History of Developmental Biology

Determinative vs Regulative Development

    W Roux (1850 - 1924)
       Mosaicism of "Half"-Frog embryo (1888 experiments)

    H Driesch (1867 - 1941)
        Pluripotency of 4-cell sea urchin embryos (1892 experiments)

    H Spemann (1869 - 1941) [Nobel, 1935] -   Micro-surgical techniques
        Grey Crescent - determination of Dorsal / Ventral axis
        Induction of Eye - epidermal structures induced by endodermal tissue
        Organizer Principle & H Mangold - determination of three-layered gastrula embryo

        RM Eakin (1910 - 1999) "Great Scientists Speak Again: Hans Spemann" [online video]

HOMEWORK:
        What is the original distinction between Organic & Inorganic chemistry, as compared to the present distinction?
        Compare and contrast Vitalism with Reductionism as theories of the development of living beings.
        "Great Scientists": to what extent are scientific advances due to the personality & historical circumstances of individual researchers?

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