Office of the Registrar
Faculty of Science (2007/2008)
5 Program Regulations and Course Descriptions
5.1 Biochemistry
5.1.1 Programs

The following undergraduate programs are available in the Department:

  1. Major or Honours in Biochemistry

  2. Major or Honours in Nutrition

  3. Major or Honours in Dietetics - Admission to this program is under review. For further information see Important Note under Professional Program in Dietetics.

  4. Joint Honours in Biochemistry and Cell Biology/Microbiology

  5. Joint Honours in Biochemistry and Chemistry

  6. Joint Honours in Biochemistry and Physics

  7. Joint Honours in Biochemistry (Nutrition)/Psychology (Behavioural Neuroscience)

  8. Joint Honours in Biochemistry/Psychology (Behavioural Neuroscience)

  9. Minor in Biochemistry

  10. Minor in Nutrition

Students who wish to enrol in any of these programs should plan their program well in advance so that they will have taken the appropriate prerequisites. Entry to a number of required courses is limited and will be determined by academic performance. Required courses should be taken in the year indicated by the course numbers so as to avoid timetable clashes and missing prerequisites which could prolong the time necessary to complete the program. Students are advised to consult with the Department at the earliest opportunity.

Candidates for the general and honours degrees in the programs above should refer to the UNIVERSITY REGULATIONS - General Academic Regulations (Undergraduate) for the General and Honours degrees of Bachelor of Science.

Students who intend to pursue graduate studies should take the courses leading to the honours degree.

Note:

Supplementary examinations will be allowed in certain Biochemistry courses which have written final examinations. Students should refer to the Faculty of Science Degree Regulations for details.

5.1.2 Admission to Programs

Students who wish to declare a Major in Biochemistry or Biochemistry (Nutrition) or who wish to apply for Honours standing in any of our programs are strongly recommended to do so by June 30 in any year. Students who do not declare by this date may not be considered for departmental scholarship or other awards.

5.1.3 Biochemistry Program
5.1.3.1 Major in Biochemistry

Entry to the Biochemistry Majors program is based on academic standing.

  1. To be considered for admission to the program students must have at least 30 credit hours in courses and have successfully completed the following courses (or their equivalents) with a minimum overall average of 60%. In addition, students must be eligible for entry to Chemistry 2400.

    1. English 1080, 1110 (or equivalent)

    2. Chemistry 1050, 1051 (or Chemistry 1010, 1011 or 1201, 1001)

    3. Mathematics 1000, 1001 (or Math 1090, 1000)

    4. Physics 1050, 1051 (or Physics 1020, 1021), or Biology 1001, 1002

  2. Required courses to complete the major:

    1. Biochemistry 2100, 2101, 3105, 3106, 3107, 3108.

    2. At least 12 credit hours in courses from Biochemistry 3200, 4002, 4101, 4103, 4104, 4200, 4201.

    3. Medicine 310A, 310B or 6 credit hours from Biology 2060, 3050, 3401, 3402, 3530, 4200, 4245, 4404, Chemistry 4201

    4. Biology 1001 and 1002; Mathematics 1001; and Physics 1020 or 1050, and 1051 for those students who did not complete them in first year. Students may also need to complete Physics 1021 in order to fulfil this requirement.

    5. Chemistry 1031 which is strongly advised to be taken prior to second year for those students who complete Chemistry 1010 and 1011 in first year. see Note 2. below.

    6. Chemistry 2300, 2400, 2401

    7. one of Chemistry 3100, Environmental Sciences 3210, Environmental Sciences 3211.

    Notes:

    1. Students are required to complete at least 78 credit hours in Science courses for the General Degree.

    2. Majors who take Chemistry 1010/1011 but not Chemistry 1031 as part of their first year sequence risk waiting a whole year before they can continue taking Biochemistry program courses.

    3. For the purposes of a Biochemistry degree, Medicine 310A and 310B count as Biochemistry courses.

  3. Students are encouraged to choose a minor.

5.1.3.2 Honours Degree in Biochemistry

Students normally should apply for an Honours program at the completion of their third year of studies. Honours students would normally follow the Biochemistry Majors program before applying to honours, and must meet its admissions requirements as follows:

  1. To be considered for admission to the majors program prior to admission to honours, students must have at least 30 credit hours in courses and have successfully completed the following courses (or their equivalents) with a minimum overall average of 60%. In addition, students must be eligible for entry to Chemistry 2400.

