The discipline’s faculty members come from different specialty areas and therefore their research interests are varied. The main themes cover the following focus areas: Cancer, infectious diseases, hematology, clinical chemistry, education, genetics, and artificial intelligence. We have a yearly research day where learners and faculty are invited to share their research findings.

For more information on the research in the discipline, please contact our director Dr. Offiong Ikpatt, 


 Peer Reviewed Publications & Research Activities

January 2021 – April 2022

Peer Reviewed Publications

Moore, C., Barron, J., Manuscript: JNC-2022-0022.R1 Title: Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination. 2022 

Ongoing - Erivwo P, Salama S, Gai L. Mrkonjic M. Armstrong S. Turashvili G. Point-Based Weighted Diagnostic Scale for Histopathologic Assessment of Mammary Cellular Fibroepithelial Lesions. Pending submission

Everard, K., Tate, A., Case Report: A Plasma Cell Neoplasm Imitating a Carcinoid. CJP. 2022 Submitted for second review

Gao Y, Wang C, Merrimen J. (2021) Book Chapter: Genitourinary and Renal Pathology, in the textbook of Pathology Review and Practice Guide 3rd Edition Sent to Publisher, to be published.

Farcas, M, Gatalica, Z, Trpkov, K, Swenson J, Alaghehbandan R, Williamson S, Magi-Galluzzi C, Gill AJ, Tretiakova M, Lopez J, Montiel DP, Sperga M, Comperat E, Brimo F, Yilmaz A, Siadat F,Sangoi A, Gao Y, Ptakova N, Kuthi L, Pivovarcikova K, Rogala J, Agaimy A, Hartmann A, Fraune C, Rychly B, Hurnik M, Durcansky D, Bonert M, Gakis G, Michal M, Hora M, Hes O. (2021) Eosinophilic Vacuolated Tumor of Kidney Demonstrate Sporadic TSC/MTOR Mutations: Next Generation Sequencing Multi-Institutional Study of 19 Cases. Modern Pathology. 2021 September

Boone, Hannah; Gao, Yuan; Fitzpatrick, Madeline; Andrews, Matthew; Rideout, Arthur; Johnston, Paul Primary Non-Cutaneous Melanoma of the Glans Penis: a Case Report Publication in draft

Brenna HL, Kirby SD; Barriers of Artificial Intelligence Implementation in the Diagnosis of Obstructive Sleep Apnea; Journal  Otolaryngology -  Head & Neck Surgery, (2022) 51:16

Grafodatskaya D, O’Rielly DD, Bedard K, Butcher DT, Howlett C, Lytwyn A, McCready E, Parboosingh J, Spriggs EL, Vaags AK, Stockley TL. Practice Guidelines for BRCA1/2 Tumour Testing in Ovarian Cancer. J Med. Genet. 2022 April. 

Pater JA, Penney C, O’Rielly DD, Griffin A, Singh S, Burt T, Abdelfatah N, Houston J, Roslin NM, Vincent D, Marquis P, Woodland G, Stanton SG, Young TL. Splice-altering variant in ATP11A maps to DFNA33 and causes non-syndromic hearing loss. Human Genet. 2022 April.

Woodbury-Smith M, Lamoureux S, Begum G, Nassir N, Akter H, O’Rielly DD, Rahman P, Wintle RF, Scherer SW, Uddin M. Mutational Landscape of Autism Spectrum Disorder Brain Tissue. Genes. 2022; 13(2):207. 

Gill, S. J., Pirzada, A., Power, P., & Neveu, J. (2022). A Constellation of Rare Gynecological Malignancies and Familial Adenomatous Polyposis Gastrointestinal Adenocarcinoma: A Case Report. International Journal of Gynecological Pathology. 

Liu M, Huang Y, Zhang H, Aitken D, Nevitt MC, Rockel JS, Pelletier JP, Lewis CE, Torner J, Rampersaud YR, Perruccio AV, Mahomed NN, Furey A, Randell EW, Rahman P, Sun G, Martel-Pelletier J, Kapoor M, Jones G, Felson D, Qi D, Zhai G. Restricting Branched-Chain Amino Acids within a High-Fat Diet Prevents Obesity. Metabolites. 2022 Apr 7;12(4):334. doi: 10.3390/metabo12040334. PMID: 35448521; PMCID: PMC9030079. 

Werdyani S, Aitken D, Gao Z, Liu M, Randell EW, Rahman P, Jones G, Zhai G. Metabolomic signatures for the longitudinal reduction of muscle strength over 10 years. Skelet Muscle. 2022 Feb 7;12(1):4. doi: 10.1186/s13395-022-00286-9. PMID: 35130970; PMCID: PMC8819943.

