Dr. Garth Fletcher
Bachelors: B.Sc. British Columbia
Antifreeze proteins and cold adaptation in fish. A number of marine fish produce antifreeze proteins to protect themselves from freezing in a sub-zero, ice-laden marine environment. The research we are carrying out focuses on these antifreeze proteins and their physiological regulation mechanisms of action, diversity, evolution and potential economic value in the field of biotechnology.
Hobbs, R.S.; Fletcher, G.L. (2013). Epithelial dominant expression of antifreeze proteins in cunner suggests recent entry into a high freeze-risk ecozone. Comparative Biochemistrya and Physiology A-molecular & Integrative Physiology. 164 (1) 111-118. (Click here for Abstract)
Moreau, D.T.R.; Conway, C.; Gamperl, A.K.; Fletcher, G.L.; Fleming, I.A. (2012). Potential for ecological effects and gene flow resulting from growth hormone transgenic Atlantic salmon (Salmo salar) interactions with wild populations. Transgenic Research. 21 (4) 908-908.
Desjardins, M.; Graham, L.A.; Davies, P.L.; Fletcher, G.L. (2012). Antifreeze protein gene amplification facilitated niche exploitation and speciation in wolffish. FEBS Journal. 279 (12) 2215-2230. (Click here for Abstract)
Lin, F.H.; Sun, T.J.; Fletcher, G.L.; Davies, P.L. (2012). Thermolabile antifreeze protein produced in Escherichia coli for structural analysis. Protein Expression and Purification. 82 (1) 75-82. (Click here for Abstract)
Moreau, D.T.R.; Fleming, I.A.; Fletcher, G.L.; Brown, J.A. (2011). Growth hormone transgenesis does not influence territorial dominance or growth and survival of first-feeding Atlantic salmon Salmo salar in food-limited stream microcosms. Journal Of Fish Biology. 78 (3) 726-740. (Click here for Abstract)
Fletcher, G.L.; Hobbs, R.S.; Evans, R.P.; Shears, M.A.; Hahn, A.L.; Hew, C.L. (2011). Lysozyme transgenic Atlantic salmon (Salmo salar L.). Aquaculture Research. 42 (3) 427-440. (Click here for Abstract)
Butler, T. M.; Fletcher, G. L. (2009). Promoter analysis of a growth hormone transgene in Atlantic salmon. Theriogenology. 72 (1) 62-71. (Click here for Abstract)
Hobbs, R.S.; Fletcher, G.L. (2008). Tissue specific expression of antifreeze protein and growth hormone transgenes driven by the ocean pout (Macrozoarces americanus) antifreeze protein OP5a gene promoter in Atlantic salmon (Salmo salar). Transgenic Research. 17 (1) 33-45.
Levesque, H.M.; Shears, M.A.; Fletcher, G.L.; Moon, T.W. (2008). Myogenesis and muscle metabolism in juvenile Atlantic salmon (Salmo salar) made transgenic for growth hormone. Journal Of Experimental Biology. 211 (1) 128-137.