Induced-Fit Model of enzyme catalysis
Active sites in the uninduced enzyme are shown schematically with rounded contours. Binding of the first substrate (gold) induces a physical conformational shift (angular contours) in the protein that facilitates binding of the second substrate (blue), with far lower energy than otherwise required. When catalysis is complete, the product is released, and the enzyme returns to its uninduced state.
The induced fit
model has been compared to a hand-in-glove
model, wherein it may be difficult to insert the first finger
into the proper place, but once done, the other fingers go in easily
because the glove is now properly aligned.