Gene Therapy, Genetic Testing, and Uses of Genetic Information - Case J2
Dr. Freitag believes she has uncovered a highly predictive marker and wishes to conduct a special project in which she would characterize the inheritance of the marker in families with a history of Huntington's disease. This project will confirm the predictive value of the marker.
- Given the moderate uncertainty with regard to the predictive value of the marker, what should Dr. Freitag tell her research subjects when she finds that they have the genetic marker? What if the marker were predictive in every case? How might she involve patients in this decision and what issues might they consider?
- Assume this is not a project of research, but a diagnostic procedure in which the predictive value of the marker were certain. If you knew you had a 50% probability of inheriting the defective gene, would you choose to take this test? Why or why not?