Dr. William R. Driedzic
Bachelors: B.Sc. York
Masters: M.Sc. Toronto
Doctoral: Ph.D. U.B.C.
Telephone: (709) 864-3282
E-mail: wdriedzic@mun.ca
List all publications
Research Interests:
My research interests focus on the impact of environmental challenge, especially low oxygen and temperature extremes, on metabolic pathways. Current activities include: cardiac adaptations to anoxia, glycerol as a protective agent against low temperature, and control of protein synthesis. Experiments are conducted with a range of animals and tissues and at different levels of organization ranging from isolated proteins to whole animal cardiovascular performance. Furthermore, studies are designed to exploit the unique properties of selected marine organisms to lend fundamental insights into human disease issues such as diabetes and myocardial ischemia.
Recent Publications:
Treberg, J.R.; Stacey, J.E.; Driedzic, W.R. (2012). Vanadium accumulation in ascidian coelomic cells is associated with enhanced pentose phosphate pathway capacity but not overall aerobic or anaerobic metabolism. Comparative Biochemistry And Physiology B-biochemistry & Molecular Biology. 161 (4) 323-330. (Click here for Abstract)
Hall, J.R.; Short, C.E.; Rise, M.L.; Driedzic, W.R. (2012). Expression Analysis of Glycerol Synthesis-Related Liver Transcripts in Rainbow Smelt (Osmerus mordax) Exposed to a Controlled Decrease in Temperature. Physiological And Biochemical Zoology. 85 (1) 74-84. (Click here for Abstract)
Clow, K.A.; Driedzic, W.R. (2012). Glycerol uptake is by passive diffusion in heart but by facilitated transport in RBCs at high glycerol levels in cold acclimated rainbow smelt (Osmerus mordax). American Journal Of Physiology - Regulatory, Integrative And Comparative Physiology. [This publication is currently 'In Press']
Huansheng, G.; Croft, K.; Driedzic, W.R.; Ewart, K.V. (2011). Chemical chaperone action of glycerol on the antifreeze protein of rainbow smelt (Osmerus mordax). Journal Of Thermal Biology. 36 78-83.
Ditlecadet, D.; Short, C.E.; Driedzic, W.R. (2011). Glycerol loss to water exceeds glycerol catabolism via glycerol kinase in freeze resistant rainbow smelt (Osmerus mordax). Journal Of Physiology- Regulatory, Integrative And Comparative Physiology. 300 (3) R674-R684. (Click here for Abstract)
Robinson, J.L.; Hall, J.R.; Charman, M.; Ewart, K.V.; Driedzic, W.R. (2011). Molecular Analysis, Tissue Profiles and Seasonal Patterns of Cytosolic and Mitochondrial GPDH in Freeze Resistant Rainbow Smelt (Osmerus mordax). Physiological And Biochemical Zoology. 84 (4) 363-376. (Click here for Abstract)
Gendron, R.L.; Armstrong, E.; Paradis, H.; Haines, L.; Desjardins, M.; Short, C.E.; Clow, K.A.; Driedzic, W.R. (2011). Osmotic pressure-adaptive responses in the eye tissues of rainbow smelt (Osmerus mordax). Molecular Vision. 17 ( 279-82) 2596-2604. (Click here for Abstract)
Gong, H.S.; Croft, K.; Driedzic, W.R.; Ewart, K.V. (2011). Chemical chaperoning action of glycerol on the antifreeze protein of rainbow smelt. Journal Of Thermal Biology. 36 (1) 78-83. (Click here for Abstract)
Hall, J.R.; Clow, K.A.; Rise, M.L.; Driedzic, W.R. (2011). Identification and validation of differentially expressed transcripts in a hepatocyte model of cold-induced glycerol production in rainbow smelt (Osmerus mordax). American Journal Of Physiology-regulatory Integrative And Comparative Physiology. 301 (4) R995-R1010. (Click here for Abstract)
Richards, R.C.; Short, C. E.; Driedzic, W. R.; Ewart, K. V. (2010). Seasonal changes in hepatic gene expression reveal modulation of multiple processes in Rainbow smelt (Osmerus mordax). Marine Biotechnology. 12 (6) 650-663. (Click here for Abstract)
