Biology 4250 - Evolutionary Genetics

Steven M. Carr
Dr. Steven M. Carr

Department of Biology
Memorial University of Newfoundland
    
(
University Diary)
St. John's NL A1B 3X9, Canada
  e-mail: scarr@mun.ca



    Bio4250 Course Outline updated 07 August 2022

   
Optional Text: G-P Sætre & M Ravient (2019) Evolutionary Genetics: Concepts, Analysis, and Practice [ S&R 2019 ]
      
     MATLAB software

    
MEGA X (Molecular Evolutionary Genetics Analysis) software

Other web pages of interest:

      Genetic Research in Carr lab
      Bio2250 - Principles of Genetics for Bio4250
      Bio2900 - Principles of Systematics & Evolution    

      Bio4241 - Advanced Genetics 
      Bio4270 - History of Biology                                      


Click here to e-mail me questions, comments, or suggestions.
    Please include '4250' in the subject line


Lectures:         Tu Th             0900 - 1015    Sn-1019 TBA
Labs:                Th                  1400 - 1700    C-2026 TBA
    
Office Hours:  Tu Th             1030 - 1130    CSF-4342

            On the importance of office hours (NPR, Oct 2019)

Course lecture notes:

.
Week
Lectures
S & R (2019)
Topic
Last
Revised
Lab
Date
Lab Materials
1
06 Sept

Introduction
08 Aug 2022
08 Sept 2022
Statistical Hypothesis Testing; DNA structure;
Install MATLAB; Install MEGA
1 & 2
08, 13, 15 Sept

Allele & Genotype frequencies; Hardy-Weinberg Theorem 08 Aug 2022 15 Sept 2022  Chi-square; Critical values; Workbook for Chi-Square (2021 Sept 16);
Lab Exercises: Testing Hardy-Weinberg expectations
3
20, 22 Sept

Darwin's Theory of Natural Selection
08 Aug 2022 22 Sept 2022 Workbook for Natural selection exercises (2021 Sept 23)
4
27 & 29 Sept
4.2; 5.2
The General Theory of Natural Selection
08 Aug 2022 29 Sept 2022 Lab Exercise: Natural Selection in ecological genetics (2020 Oct 08);
Estimation of Selection Coefficients (2021 Oct 07)


30 Sept

National Day of Truth & Reconciliation

30 Sept
5 04, 06 Oct
Additional topics in Natural Selection 08 Aug 2022 06 Oct 2022
Lab exercise: Selection in variable environments (2021 Oct 07);
Excel worksheet for variable environment exercise
6
10-12 Oct

Fall Break


No Lecture, Oct 11
6
13 Oct

Midterm Exam (Sample)

13 Oct 2022
Midterm in Lab slot
7
18, 20 Oct
1.3; 2 Fitness, Adaptation, & Selection in Natural Populations
08 Aug 2022 20 Oct 2022 Lab exercise: Selection vs Mutation & Migration
Excel worksheet
for u & m
8
25, 27 Oct, 01 Nov
1.2; 2
Mutation;
Migration;
Inbreeding
08 Aug 2022 27 Oct 2022 Lab Exercise: Migration / Selection in Water Snakes;
Excel worksheet for m & s (2021 Oct 28)

9 & 10
03, 08 Nov
2.2; 3.4; 4.4
Mendel's Century (1901 - 2021) 08 Aug 2022 03 Nov 2022 Data sets for allozyme, DNA, Micro-satellite analysis (TBA)
10 11 Nov
Remembrance Day
10 Nov 2022
No Lecture or Lab
11
15, 17 Nov
2; 3.3,4,5
Genetic Drift;
Selection & Genetic Drift in Finite Populations;
08 Aug 2022 17 Nov 2022 WriFish program ; MATLAB program (2020 Oct 29);
Lab Exercise: Natural Selection & Genetic Drift (2021 Nov 05)
12 22, 24 Nov 3.2,3 Molecular Phylogeography:
Genetic variation in time & space
08 Aug 2022 24 Nov 2022 Lab Exercise: F-statistics & Population Structure (2021 Nov 18);
Excel worksheet for F-statistics (2021 Nov 15)
13
29 Nov, 01 Dec
8
Molecular Systematics: Phylogenetic reconstruction [Review] 08 Aug 2022 01 Dec 2022 (?)
Download MEGA:
Lab Exercise: Molecular Evolutionary Genetics Analysis (2021 Nov 25)
Final


FINAL EXAM: Thurs, 08 Dec, 0900-1200
Sample questions

Thurs, 08 Dec
0900 - 1200
Expected time from previous years


N&S (2013)
Additional Material from Nielsen & Slatkin (2013)





3, 4
Coalescent Theory; Selective Neutrality




5
Population History & Demography




ACKNOWLEDGMENTS - sources for images

Site last modified 07 August 2022
This page was first published on 20 August 2017

Copyright statement:
The lectures, displays, and all material delivered or provided in Biol4250 - Evolutionary Genetics © Steven M Carr, including any visual or audio recording thereof, are subject to copyright owned by Steven M Carr.
It is prohibited
to record, copy, or share by any means, in any format, openly or surreptitiously, in whole or in part, in the absence of express written permission from Steven M Carr, any of the lectures, displays, or materials provided or published in any form during or from this course.


Dedicated to my daughters Jennifer Megan, Matilda Kathleen & Eowyn Suzanne,
                       my wife Justyna ,
                       to Norman Borlaug (1914 - 2009), Geneticist, Nobel Peace Laureate 1970,
& Friend of the People of the Earth
                       & to Dave Wake (1936 - 2021), Evolutionary Biologist & teacher extraordinaire


 All text material © 2022 by Steven M Carr