    1. English 1080, 1110 (or equivalent)

    2. Chemistry 1050, 1051 (or Chemistry 1010, 1011, or 1201, 1001)

    3. Mathematics 1000, 1001 (or Mathematics 1090, 1000)

    4. Physics 1050, 1051 (or Physics 1020, 1021) or Biology 1001, 1002

  2. To be eligible for admission, students must be in Honours standing. To be considered for early admission to an Honours program in Biochemistry at the end of second year, students must have achieved at least 70% in each of Biochemistry 2100 and 2101 and Chemistry 2400, 2401.

  3. Required courses:

    1. Biochemistry 2100, 2101, 3105, 3106, 3107, 3108, 4102, 499A, 499B, Medicine 310A, 310B.

    2. Biochemistry 4210 or 4211.

    3. Twelve credit hours in courses from Biochemistry 4002, 4101, 4103, 4104, 4200, 4201.

    4. At least 6 credit hours in courses from Biochemistry 3200, 3201, 4105, 4220, Biology 2060, 3050, 3530, 4200, 4245, 4404, Chemistry 4201.

    5. Biology 1001 and 1002; Mathematics 1001; and Physics 1020 or 1050, and 1051 for those students who did not complete them in first year. Students may also need to complete Physics 1021 in order to fulfil this requirement.

    6. Chemistry 1031 which is strongly advised to be taken prior to second year for those students who complete Chemistry 1010 and 1011 in first year (see Notes below).

    7. Chemistry 2300, 2400, 2401, one of 3410 or 3411.

    8. One of Chemistry 3100, Chemistry 3500, Environmental Sciences 3210, Environmental Sciences 3211.

    9. Statistics 2550 or equivalent.

      Notes:

      1. Majors who take Chemistry 1010/1011 but not Chemistry 1031 as part of their first year sequence risk waiting a whole year before they can continue taking Biochemistry program courses.

      2. For the purposes of a Honours Degree in Biochemistry, Medicine 310A and 310B count as Biochemistry courses.

  4. Students are encouraged to choose a minor.

    Those courses in which a grade "B" or an average of 75% or higher are required, as specified in clause 6. a. of the Regulations for the Honours Degree of Bachelor of Science, are 45 credit hours in Biochemistry courses and 15 credit hours in other courses (beyond the 1000-level) chosen from Biochemistry, Biology, or Chemistry. Biochemistry 2010, 2011, Biology 2040, 2041 and Chemistry 2600, 2601 may not be used to meet this requirement. Medicine 310A/B counts as Biochemistry for these 60 credit hours.

5.1.3.3 Minor in Biochemistry

Students who take a minor in Biochemistry will complete:

  1. Biochemistry 2101, 3106

  2. Either Biochemistry 2100 or Biology 2250

  3. nine credit hours from Biochemistry 3105, 3107, 3108, 4002, 4101, 4103, 4104, 4200, 4201; or 6 credit hours from these Biochemistry courses and 3 credit hours from Chemistry 4201, Biology 2060, 3050.

  4. Either Chemistry 2400, 2401 or Chemistry 2440 and 3 additional credit hours from the Biochemistry courses listed in 3. above.

Course prerequisites stipulated in the course descriptions shall apply to a minor in Biochemistry.

5.1.4 Nutrition Program
5.1.4.1 Major in Nutrition

Entry to the Nutrition majors program is based on academic standing.

  1. To be considered for admission to the program students must have at least 30 credit hours in courses and have successfully completed the following courses (or their equivalents) with a minimum overall average of 60%.

