Exploring possible co-receptors of CD24 on developing B cells from the bone marrow.

Kaitlyn Mayne
M.Sc Student
Department of Biochemistry

Date: October 30, 2023
Time: 1:00-2:00 p.m.
Room: CSF-1302

CD24 is a cell surface protein known to be a rheostat in B lymphocyte (B cell) development in the bone marrow through the induction of apoptosis or inhibition of proliferation. However, CD24 lacks an intracellular signaling domain. Currently there are no known co-receptors of CD24 on B cells. Siglec-2 (CD22) and Siglec-G are both inhibitory sialic acid-binding immunoglobulin-like lectins (Siglecs), which are expressed on B cells and are known to interact with glycoproteins such as those on CD24. In other cells such as dendritic cells, Siglec G is a known ligand of CD24, but there is no data to suggest it has any effect on B cells of the bone marrow. CD22 has been found to have similar expression patterns to CD24 on certain developing B cells from the bone marrow, making it a good candidate to explore as a co-receptor. This study will contribute to understanding how CD24 regulates B cell development by aiming to identify its natural co-receptor in developing bone marrow B cells.