|Phone: (709) 864-2323|
|Affiliations: Behavioural Neuroscience|
My research interests are focused largely on the function of the primary norepinephrine containing nucleus, the locus coeruleus (LC), located in mammalian brainstem. Although this nucleus is small, it has the capacity to modulate brain plasticity, memory, and complex cognitive processes. Recent evidence also strongly suggests that the pathological changes underlying Alzheimer’s disease are first initiated by abnormal LC function, which may develop as early as young adulthood. Our work examines LC modulation of temporal lobe (entorhinal cortex and hippocampus) function, and additionally we are working with a small team of MUN researchers to develop a novel LC-dependent rodent model of Alzheimer’s disease. Examples of research techniques used in the lab include electrophysiology, immunohistochemistry, viral vector technology, optogenetics, and electrochemistry.