    1. English 1080, 1110 (or equivalent)

    2. Chemistry 1050, 1051 (or Chemistry 1010, 1011 or 1201, 1001)

    3. Mathematics 1090, 1000 (or Mathematics 1000 and one elective)

    4. Biology 1001, 1002 or Physics 1020, 1021 (or equivalent)

  2. Required courses to complete the major:

    1. Biochemistry 2000, 2100, 2101, 3106, 3200, 3201, 3202, 3402, 4300, 4301, Medicine 310A, 310B

    2. One of Biochemistry 3107, 3108, 4002

    3. Biology 1001 and 1002; and Physics 1020 and 1021 (or equivalent), for those students who did not complete them in first year

    4. Chemistry 2440 (or Chemistry 2400, 2401)

    5. Statistics 2550 or equivalent

  3. Students are encouraged to choose a minor.

Notes:

  1. Students are required to complete at least 78 credit hours in Science courses for the General Degree.

  2. Students who choose to complete Chemistry 2400/2401 are advised to take the appropriate prerequisites for those courses.

  3. For the purposes of a Biochemistry (Nutrition) degree, Medicine 310A and 310B count as Biochemistry courses.

5.1.4.2 Honours Degree in Nutrition

Students normally should apply for an Honours program at the completion of their third year of studies. Honours students would normally follow the Biochemistry (Nutrition) Majors program before applying to honours, and must meet its admissions requirements as follows:

  1. To be considered for admission to the majors program prior to admission to honours, students must have at least 30 credit hours in courses and have successfully completed the following courses (or their equivalents) with a minimum overall average of 60%:

    1. English 1080, 1110 (or equivalent)

    2. Chemistry 1050, 1051 (or Chemistry 1010, 1011, or 1201, 1001)

    3. Mathematics 1090, 1000 (or Mathematics 1000 and one elective)

    4. Biology 1001, 1002 or Physics 1020, 1021 (or equivalent)

  2. To be eligible for admission to the honours program, students must be in Honours standing. To be considered for early admission to an Honours program in Nutrition at the end of second year, students must have achieved at least 70% in each of their required 2000 level Biochemistry and Chemistry courses.

  3. Required courses:

    1. Biochemistry 2000, 2100, 2101, 3106, 3107, 3200, 3201, 3202, 3402, 4002, 4300, 4301, 4502, Medicine 310A, 310B.

    2. Nine additional credit hours chosen from Biochemistry 3105, 3108, 4101, 4103, 4104, 4105, 4200, 4201, 4210, 4211, 4220, 4400, Biology 3050.

    3. Either Biochemistry 499A/B or 4999 plus an additional 3 credit hours 4000 level Biochemistry course.

    4. Biology 1001 and 1002; and Physics 1020 and 1021 (or equivalent), for those students who did not complete them in first year.

    5. Chemistry 2440 (or Chemistry 2400, 2401).

    6. Statistics 2550 or equivalent.

  4. Students are encouraged to choose a minor.

  5. Those courses in which the grades specified in clause 6.a. of the Regulations for the Honours Degree of Bachelor of Science are 60 credit hours chosen from Biochemistry courses and Biology 3050.

    Notes:

    1. Students who choose to complete Chemistry 2400/2401 are advised to take the appropriate prerequisites for those courses.

    2. For the purposes of a Biochemistry (Nutrition) Honours degree, Medicine 310A and 310B count as Biochemistry courses.

5.1.4.3 Minor in Nutrition

Students who take a minor in Nutrition will complete:

  1. Biochemistry 2101, 3106, 3200, 3201, Medicine 310A, 310B.

  2. Six credit hours chosen from Biochemistry 3202, 4300, 4301.

Course prerequisites stipulated in the course descriptions shall apply to a minor in Nutrition. In particular, students should note that one of Chemistry 2440 or Chemistry 2401 are required as co-requisites or prerequisites to several courses.

5.1.5 Professional Program in Dietetics

For professional qualification as a dietitian, students are required to complete the degree in Dietetics, followed by an approved Dietetic Internship.

Note:

The Department of Biochemistry does not expect to admit students to the Dietetics program for Fall 2008. Further information on the status of the program can be obtained from the Department.

5.1.5.1 Admission to Dietetics

All applications for entry to the program for the Bachelor of Science in Dietetics must be submitted to the Head of the Department of Biochemistry by April 30 in any year.

Entrance to the program in Dietetics is on the basis of competition for a fixed number of places. The Admission Committee takes into account the applicant's academic background and information on an applicant's personal qualities and achievements as given by the applicant and by referees' reports.

