DNA probes specific to regions of
Individual chromosomes may be tagged with fluorescent markers and hybridized
with a chromosome spread. In this computer-enhanced image, chromosome spreads
from a single individual are identified sequentially by the use of a series
of probes tagged with the same fluorchrome. In the amplified view at right,
male and female karyotypes are readily distinguished by hybridization with
X- and Y-specific probes. By adjusting the fluorescence wavelength of the different tags, chromosomes may also be identified
simultaneously by the technique of Chromosome
Painting.
