Induced-Fit Model of enzyme catalysis

    Active sites in the uninduced enzyme are shown schematically with rounded contours. Binding of the first substrate (gold) induces a physical conformational shift (angular contours) in the protein that facilitates binding of the second substrate (blue), with far lower energy than otherwise required. When catalysis is complete, the product is released, and the enzyme returns to its uninduced state.

    The induced fit model has been compared to a hand-in-glove model, wherein it may be difficult to insert the first finger into the proper place, but once done, the other fingers go in easily because the glove is now properly aligned.

All text material ©2009  by Steven M. Carr