Biology 4250 - Evolutionary Genetics

Steven M. Carr
Dr. Steven M. Carr

Department of Biology
Memorial University of Newfoundland
    
(
University Diary)
St. John's NL A1B 3X9, Canada
  e-mail: scarr@mun.ca



    Bio4250 Course Outline updated 13 August 2022

   
Optional Text: G-P Sætre & M Ravient (2019) Evolutionary Genetics: Concepts, Analysis, and Practice [ S&R 2019 ]
      
     MATLAB software

    
MEGA X (Molecular Evolutionary Genetics Analysis) software

Other web pages of interest:

      Genetic Research in Carr lab
      Bio2250 - Principles of Genetics for Bio4250
      Bio2900 - Principles of Systematics & Evolution    

      Bio4241 - Advanced Genetics 
      Bio4270 - History of Biology                                      


Click here to e-mail me questions, comments, or suggestions.
    Please include '4250' in the subject line


Lectures:         Tu Th             0900 - 1015    Sn-1019 TBA
Labs:                Th                  1400 - 1700    C-2026 TBA
    
Office Hours:  Tu Th             1030 - 1130    CSF-4342

            On the importance of office hours (NPR, Oct 2019)

Course lecture notes:

.
Week
Lectures
S & R (2019)
Topic
Last
Revised
Lab
Date
Lab Materials
1
06 Sept

Introduction
08 Aug 2022
08 Sept 2022
Lab Exercise: DNA structure;
Install MATLAB; Install MEGA
1 & 2
08, 13, 15 Sept

Allele & Genotype frequencies; Hardy-Weinberg Theorem 08 Aug 2022 15 Sept 2022 Statistical Hypothesis Testing; Chi-square test; Workbook for Chi-Square test (2022 Sept 13);
Lab Exercises: Testing Hardy-Weinberg expectations
3
20, 22 Sept

Darwin's Theory of Natural Selection
08 Aug 2022 22 Sept 2022 Workbook for Natural selection exercises (2021 Sept 23)
4
27 & 29 Sept
4.2; 5.2
The General Theory of Natural Selection
08 Aug 2022 29 Sept 2022 Lab Exercise: Natural Selection in ecological genetics (2020 Oct 08);
Estimation of Selection Coefficients (2021 Oct 07)


30 Sept

National Day of Truth & Reconciliation

30 Sept
5 04, 06 Oct
Additional topics in Natural Selection 08 Aug 2022 06 Oct 2022
Lab exercise: Selection in variable environments (2021 Oct 07);
Excel worksheet for variable environment exercise
6
10-12 Oct

Fall Break


No Lecture, Oct 11
6
13 Oct

Midterm Exam (Sample)

13 Oct 2022
Midterm in Lab slot
7
18, 20 Oct
1.3; 2 Fitness, Adaptation, & Selection in Natural Populations
08 Aug 2022 20 Oct 2022 Lab exercise: Selection vs Mutation & Migration
Excel worksheet
for u & m
8 & 9
25, 27 Oct, 01 Nov
1.2; 2
Mutation;
Migration;
Inbreeding
08 Aug 2022 27 Oct 2022 Lab Exercise: Migration / Selection in Water Snakes;
Excel worksheet for m & s (2021 Oct 28)

9 & 10
03, 08 Nov
2.2; 3.4; 4.4
Mendel's Century (1901 - 2021) 08 Aug 2022 03 Nov 2022 Data sets for allozyme, DNA, Micro-satellite analysis (TBA)
10 11 Nov
Remembrance Day
10 Nov 2022
No Lecture or Lab
11
15, 17 Nov
2; 3.3,4,5
Genetic Drift;
Selection & Genetic Drift in Finite Populations;
08 Aug 2022 17 Nov 2022 WriFish program ; MATLAB program (2020 Oct 29);
Lab Exercise: Natural Selection & Genetic Drift (2021 Nov 05)
12 22, 24 Nov 3.2,3 Molecular Phylogeography:
Genetic variation in time & space
08 Aug 2022 24 Nov 2022 Lab Exercise: F-statistics & Population Structure (2021 Nov 18);
Excel worksheet for F-statistics (2021 Nov 15)
13
29 Nov, 01 Dec
8
Molecular Systematics: Phylogenetic reconstruction [Review] 08 Aug 2022 01 Dec 2022 (?)
Download MEGA:
Lab Exercise: Molecular Evolutionary Genetics Analysis (2021 Nov 25)
Final


FINAL EXAM: Thurs, 08 Dec, 0900-1200
Sample questions

Thurs, 08 Dec
0900 - 1200
Expected time from previous years


N&S (2013)
Additional Material from Nielsen & Slatkin (2013)





3, 4
Coalescent Theory; Selective Neutrality




5
Population History & Demography




ACKNOWLEDGMENTS - sources for images

 I acknowledge that the lands on which this work is presented are situated are in the traditional territories of diverse Indigenous groups, and I acknowledge with respect the diverse histories and cultures of the Beothuk, Mi'kmaq, Innu, and Inuit of this province.

Site last modified 13 September 2022
This page was first published on 20 August 2017

Copyright statement:
The lectures, displays, and all material delivered or provided in Biol4250 - Evolutionary Genetics © Steven M Carr, including any visual or audio recording thereof, are subject to copyright owned by Steven M Carr.
It is prohibited
to record, copy, or share by any means, in any format, openly or surreptitiously, in whole or in part, in the absence of express written permission from Steven M Carr, any of the lectures, displays, or materials provided or published in any form during or from this course.


Dedicated to my daughters Jennifer Megan, Matilda Kathleen & Eowyn Suzanne,
                       my wife Justyna ,
                       to Norman Borlaug (1914 - 2009), Geneticist, Nobel Peace Laureate 1970,
& Friend of the People of the Earth
                       & to Dave Wake (1936 - 2021), Evolutionary Biologist & teacher extraordinaire


 All text material © 2022 by Steven M Carr