  1. To be eligible for consideration, an applicant must have completed a minimum of 30 credit hours in courses which have been taken or accepted for credit at a recognized university or university college before entry to the Dietetics program.

  2. Students applying to enter are required to have successfully completed the following courses or their equivalents:

    1. Chemistry 1050, 1051 (or Chemistry 1010, 1011 or 1201, 1001)

    2. English 1080, 1110 (or equivalent)

    3. Mathematics 1090, 1000 (or Mathematics 1000 and one elective)

    4. Physics 1020 and 1021 (or Physics 1050 and 1051).

    5. either Biology 1001 and 1002 or Psychology 1000 and 1001

  3. No application will be considered from an applicant who cannot produce evidence that the above requirements have been met or will have been met by the time of entry into the Dietetics program.

  4. After admission, the program will consist of two years of study at this University and a final year at Acadia University. The number of seats available at Acadia University is limited. When a student is accepted into the Dietetics program at Memorial University of Newfoundland, the year that student is expected to attend Acadia University will be set. No guarantee of space will be available in other years.

5.1.5.2 Registration and Promotion

The following regulations apply to the program courses taken at Memorial University of Newfoundland.

  1. Biochemistry and Chemistry courses shall be taken in the program year indicated by the course number. Biology 1001 and 1002 must be completed by the end of the second year of the program. The remaining courses are to be scheduled so that the course load is five in each semester. Exceptions to this prescribed program, including specified course load, must have the approval of the Committee on Undergraduate Studies of the department. Students who have completed program courses in advance of admission to the program may arrange with the Committee a reduction in the required course load.

  2. For promotion from each term the requirements are: the achievement of a passing grade in all courses; an overall average of at least 60% in those courses required in each academic term; and completion of the appropriate course load as outlined above.

  3. Students who fail to achieve the standards outlined in the paragraph above will be required to withdraw from the program. They may be considered for readmission at which time they will normally be required to repeat the courses in which they failed, and/or to repeat courses which will raise the average to 60%, unless, in the opinion of the Head, a more meaningful course of study would be appropriate.

  4. In order to be considered for readmission, students must formally apply for readmission to the program not later than the deadline date specified in the first paragraph of the Admission section of this program.

5.1.5.3 Major in Dietetics
  1. Required courses at Memorial University of Newfoundland:

    1. Biochemistry 2000, 2010, 2011, 2100, 2101, 3106, 3200, 3201, 3202, Medicine 310A, 310B.

    2. Either Biochemistry 3054 or Biology 3050.

    3. Biology 1001, 1002 (if not taken in first year).

    4. Business 1000 and 2000.

    5. Chemistry 2440 (or Chemistry 2400, 2401)

    6. Statistics 2550 or equivalent.

    7. Six credit hours in social science courses if Psychology 1000 and 1001 were not taken in first year.

    8. Three credit hours in Computer Science.

    Notes:

    1. Students who choose to complete Chemistry 2400/2401 are advised to take the appropriate prerequisites for those courses.

    2. For the purposes of a Biochemistry (Dietetics) degree, Medicine 310A and 310B count as Biochemistry courses.

    The above courses must be completed before the year at Acadia University for both the General and the Honours Programs.

  2. Required courses at Acadia University:

    The equivalent of at least 18 senior level credit hours in nutrition and/or foods must be successfully completed at Acadia University. Courses to make up these credit hours are to be selected in consultation with faculty advisors at Memorial University of Newfoundland and Acadia University.

    Note:

    120 credit hours in courses must be obtained for the General Degree of Bachelor of Science (refer to Regulations for the General Degree of Bachelor of Science, Clause 1.

5.1.5.4 Honours Degree in Dietetics

Students normally should apply for an Honours program at the completion of their third year of studies. To be eligible for admission, students must be in Honours standing.

In addition to the courses required for the general degree, the program shall include: Either Biochemistry 499A/B or Biochemistry 4999 plus 3 additional credit hours in Nutrition at Memorial University of Newfoundland or Acadia University at the 4000 level.

