Conformational changes of enzymes during catalysis

    In the uninduced form of the enzyme [left], three crucial amino acid residues in the active site are relatively far apart [left]. During induction of enzymatic activity [right], the active site residues shift closer to each other so as to bind the substrate in the enzyme-substrate complex, as predicted by the induced-fit model.

Figure © 2002 by Griffiths et al. ; All text material ©2011  by Steven M. Carr