Publications

Coady BM, Marshall JD, Hattie LE, Brannan AM, Fitzpatrick MN, Hickey KE, Wallin S, Booth V, Brown RJ. (2018) Characterization of a peptide containing the major heparin binding domain of human hepatic lipase. J Pept Sci 24:e3123. (Link)

Christian SL, Pallegar NK, Brown RJ, Viloria-Petit AM. (2018) Collagen overlays can inhibit leptin and adiponectin secretion but not lipid accumulation in adipocytes. PeerJ 6:e4641. (Link)

Thyagarajan N, Marshall JD, Pickett AT, Schumacher C, Yang Y, Christian SL, Brown RJ. (2017) Transcriptomic analysis of THP-1 macrophages exposed to lipoprotein hydrolysis products generated by lipoprotein lipase. Lipids 52:189-205. (Link)

Thyagarajan N, Brannan AM, Brown RJ. (2016) Can we make high-density lipoproteins great again? Circulation 133:1833-5. (Link)

Fairbridge NA, Southall TM, Ayre DC, Komatsu Y, Raquet PI, Brown RJ, Randell E, Kovacs CS, Christian SL. (2015) Loss of CD24 in mice leads to metabolic dysfunctions and a reduction in white adipocyte tissue. PLoS One 10:e0141966. (Link)

Yang Y, Thyagarajan N, Coady BM, Brown RJ. (2014) Cholesterol efflux from THP-1 macrophages is impaired by the fatty acid component from lipoprotein hydrolysis by lipoprotein lipase. Biochem. Biophys. Res. Commun. 451:632-6. (Link)

Yang Y, Kuwano T, Lagor WR, Albert CJ, Brenton S, Rader DJ, Ford DA, Brown RJ. (2014) Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species. Lipids 49:505-15. (Link)

Demian WLL, Jahouh F, Stansbury D, Randell E, Brown RJ, Banoub JH. (2014) Characterizing changes in snow crab (Chionoecetes opilio) cryptocyanin protein during molting by MALDI-MS and MALDI-MS/MS. Rapid Commun. Mass Spectrom. 28:355-69.(Link)

Balogun KA, Albert CJ, Ford DA, Brown RJ, Cheema SK. (2013) Dietary omega-3 polyunsaturated fatty acids alter the fatty acid composition of hepatic and plasma bioactive lipids in C57BL/6 mice: a lipidomic approach. PLoS One 8:e82399.(Link)

Essaji Y, Yang Y, Albert CJ, Ford DA, Brown RJ. (2013) Hydrolysis products generated by lipoprotein lipase and endothelial lipase differentially impact THP-1 macrophage cell signalling pathways. Lipids 48:769-78.*(Link)

Brown RJ, Shao F, Baldán A, Albert CJ, Ford DA. (2013) Cholesterol efflux analyses using stable isotopes and mass spectrometry. Anal. Biochem. 433:56-64.(Link)

Bowden JA, Shao F, Albert CJ, Lally JW, Brown RJ, Procknow JD, Stephenson AH, Ford DA. (2011) Electrospray ionization tandem mass spectrometry of sodiated adducts of cholesteryl esters. Lipids 46:1169-79.(Link)

Brown RJ, Lagor WR, Sankaranaravanan S, Yasuda T, Quertermous T, Rothblat GH, Rader DJ. (2010) Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins. Circ. Res. 107:357-64.(Link)

Brown RJ, Edmondson AC, Griffon N, Hill TB, Fuki IV, Badellino KO, Li M, Wolfe ML, Reilly MP, Rader DJ. (2009) A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis. J. Lipid Res. 50:1910-6.(Link)

Edmondson AC, Brown RJ, Kathiresan S, Cupples LA, Demissie S, Manning AK, Jensen MK, Rimm EB, Wang J, Rodrigues A, Bamba V, Khetarpal SA, Wolfe ML, Derohannessian S, Li M, Reilly MP, Aberle J, Evans D, Hegele RA, Rader DJ. (2009) Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. J. Clin. Invest. 119:1042-50.(Link)

Lagor WR, Brown RJ, Toh SA, Millar JS, Fuki IV, de la Llera-Moya M, Yuen T, Rothblat G, Billheimer JT, Rader DJ. (2009) Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo. Arterioscler. Thromb. Vasc. Biol. 29:40-6.(Link)

Brown RJ, Rader DJ. (2008) When HDL gets fat.. Circ. Res. 103:131-2.(Link).

Brown RJ, Rader DJ. (2007) Lipases as modulators of atherosclerosis in murine models. Curr. Drug Targets 8:1307-19.(Link)

Brown RJ, Miller GC, Griffon N, Long CJ, Rader DJ. (2007) Glycosylation of endothelial lipase at asparagine-116 reduces activity and the hydrolysis of native lipoproteins in vitro and in vivo. J. Lipid Res. 48:1132-9.(Link)

Sun F, Avramoglu RK, Vassiliou G, Brown RJ, Ko KW, McPherson R, Yao Z. (2005) Do clustered beta-propeller domains within the N-terminus of LRP1 play a functional role? Biochim. Biophys. Acta 1721:139-51.(Link)

Brown RJ, Gauthier A, Parks RJ, McPherson R, Sparks DL, Schultz JR, Yao Z. (2004) Severe hypoalphalipoproteinemia in mice expressing human hepatic lipase deficient in binding to heparan sulfate proteoglycan. J. Biol. Chem. 279:42403-9.(Link)

Brown RJ, Schultz JR, Ko KW, Hill JS, Ramsamy TA, White AL, Sparks DL, Yao Z. (2003) The amino acid sequences of the carboxyl termini of human and mouse hepatic lipase influence cell surface association. J. Lipid Res. 44:1306-14.(Link)

Ramsamy TA, Boucher J, Brown RJ, Yao Z, Sparks DL. (2003) HDL regulates the displacement of hepatic lipase from cell surface proteoglycans and the hydrolysis of VLDL triacylglycerol. J. Lipid Res. 44:733-41.(Link)

Pulido-Cejudo G, Conway B, Proulx P, Brown RJ, Izaguirre CA. (1997) Bestatin-mediated inhibition of leucine aminopeptidase may hinder HIV infection. Antiviral Res. 36:167-77.(Link)

Contact

Robert Brown

230 Elizabeth Ave, St. John's, NL, CANADA, A1B 3X9

Postal Address: P.O. Box 4200, St. John's, NL, CANADA, A1C 5S7

Tel: (709) 864-8000