Strategic Institutional Research Initiatives (SIRI) oversees all aspects of the Canada Research Chairs Program (CRC), the Canada Foundation for Innovation (CFI) and other large-scale institutional funding programs. It also promotes and facilitates the nomination of faculty and staff for prestigious honours with the intent of increasing and highlighting Memorial’s reputation and research success.

SIRI also supports Memorial’s CREAIT Network, a university-wide network designed to maximize the impact of Memorial's institutional investments in research through enhanced access to, and utilization of, major research equipment.