Please Enter a Search Term

Publications

You can click on my name to access the abstract/article.

Podder, M.P., Rogers, L., Daley, P.K., Keefe, G.P., Whitney, H.G. and Tahlan, K. (2014). Klebsiella species associated with bovine mastitis in Newfoundland. PLoS ONE. 9(9): e106518. doi:10.1371/journal.pone.0106518.

Boshoff, H. and Tahlan, K. (2013) SQ-109: Treatment of tuberculosis, Cell wall biosynthesis inhibitor. Drugs of the Future. 38: 467-74.

Tahlan, K. and  Jensen, S.E. (2013). Origins of the β-lactam rings in natural products. The Journal of Antibiotics. 66, 401-10.

Kwong, T., Tahlan, K., Anders, C.L. and Jensen, S.E. (2013). Carboxyethylarginine synthase genes show complex cross regulation in Streptomyces clavuligerus. Applied and Environmental Microbiology. 79:240-9.

Xu, T., Willems, W., Au-yeung, C., Tahlan, K. and Nodwell, J.R. (2012) A two-step mechanism for the activation of actinorhodin export and resistance in Streptomyces coelicolor. mBio®. 2012 Oct 16;3(5). doi:pii: e00191-12. 10.1128/mBio.00191-12.

Kwong, T., Zelyas, N.J., Cai, H., Tahlan, K. , Wong, A. and Jensen, S.E. (2012) 5S clavam biosynthesis is controlled by an atypical two-component regulatory system in Streptomyces clavuligerus. Antimicrobial Agents and Chemotherapy. 56:4845-55.

Tahlan, K., Wilson, R., Kastrinsky, D.B., Arora, K., Nair, V., Fischer, E., Barnes, S.W., Walker, J.R., Alland, D., Barry, C.E. 3rd and Boshoff HI. (2012) SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 56:1797-809.

Craney, A., Tahlan, K., Andrews, D. and Nodwell, J.( 2011) Bacterial Transmembrane Proteins that Lack N-Terminal Signal Sequences. PLoS ONE. 6(5): e19421. doi:10.1371/journal.pone.0019421

Backus, K.M., Boshoff, H.I., Barry, C.S., Boutureira , O., Patel, M.K., D'Hooge, F., Lee, S.S., Via, L.E., Tahlan, .K., Barry, C.E. 3rd and Davis, B.G. (2011) Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis. Nature Chemical Biology. 7: 228-35. 

Boshoff, H.I. and Tahlan, K. (2010) Mechanisms underlying mycobacterial infections. Drug Discovery Today: Disease Mechanisms. 7: e1–e3. (Editorial)

Tahlan, K., and Boshoff, H.I. (2009). New cell wall biosynthesis inhibitors under active development for TB. Drugs of the Future, 34: 739-48. (Review)

Zelyas, N., Tahlan, K. and Jensen S.E. (2009). Use of the native flp gene to generate in-frame unmarked mutations in Streptomyces spp. Gene. 443: 48-54.

Tahlan, K., Yu, Z., Yu, Y., Davidson, A.R. and Nodwell, J.R. (2008). Ligand recognition by ActR, a TetR-like regulator of actinorhodin export. Journal of Molecular Biology. 383: 753-61.

Boshoff, H.I., Xu, X., Tahlan, K., Dowd, C.S., Pethe, K., Camacho, L.R., Park, T.H., Yun, C.S., Schnappinger, D., Ehrt, S., Williams, K.J. and Barry, C.E. 3rd. (2008). Biosynthesis and recycling of nicotinamide cofactors in Mycobacterium tuberculosis: An essential role for NAD in non-replicating bacilli. Journal of Biological Chemistry. 283: 19329-41.

Willems, A.R., Tahlan, K., Taguchi, T., Zhang, K., Lee, Z.Z., Ichinose, K., Junop, M.S. and Nodwell, J.R. (2008). Crystal structures of the Streptomyces coelicolor TetR-like protein ActR alone and in complex with actinorhodin or the actinorhodin biosynthetic precursor (S)-DNPA. Journal of Molecular Biology. 376: 1377-87.

Ahn, S.K, Tahlan. K., Yu, Z. and Nodwell J.R. (2007). Investigation of transcription repression and small-molecule responsiveness by TetR-like transcription factors using a heterologous Escherichia coli-based assay. Journal of Bacteriology. 189: 6655-64.

Tahlan, K., Ahan, S.K., Sing, A., Bodnaruk, T., Willems, A.R., Davidson, A.R. and Nodwell, J.R. (2007). Initiation of actinorhodin export in Streptomyces coelicolor. Molecular Microbiology. 63: 951-61. (, Received Commentary)

Tahlan, K., Anders, C., Wong, A., Mosher, R.H., Beatty, P.H., Brumlik, M.J., Griffin, A., Barton, B. and Jensen, S.E. (2007). 5S clavam biosynthetic genes are located in both the clavam and paralogue gene clusters in Streptomyces clavuligerus. Chemistry and Biology. 14: 131-42.

Bignell, D.R.D., Tahlan, K., Colvin, K.R., Jensen, S.E. and Leskiw, B.K. (2005). Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG. Antimicrobial Agents and Chemotherapy, 49: 1529-41.

Wang, L., Tahlan, K., Kaziuk, T.L., Alexander, D.C. and Jensen, S.E. (2004). Transcriptional and translational analysis of the ccaR gene from Streptomyces clavuligerus. Microbiology, 150: 4137-4145.

Tahlan, K., Anders, C. and Jensen, S.E. (2004). The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus. Journal of Bacteriology, 186: 6286-6297.

Tahlan, K., Park, H-U. and Jensen, S.E. (2004). Three unlinked gene clusters are involved in clavam metabolite biosynthesis in Streptomyces clavuligerus. Canadian Journal of Microbiology, 50: 803-810.

Tahlan, K., Park, H-U., Wong, A., Beatty, P.H. and Jensen, S.E. (2004). Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus. Antimicrobial Agents and Chemotherapy, 48: 930-939.

Share