Genetics & Evolution
Dr Steve Carr (firstname.lastname@example.org)
Office: Sn-3020 (709) 864-4776
Lab: Sn-3007 (709) 864-4713
BSc [Biology], California Polytechnic State University, San Luis Obispo (1975)
CPhil [Genetics], University of California, Berkeley (1978)
PhD [Genetics], University of California, Berkeley (1983)
I am Professor of Biology, with a cross-appointment in Population Genetics to the Faculty of Medicine. Research in my lab focuses on patterns and processes of molecular and genome evolution within and among species of vertebrate animals.
I am interested in supervising honours, MSc, and PhD students in the broad areas of:
1. Phylogeographic genomics of Fisheries & Wildlife populations, including Atlantic Cod, Wolffish, Harp Seals, and Newfoundland Caribou
2. Biogeographic evolution of cods and pollocks (Gadidae)
3. Population genomic structure of the founding human population of Newfoundland, including First Nations peoples
4. Development of a novel biotechnology, Iterative DNA sequencing microarrays for evolutionary & population genomics
My lab has taken a whole-mitochondrial-genome approach to the interrelated problems of population and systematic biology. Phylogeographic analysis of completely-resolved inter- and intraspecific gene trees, based on full-length mtDNA genomes, provides the detailed historical information and necessary statistical power to evaluate vicariance and dispersal phenomena at scales of interest to fisheries, wildlife, and population biologists.
AM Pope, SM Carr, KN Smith HD Marshall (2011). Mitogenomic and microsatellite variation in descendants of the European founding population of the island of Newfoundland: high diversity in an isolated population. Genome, 54,110-119.
SM Carr, AT Duggan, HD Marshall (2009). Iterative DNA sequencing on microarrays: a high-throughput NextGen technology for ecological and evolutionary mitogenomics. Laboratory Focus 13, 8-12.
HD Marshall, MW Coulson, SM Carr (2008). Near neutrality, rate heterogeneity, and linkage govern mitochondrial genome evolution in Atlantic Cod (Gadus morhua) and other gadine fish. Molecular Biology and Evolution 26, 579-589.
SM Carr and HD Marshall (2008). Phylogeographic analysis of complete mtDNA genomes from Walleye pollock (Gadus chalcogrammus Pallas, 1811) shows an ancient origin of Norwegian Pollock. Mitochondrial DNA 19, 490-496.
SM Carr and HD Marshall (2008). Intraspecific phylogeographic genomics from multiple complete mtDNA genomes in Atlantic Cod (Gadus morhua): Origins of the "Codmother," trans-Atlantic vicariance and midglacial population expansion. Genetics 180, 381-389.
SJ Moore, DJ Buckley, A MacMillan, HD Marshall, L Steele, P Ray, Z Nawaz, M Frecker, S M Carr, E Ives, PS Parfrey (2008). The clinical and genetic epidemiology of Neuronal Ceroid Lipofuscinosis in Newfoundland. Clinical Genetics 74,213-222.
SM Carr, HD Marshall, AT Duggan, SMC Flynn, KA Johnstone, AM Pope, CD Wilkerson (2008). Phylogeographic genomics of mitochondrial DNA: highly-resolved patterns of intraspecific evolution and a multi-species, microarray-based DNA sequencing strategy for biodiversity studies. Comparative Biochemistry and Physiology, D: Genomics and Proteomics 3, 1-11.
SMC Flynn, SM Carr (2007). Interspecies hybridization on DNA resequencing microarrays: efficiency of sequence recovery and accuracy of SNP detection in human, ape, and codfish mitochondrial DNA genomes on a human-specific MitoChip. BMC Genomics 8,339.
KA Johnstone, HD Marshall, SM Carr (2007). Biodiversity genomics for Species At Risk: patterns of DNA sequence variation within and among complete mitochondrial DNA genomes of three species of Wolffish (Anarhichas spp.). Canadian Journal of Zoology 85, 151-158.
HD Marshall, KA Johnstone, SM Carr (2007). Species-specific oligonucleotides and multiplex PCR for forensic discrimination of twoof scallops, Placopecten magellanicus and Chlamys islandica. Forensic Science International 167, 1-7.
MW Coulson, HD Marshall, P Pepin, SM Carr (2006). Mitochondrial genomics of gadine fishes: Implications for taxonomy and biogeographic origins. Genome 49, 1115-1130.
SM Carr, HD Marshall, KA Johnstone, LM Pynn, & GB Stenson (2002). How to Tell a Sea Monster: Molecular Discrimination of Large Marine Animals of the North Atlantic. The Biological Bulletin 202, 1-5.
SM Carr, SW Ballinger, JN Derr, LH Blankenship, &JW Bickham (1986). Mitochondrial DNA analysis of hybridization between sympatric white-tailed deer and mule deer in west Texas. Proceedings of the National Academy of Science (USA) 83, 9576-9580
Biol 2250 - Principles of Genetics
Biol 4241 - Advanced Genetics
Biol 3950 - Principles of Biotechnology