The 60 credit hours in courses from clause 6. a. of the Regulations for the Honours degree of Bachelor of Science shall be chosen from the required Biochemistry courses in the program outlined above, the Nutrition and Foods courses at Acadia University, and Biology 3050.

5.1.6 Course List

In accordance with Senate's Policy Regarding Inactive Courses, the course descriptions for courses which have not been offered in the previous three academic years and which are not scheduled to be offered in the current academic year have been removed from the following listing. For information about any of these inactive courses, please contact the Head of the Department.

1430

Biochemistry for Nurses

is an introduction to the chemistry and structure-function relationships of carbohydrates, lipids and proteins. It will examine the basic metabolism of carbohydrates and fats, with emphasis on the biochemical fluctuations that occur in human health and disease, and will include a brief introduction to molecular genetics. This course may not be used for credit to fulfil the requirements for a major in the Department of Biochemistry. Entry into this course is restricted to students in the BN (Collaborative) Program. Prospective fast-track program students should consult with the School of Nursing concerning admission to this course.

Prerequisite: Level 3 Chemistry or Chemistry 1010 or Chemistry 1810 or equivalent.

Lectures: Four hours per week

Note:

Credit may be obtained for only one of Biochemistry 1430 and the former 2430.

2000

Principles of Food Science

enables one to gain an understanding of the scope of Food Science as a discipline. Topics include introductions to chemistry, processing, analysis, microbiology, packaging, product development, sensory evaluation and quality control as they are related to Food Science.

Prerequisite: Chemistry 2400 or 2440.

Lectures: Three hours per week.

Laboratory: One period per week.

2010

Introductory Foods I

is an introduction to the science of food and food preparation. Topics covered include fats and oils, simple and complex carbohydrates, fruits and vegetables, cereals and starches. Laboratory work applies scientific principles and theories to practical problems in food preparation.

Prerequisite: Chemistry 1011 or 1051.

Lectures: Three hours per week.

Laboratory: Three hours per week.

2011

Introductory Foods II

is an introduction to the science of food and food preparation. Topics covered include proteins - dairy products, eggs, meats and fish, legumes, gelatin and flour proteins, batters and doughs, meal management and menu planning. Laboratory work applies scientific principles and theories to practical problems of food preparation.

Prerequisite: Chemistry 1011 or 1051; Biochemistry 2010.

Lectures: Three hours per week.

Laboratory: Three hours per week.

2100

Introduction to Molecular Biology and Genetics

will cover the heritability of simple traits from phenotype to genotype; the discovery of DNA as the molecule of heredity; the structure and function of DNA; the elucidation of the genetic code; and the manipulation of DNA for recombinant DNA technology and biotechnology.

Prerequisites or co-requisites: Biochemistry 2101, Chemistry 2401, Physics 1021 or 1051. Students may replace the co-requisite Chemistry 2401 with Chemistry 2440 as a prerequisite. Chemistry 2440 may not be taken as a co-requisite of 2100.

Lectures: Three hours per week.

Laboratory: Three hours on alternate weeks.

2101

Introduction to Biochemistry

is an introduction to the major organic substances of living organisms, proteins, carbohydrates and lipids: their structure, analysis and biochemical function. Other topics will include: enzymes; the biochemistry of membranes, including the plasma membrane and specialized intracellular membranes; and the biochemistry of selected differentiated cells.

Prerequisites: Chemistry 2400, 2401, or Chemistry 2440; and Physics 1020 or 1050, and 1021 (or 1051). Chemistry 2401 and Physics 1021 or 1051 can be done concurrently.

Lectures: Three hours per week.

Laboratory: One three-hour laboratory period on alternate weeks to illustrate concepts covered in the lectures.

Note:

Credit may be obtained for only one of 2101, Pharmacy 2004, or the former Pharmacy 3110.

2600

Introduction to Human Nutrition

(same as HKR 2600) gives an overview of human nutrition with an emphasis on topics of current interest. Students will gain an understanding of nutrition in the context of health maintenance across the life span. Topics covered will include nutrition during pregnancy, nutrition for infants, Canadian Recommended Nutrient Intakes / Dietary Reference Intakes, weight loss and weight gain, nutriceuticals and ergogenic aids.

