Bio4241
- Advanced Topics in Genetic Analysis
E-mail: scarr@mun.ca
Notes for Bio2250
(Principles of Genetics)
Research in
my lab
This course is an extension of Bio2250 to
advanced topics in modern Genetics &
Genomics.
Bio4241, Winter
2012 semester
Course Syllabus
Course Schedule &
Outline (Lectures TuTh
1030-1145, En-1052;
Lab
Wed 1400-1700,
Sn-4117)
Presentation
Schedule & Class List
[update TBA]
Midterm
Exam Questions: 29 Feb 2012 [answer 2 of 4]
Final
Exam Questions (sample) : 05 April 2012 [answer 3 of 5 questions]
Basics
of
webpage construction: a tutorial on pages, links, & images
Creating a webpage on the MUN
server: publishing your webpage
http://www.biol4241.com : an editable domain for student
presentations
Introduction
to Advanced Topics in Genetics
- [11 &18 Jan Labs] Sn-4117 - Webpage construction &
posting to the server
- [12
& 17 Jan] Advanced
Topics in Mutagenesis
- [19 Jan] The Genetic Code & its role in protein
synthesis [see "Cracking
the Code"]
Student Presentations
See the Nobel e-Museum for
biographies, summaries & other resources
See PubMed at NCBI for papers
Historical material & animations at Cold
Spring Harbor Labs DNA Learning
Center
- (1) [24 Jan] Genetic function of DNA
- see also: Hershey & Chase (1952).
Genetic recombination and heterozygosis in bacteriophage. Cold Spring Harbor Symp Quant
Biol 16: 471-479.
- (2) [26 Jan] Replication of DNA
- (3) [31 Jan]
Intron
/ Exon structure: "Split
Genes"
- Garapin, Cami, Roskam, Kourilsky,
Le Pennec, Perrin, Gerlinger, Cochet, & Chambon (1978). Electron
microscopy and restriction enzyme mapping reveal additional
intervening sequences in the chicken ovalbumin split gene. Cell 14:629-639 [PDF of original] [PDF of
presentation] Posted 31 Jan
- (4) [02 Feb] Transposable elements: "Jumping Genes"
- [Barbara
McClintock]
- see also: Evelyn
Fox Keller (1983) A
Feeling for the Organism: the Life and Work of Barbara
McClintock. WH Freeman..
- (5) [07 Feb] Molecular Evolution: "Apes & Humans are 99%
similar"
- King & Wilson (1975).
Evolution at two levels in humans and chimpanzees. Science 188:107-16. [PDF of original] [PDF of
presentation] Posted
- (6) [09 Feb]
Dideoxy-chain-termination DNA sequencing: "ACGT..."
- Sanger, Nicklen, &
Coulson (1977). DNA
sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA
74:5463-5467. [PDF of original] [PDF of
presentation] Posted
- (8) [14 Feb]
DNA Fingerprinting
- Jeffreys, Wilson, &
Thein (1985). Individual-specific 'fingerprints' of
human DNA. Nature 316:76-79. [PDF of original]
[PDF
of presentation] Posted
- (7) [16 Feb] IonTorrent Personal
Genome Machine: Next Generation DNA
sequencing -
- Rothberg et al. (2011) An
integrated semiconductor device enabling non-optical genome
sequencing. Nature
475: 348–352 [PDF of original] [PDF of
presentation] Posted
Winter Break, 20 - 22 Feb: no
classes
Part II: AW
Griffiths et al.,
2002. Modern Genetic Analysis, 2nd ed. Presentation
Schedule
- Chapter 07 [23 Feb]
Bacteriophage & Bacterial Genetics [PDF] [Group 1]
- Chapter 12 [28 Feb]
Mutational Dissection [PDF] [Group 2]
- 29 Feb
MIDTERM EXAM [2-3P, Lab Period]
- Chapter 13 [01 Mar]
Gene Regulation [PDF] [Group 3]
- Chapter 15 [06 Mar]
Regulation of Cell Number: Cancer [PDF] [Group 4]
- Guest
[08 Mar]
Guest
Lecture:
TBA
- Chapter 16
Genetics of Complex phenotypes:
- [13 Mar]
Binary Fate & Sex Determination [PDF] [Group 6]
- [15 Mar]
Complex Pattern Formation [PDF] [Group 5]
- Chapter TBA
Post-Modern Genetics
- [20 Mar]
NextGen sequencing [PDF] Group 7
- [22 Mar]
Bioinformatics [PDF] Group 8
- SMC [27
Mar]
Genetics, Evolution,
& Language: Origins of Human Diversity [Tishkoff et al. 2009] posted
- Chapter 18
Quantitative &
Behavioural Genetics posted
- [29 Mar]
SMC: Quantitative
& Behavioural Genetics posted
- [03 Apr]
Ainsley Latour on Hamer
et al. 1993.
A linkage between DNA
markers on the X
chromosome and male sexual orientation.
- lod scores:
localizing genes
of interest from genomic data
Last updated 10
February 2012
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