifications to assess the impact of the modifications on peptide orientation and/or depth and provide high quality predictions that can be directly compared to results gained from solid state NMR. - Academic Background:
B.Sc. (Biochemistry, Physical Chemistry double major) University of Houston, Texas