Notes:

  1. Credit can be received for only one of Biochemistry 2600, the former Kinesiology 2600, or HKR 2600.

  2. Students who have completed Biochemistry 3200 or 3201 may not subsequently receive credit for Biochemistry 2600.

  3. Students may not count Biochemistry 2600 among the 60 credit hours in Biochemistry courses required for Honours in Biochemistry, Honours in Nutrition, or Honours in Dietetics.

3052

Food Microbiology

- inactive course.

3054

Fundamentals of Food Microbiology

is an introduction to the basic principles of microbiology with an emphasis on the study of microorganisms that are found in foods. The role of microbes in food and food spoilage, and the role of food-borne pathogens in human illness and disease will each be discussed. Nutritional aspects of food-borne microorganisms will also be studied.

Lectures: Three hours per week.

Prerequisites: Biology 1002 and Biochemistry 2101.

Note:

Credit can only be received for only one of Biochemistry 3052, 3054, Biology 3052, and the former Biochemistry 3401.

3105

Physical Biochemistry

examines topics such as: types of intermolecular forces in biomolecules; the folding of biomolecules and the role of water; pH, buffers, and ionisation of biomolecules; thermodynamics: equilibria, coupled reactions, transport across membranes and redox reactions; and ligand binding. Other topics will include: size and shape of biomolecules; isotopes in biochemistry; and, spectroscopy of biomolecules.

Prerequisites: Biochemistry 2101; and Chemistry 2300 or Physics 2053.

Lectures: Three hours per week and a two hour problem-solving class.

3106

Metabolism

examines the catabolism of carbohydrates, lipids and amino acids. Other topics will be: mitochondria, chloroplasts and ATP synthesis; biosynthesis of carbohydrates and lipids; metabolic specialization of differentiated cells and tissues; and, integration of metabolism.

Prerequisite: Biochemistry 2101.

Lectures: Three hours per week.

Practical classes: One three-hour laboratory or one-hour tutorial per week.

Note:

Credit may be obtained for only one of Biochemistry 3106, the former Biochemistry 3102 or Pharmacy 3111.

3107

Nucleic Acid Biochemistry and Molecular Biology

examines the structure, function and biochemistry of DNA and RNA and the biochemical processes in the flow of information from the gene to protein. These will include: DNA replication, recombination and repair processes; transcription of RNA and RNA splicing; and protein synthesis. The regulation of gene expression will also be covered at an introductory level. The course will also include an introduction to cloning methodology.

Prerequisite: Biochemistry 2101; and Biochemistry 2100 or Biology 2250.

Lectures: Three hours per week.

Laboratory: Up to four hours per week which will normally consist of one three hour laboratory period plus one additional hour on the following day.

3108

Molecular Biochemistry of the Cell

focuses on the molecular biochemistry of intracellular regulation, including advances in topics such as signal transduction, apoptosis and cancer. Other topics will include protein processing and sorting, cyclins, G-protein structure, function and regulation, cell adhesion molecules and the structure of the extracellular matrix.

Lectures: Three hours per week.

Prerequisites: Biochemistry 2100 or Biology 2250; and Biochemistry 2101.

311A/B

Human Physiology

(same as Medicine 310A/B) covers the properties of nerve and muscle cells, the special senses, blood and body fluids, and the nervous, cardiovascular, digestive, immune, respiratory, urinary, endocrine and reproductive systems. Integration of the body's systems in maintaining homeostasis is emphasized. Priority for entry into this course is given to Biochemistry, Nutrition, Dietetics, and other students who are interested in experimental science.

Prerequisite or Co-requisite: Biochemistry 2101.

Lectures: Three hours per week.

Laboratory: To be specified.

Note:

Credit may be obtained for only one of Biochemistry 311A/B or Medicine 310A/B.

3200

Basic Human Nutrition I

studies the nutrients essential to human health and well-being with emphasis on carbohydrates, proteins and lipids, - chemistry, dietary source, dietary requirements, metabolism, and physiological importance.

Prerequisite or Co-requisite: Biochemistry 2101 or Pharmacy 2004 or the former Pharmacy 3110.

