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Dr. Daniel MacPhee

{Dr. Daniel MacPhee}
Dr. Daniel MacPhee

Assistant professor
Basic Medical Sciences
Faculty of Medicine

Main research interests
Dr. MacPhee studies the molecular mechanisms of uterine function during pregnancy, and placental development — especially in conditions like pre-eclampsia. These interests in developmental biology fit well with existing strengths of researchers in the Terry Fox Cancer Laboratory. Both of his research interests have implications for better understanding the molecular mechanisms underlying human pregnancy, and he is in the process of contacting faculty in obstetrics and gynecology to proceed with work more implicated with human development.

Dr. MacPhee also has broad experience with confocal laser-scanning microscopes. Last year the Medical School Laboratories opened the Confocal Digital Imagery Centre, a self-contained facility within the Histology Unit which houses an upright and inverted microscope capable of bright field, dark field, phase contrast, DIC and fluorescence microscopy. "I'd be happy to collaborate with faculty in terms of learning how to use this machine efficiently," he said. "Every different research interest requires slightly different procedures and a lot of my experience has been in troubleshooting those kinds of problems." Dr. MacPhee is enthusiastic about the potential uses of the Confocal Digital Imagery Centre. "Through this equipment we can look at live cells as well as tissues."

Dr. MacPhee earned a B.Sc. (Hons.) from UPEI, becoming involved in marine biology research during summer jobs. Wanting to move into mammalian development, he went on to do a PhD at the University of Western Ontario in mouse development, followed by two post-doctoral fellowships - the first at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital in Toronto, and the second at the Department of Biochemistry at the University of Western Ontario.

{Memorial University of Newfoundland}