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Dr. Jules Doré

{Dr. Jules Doré}
Dr. Jules Doré

Assistant professor
Basic Medical Sciences

Research interests
Dr. Jules Doré's appointment to the Division of Basic Medical Sciences in January brings new strengths in basic cell biology research to the Faculty of Medicine. "A major part of my research is in the basic cellular mechanisms of how cells grow, or more specifically how you make them stop growing," he explained. The hormone he is studying is called transforming growth factor beta. "The odd thing about this hormone is that if you put it on one type of cell, a fibroblast cell, it speeds up growth. But if you put it on other kinds of cells, such as epithelial cells, the same hormone causes the cell to stop growing. Most cells in the body make it and essentially all cells have receptors for it." His work focuses on trying to figure out how transforming growth factor beta can have two opposite effects. "We know it binds to the same receptors and it seems to activate the exact same signaling system in both cell types. For the most part it even activates the same genes, but you get opposite responses depending on the cells involved." This research is particularly relevant to cancer. "Cancer starts with two mutations, but transforming growth factor beta doesn't seem to be involved with either of these two initial events. But as the cancer grows and accumulates more mutations, if one of those mutations happens to be in this system, it's like cutting the brakes on a car already going downhill. In colon cancer, pancreatic cancers and some breast cancers, the prognosis becomes very poor."

Experience
Dr. Doré describes himself as a molecular physiologist applying molecular tools and cell biology methods to address how processes within a cell affect its neighbours, up to the level of organ function.

Background
His background includes undergraduate work at the University of British Columbia (an honours degree in zoology), followed by a master's degree at the University of Florida in animal science. He then returned to Vancouver where he worked for Quadralogic Technologies, a biotechnology company. He went on to do a PhD at the University of Tennessee in reproductive physiology, followed by a post doctoral fellowship at that university. Before joining the faculty at Memorial, he completed a second post doctoral fellowship at the Mayo Clinic where he worked on basic cell biology.

{Memorial University of Newfoundland}