Alexander DC, Taylor RM, Martin I, Adam H, Lagacé-Wiens P, Pieroni P, Karlowsky JA, Van Caeseele P. Evaluation of the Hologic Aptima Combo 2 Assay for Detection of Neisseria gonorrhoeae from Joint Fluid Specimens. J Clin Microbiol. 2022 Apr 20;60(4):e0253021. doi: 10.1128/jcm.02530-21. Epub 2022 Mar 23. PMID: 35317619; PMCID: PMC9020330. 

Demczuk, W., Martin, I., Griffith, A., Lefebvre, B., McGeer, A., Tyrrell, G. J., Zahariadis, G., ... & Mulvey, M. R. (2022). Linear Regression Equations To Predict β-Lactam, Macrolide, Lincosamide, and Fluoroquinolone MICs from Molecular Antimicrobial Resistance Determinants in Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy, 66(1), e01370-21. 

Bharat A, Petkau A, Avery BP, Chen JC, Folster JP, Carson CA, Kearney A, Nadon C, Mabon P, Thiessen J, Alexander DC, Allen V, El Bailey S, Bekal S, German GJ, Haldane D, Hoang L, Chui L, Minion J, Zahariadis G, Domselaar GV, Reid-Smith RJ, Mulvey MR. Correlation between Phenotypic and In Silico Detection of Antimicrobial Resistance in Salmonella enterica in Canada Using Staramr. Microorganisms. 2022; 10(2):292.

Research Activities

Tabori, Hawkins, Barron, J., Woods, Etchegary, Gaiti Germline Genetic and Epigenetic Promoter Alterations Predispose to Tissue Specific Mismatch Repair Deficient Cancers. 2022. Research Proposal 

Everard, K., Quality Assurance Project for CBD Regarding Specimens Labelled Urgent 

Everard, K., Starting a Project on Multiple Myeloma in NL with Dr. Ikpatt and Dr. Han 

Fitzpatrick, M., Hematopathology case report (in progress) entitled “A Case of Lymphoplasmacytic Lymphoma Occurring in Association with Crystal-Storing Histiocytosis”. Written in collaboration with Dr. Offiong Ikpatt 

Kirby, S., Social Media Outreach: Otoapproach Educational Podcast Feb 18/2022 

Kirby, S., Social Media Outreach: Twitter as an Educational Tool (resident Dr. Simrin Sennik) Jan 2022 

Kirby, S., Engineering Joint Research: Image Processing – Frozen Section Slide Enhancement Jan 2022

Kirby, S., Molecular Pathology Working Group –Translational Genomics - Eastern Health – March 2022 

Kirby, S., 5H&N Carcinoma Translational Research with Dr. Thomas Belbin – Tumor Banking - Ongoing 

O’Rielly, D., Centre for Translational Genomics Phase I project 

O’Rielly, D., Terry Fox Research Institute Marathon of Hope project 

O’Rielly, D., Genome Canada All4One project 

O’Rielly, D., Genome Canada GAPP IWK Team Validate project 

Randell, E., Work on Development New Metabolomics Assays for Amino Acids, Acylcarnitines, Vitamins and Organic Acids 

Sennik, S., Twenty-year incidence trend of hematologic malignancies in Newfoundland and Labrador, Canada: A Retrospective Review. Supervisor: Dr. Offiong Ikpatt, Memorial University of Newfoundland. 2022 

Sennik, S., The Use of Twitter as an Educational tool in Pathology Residents: Assessing its current use, fostering its use in an experimental group using learning theories, post experimental assessment and applications. Supervisor: Dr. Vernon Curran, Memorial University of Newfoundland. 2022 

Sennik, S., Clinical and Pathological prognostic factors of vulvar and vaginal melanomas. Primary Investigator: Dr. Allison Osmond, Dermatopathologist at the University of Saskatchewan. 2022 

Taylor, R., Participating author for “Antimicrobial Susceptibility of 56,936 Pathogens Isolated from Patients in Canadian Hospitals: 15 Years of the CANWARD Study 2007-2021” (Poster, World Microbe Forum, 2022) 

Taylor, R., Lead author for “Antimicrobial Susceptibility Patterns in Urinary Tract Infection Isolates across Canadian Hospitals: Results from CANWARD 2009-2019” (Poster, CACMID, 2022) 

Zern, C., April 2022 to current (in progress, working with Dr. Tzafriri): A Rare Case of Harlaftis Type 1, Boyden’s “Vesica Fellea Divisa”  Bilobed  Gallbladder and Common, Septated, Cystic Duct with Acute (Focally Necrotizing) and Chronic Cholecystitis and Cholelithiasis- Case Report with Literature Review. 

Yu, Y., CIHR (Multicenter Trial, co-investigator MUN/EH site).  The S. aureus Network Adaptive Platform Trial (SNAP) Canada: A Randomized Controlled Trial for Penicillin-susceptible, Methicillin-susceptible, and Methicillin-resistant Staphylococcus aureus Bloodstream Infections in Hospitalized Patients 

Yu, Y., CanCOGeN: The Canadian COVID Genomics Network VirusSeq.