Recall Holiday-Whitehouse Model of DNA recombination (animation)
Consider a pair of
chromosomes, each with a (CAG)4 repeat
Suppose repeat
regions of homologous strands align "out of register"
Recombination within this
region produces a (CAG)6 and
a (CAG)2 chromosome
Further slippage in the (CAG)6 chromosome
may
lead to chromosomes with multiple (10s ~ 100s) of repeats.