Lectures: Three hours per week

3201

Basic Human Nutrition II

studies the vitamins, minerals and trace elements essential to human health and well-being - chemistry, dietary source, dietary requirements, physiological role, and deficiency syndromes.

Co-requisite or prerequisite: Biochemistry 3106 or Pharmacy 3111.

Lectures: Three hours per week

3202

Community Nutrition

examines nutritional assessment, nutrition education, and the role of community agencies and individuals in the dissemination of nutritional information. Survey methods and results will be discussed.

Co-requisites or prerequisites: Biochemistry 3201, and either Biochemistry 311B or Medicine 310B.

Prerequisite: Biochemistry 3200.

Lectures: Three hours per week.

Note:

Credit may be obtained for only one of Biochemistry 3202 and the former Biochemistry 4302.

3402

Food Chemistry

examines the following topics: water structure and the role of water in chemical reactions and mechanical properties of foods; chemistry and physical properties of carbohydrates, proteins and lipids; food dispersions; pigments and natural colorants; food flavour; enzyme properties and applications; vitamins and minerals; chemistry of enzymic and non-enzymic browning; characteristics of: muscle tissue, milk, eggs, bread and edible plant tissue; food additives; and, chemical changes in foods during processing.

Prerequisites: Biochemistry 2000, 2101, and either Chemistry 2440 or Chemistry 2401.

Lectures: Three hours per week.

Laboratory: One period per week.

4002

Biochemical Regulation

examines metabolic regulation at the cellular and multicellular level. Topics will include: control theory; hormones: their biosynthesis and mechanism of action; signal transduction; and, endocrine coordination of metabolic processes. Principles will be illustrated by the use of case studies from the medical and veterinary literature.

Prerequisites: Biochemistry 2100 or Biology 2250; Biochemistry 3106.

Lectures: Two to three hours per week, together with assigned reading and case studies.

4101

Proteins

will review the history of protein research and the general properties of proteins and include other topics such as: strategy and methods for purification; chemical structure, properties, modification and determination of the protein amino acids; sequencing strategy, chain cleavage methods and end group analysis; folding of the protein main chain and techniques to determine structure; and, the relationship between structure and function: protein filaments, motors and regulators. It will also cover disease-related proteins and other examples from the current literature.

Prerequisite: Biochemistry 3105.

Lectures: Two to three hours per week and assigned reading.

4102

Current Topics in Biochemistry

is a seminar course in which faculty and students will discuss topics of current interest in the biochemical literature. Students will be responsible for reading and critically assessing recent literature.

Prerequisites: Admission to this course is restricted to Honours Biochemistry students in their final year or by permission of the Head.

4103

Prokaryotic Gene Regulation

is a detailed and up-to-date treatment of the mechanisms of genetic regulation found in bacterial cells. The course will develop topics based on the evidence of bacterial genetics and modern molecular biological experiments. Topics may include: theory of mutations, RNA transcription, positive and negative regulation of transcription; regulation of protein synthesis; control of DNA replication; bacterial operons and regulons; developmental molecular biology in bacterial systems; and evolution and molecular biology of organelles.

Prerequisite: Biochemistry 3107.

Lectures: Three hours per week.

4104

Eukaryotic Gene Regulation and Developmental Biology

details the cellular and molecular aspects of eukaryotic gene regulation and development. Topics to be covered will include the DNA content and organization of eukaryotes, mechanisms controlling the expression of eukaryotic genetic information at the transcriptional and post-transcriptional levels, and the methodologies used to define these mechanisms. Detailed consideration will be given to the cell-surface events which regulate nuclear gene expression and cell lineage specification. Developmental mechanisms operating in a number of model systems will be discussed.

Prerequisite: Biochemistry 3107 or 3108.

Lectures: Three hours per week.

4105

Immunology

(same as Pharmacy 4105) is taught and administered by the School of Pharmacy. The course is an introduction to the molecular and cellular basis of immunity and hypersensitivity, and will include a discussion of the manipulation of the immune system in the management and treatment of disease.

Lectures/Tutorials: Three per week.

Co-Requisites or prerequisites: Biochemistry 2101, and either Biochemistry 311B or Medicine 310B.

Note:

Credit may be obtained for only one of Biochemistry 4105, Pharmacy 4105 and the former Pharmacy 3105.

