Dr. Green started compiling pedigrees on families in Newfoundland and Labrador in which there was a hereditary loss of sight in the 1970s. Since then there has hardly been a study of human genetic disease that she has not been involved with in one capacity or another. Her seminal work on hereditary cancer in the province has spawned several large grants and research endeavours but equally important, it has saved lives, prevented suffering and significantly reduced the provincial health budget.

Over her career Dr. Green has talked with thousands of family members, hundreds of affected individuals and dozens of doctors, nurses and health care providers. She is also an enthusiastic teacher of medical students and medical residents.

Dr. Green has put Newfoundland on the map with her international collaborations, but has always stressed the need and desire for human molecular genetics to be carried out at Memorial University. Her work on hereditary colon cancer paved the way for the Colorectal Cancer Study, a collaboration between Memorial University and Mt. Sinai Hospital, Toronto, ... [She was] also a co-investigator in the Atlantic Medical Genetics and Genomics Initiative, a partnership between researchers at Memorial and Dalhousie University. This project integrates the potential impacts of genetic discovery on the provision of health care services, including assessing the well-being of patients and families who are affected by genetic condition.