Education:

• 1990 Post-doctoral Fellow, Dept. Biochemistry, University of Alberta.
• 1984 Ph.D. University of Birmingham, UK.

Academic Appointments:

1990 Assistant Professor, Dept. Biochemistry, Memorial University.                    2021 Honorary Research Professor, Dept. Biochemistry, Memorial University.

 

Publications (selected)

Silva and Heeley (2021). Existence in the actin world of a specialized slow skeletal muscle isoform. Comp. Biochem. Physiol (B) 254, 110568.

Silva, Goonasekara, Hayley and Heeley (2020). Further investigation into the biochemical effects of phosphorylation of tropomyosin Tpm1.1. Serine-283 is in communication with the mid-region. Biochemistry 59, 4725 – 4734.

Silva, Ige, Goonasekara and Heeley (2020). Threonine-77 is a determinant of the low temperature conditioning of the most abundant isoform of tropomyosin in Atlantic salmon. Biochemistry 59, 2859 – 2869.

Heeley, White and Taylor (2019). Investigation into the mechanism of thin filament regulation by transient kinetics and equilibrium binding: Is there a conflict? J. Gen Physiol. 151, 628 – 634.

Risi, Eisner, Belknap, Heeley, White, Schröder and Galkin (2017).
Ca2+-induced Movement of Tropomyosin on Native Cardiac Thin Filaments Revealed by Cryo Electron Microscopy. Proc. Natl. Acad. Sci. 114, 6782 - 6787

Lohmeier-Vogel and Heeley (2016). Biochemical Comparison of Tpm1.1 (alpha) and Tpm2.2 (beta) Tropomyosins from Rabbit Skeletal Muscle.             Biochemistry 55, 1418 - 1427.

Fudge and Heeley (2015). Biochemical characterization of the roles of glycines-24 and 27 and threonine-179 in tropomyosin from the fast skeletal trunk muscle of Atlantic salmon. Biochemistry 54, 2769 – 2776.

(Houmeida / Heeley)*, Belknap and White (2010). Mechanism of regulation of native cardiac thin filaments by rigor cardiac myosin S1 & Ca(II).                             J. Biol. Chem. 285, 32760 – 32769.

Heeley, Belknap and White (2006). Maximal activation of thin filaments requires both rigor myosin S1 and calcium. J. Biol. Chem. 281, 668 – 676.

Heeley, Belknap and White (2002). Mechanism of regulation of Pi dissociation from actomyosin-ADP-Pi by thin filament. Proc. Natl. Acad. Sci. 99, 16731 –  36.

 

Seminars (selected)

100 years of enzymes as proteins - the James Sumner story (forthcoming)

Effect of myosin essential light chains (A1 and A2) on actomyosin kinetics (2019)

The tubulin code is a traffic controller (2016)

Phosphorylation of the muscle protein tropomyosin (2015)

Interview workshop - for undergraduates (2013)

Life in (and out) of Graduate School (2011)

Cyclotides - protein circles (2009)

Fred Sanger and the sequencing of insulin (2008)

D-amino acids on the rise (2005)

Discovery of an actin isoform specific to slow muscle (2004)

Amino acids: past, present and future (2003)