4200

Bioenergetics and Biological Oxidation

examines topics such as: respiration and electron transport; the functional organization of energy transducing membranes; the structure and function of flavoenzymes, cytochromes, iron-sulfur proteins and quinones; enzyme reduction of oxygen; and, free radicals in biological systems.

Prerequisite: Biochemistry 3106.

Lectures: Two to three hours per week and assigned reading.

4201

Membranes - Structure and Function

examines the structure of model and biological membranes, the molecular interactions between membrane components and the effects of these interactions on the biophysical and functional properties of membranes. Other topics will include the structure-function of specialized membranous systems, such as lipoprotein, lung surfactant, and lipid rafts; membrane lipid composition in biochemical adaptation and function; and the role of membrane proteins in intracellular trafficking, receptor function, enzymatic activity and membrane-related diseases.

Prerequisite: Biochemistry 3105.

4210

Biochemical Research Techniques I

is designed to familiarize students with methods used for the study of structural and molecular biology.

Prerequisites: Biochemistry 3105, 3107.

Lectures and laboratory periods: times as arranged.

Attendance is required.

4211

Biochemical Research Techniques II

is designed to familiarize students with methods used for the study of cellular and subcellular metabolism. This course may include a research project.

Prerequisite: Biochemistry 3106.

Lectures and laboratory periods: times as arranged.

Attendance is required.

4220

Introduction to General and Autonomic Pharmacology

(same as Medicine 4300) deals with the general principles of pharmacology (dose-response relationship, drug-receptor interaction, absorption, distribution, metabolism, excretion of drugs), and drugs that affect neuromuscular and autonomic neurotransmissin, the cardiovascular, gastrointestinal, and central nervous systems, and autacoids/prostanoids.

Prerequisites: Biochemistry 311A/B or Medicine 310A/B or Pharmacy 2002/2003 (or the former Pharmacy 3201/3202).

Co-requisites: Biochemistry 3106 or Pharmacy 3111.

Lectures: Three hours per week.

Laboratory: Three hours per week.

Note:

Credit may be obtained for only one of Biochemistry 4220 or Medicine 4300.

4300

Advanced Nutrition

is a course in which current controversies and trends in human nutrition are presented and discussed using the scientific literature.

Prerequisites: Biochemistry 3200, 3201, and either Biochemistry 311B or Medicine 310B.

Lectures: Three hours per week.

4301

Nutrition and Disease

is a course which addresses the scientific basis for nutritional intervention in chronic human disease.

Prerequisites: Biochemistry 3200, 3201, and either Biochemistry 311B or Medicine 310B.

Lectures: Three hours per week.

4400

Food Analysis

- inactive course.

4502

Techniques in Nutrition Research

is a seminar course in which faculty and students will discuss concepts and methods used in the study of nutrition. Students will be responsible for reading and critically assessing recent literature.

Prerequisite: Biochemistry 4301.

Admission to this course is restricted to Honours Nutrition students in their final year or by permission of the head.

499A and 499B

Dissertation

is a two-semester linked course (6 credit hours) based on independent study of a problem in Biochemistry. The subject of study will be decided in consultation with Faculty advisors and must be approved in advance by the Department, or both Departments in the case of a Joint Honours degree. This dissertation is obligatory for Honours students in Biochemistry. The dissertation will be submitted as a formal written report accompanied by appropriate illustration before the end of the tenth week of the second semester. Before the end of his/her final semester the student will give an oral presentation of his/her research. Admission to this course is restricted to Honours students in their final year or by permission of the Head.

Note:

Credit may be obtained for only one of Biochemistry 499B or Biochemistry 4999.

4999

Dissertation

is a three-credit hour dissertation for Honours students in Dietetics and Nutrition. The dissertation will be based on independent study of a problem in Dietetics or Nutrition. The subject of study will be decided in consultation with Faculty advisors and must be approved in advance by the Department. The dissertation will be submitted as a formal written report accompanied by appropriate illustrations before the end of the semester. Admission to this course is restricted to Honours students in their final year or by permission of the Head.

Note:

Credit may be obtained for only one of Biochemistry 499B or Biochemistry 4999.