Change in frequency
of A1 in the case of heterozygote
advantage
W11 = 0.2, W12 = 1.0,
W22 = 0.4
Heterozygote advantage occurs when the
fitness of the heterozygous genotype is superior to that of
either homozygote. This is also called "Overdominance," which
is misleading because genotypes do not "dominate"
other genotypes. For the initial values of f(A1)
= 0.001, 0.1, 0.9, 0.999, as shown, p will
converge rapidly on an equilibrium
value (
: read "p hat")
where 
p
= 0.0. The equilibrium is calculated as 
= (1 - W22)
/ (2 - [W11 + W22]),
provided the fitness of the heterozygote has
been normalized as W12 =
1.0. In this case, = (1.0 -
0.4) / (2 - (0.2 + 0.4)) = (0.6 / 1.4) = 3 / 7 = 0.428571428571
= 0.43.
In terms of selection coefficients s1 and s2 against
the A1A1
and A2A2
genotypes, respectively, = s2 / (s1
+ s2), again
provided the fitness of the heterozygote has been normalized
to 1. In this case, s1
= (1 - W11) = (1.0 -
0.2) = 0.8
and s2 =
(1 - W22) = (1.0 - 0.4) = 0.6. Then s2
/ (s1 + s2)
= (0.6) / (0.8 + 0.6) = 3 / 7 as
before.
In both cases, note that the
numerator for calculation of of the A1
allele involves the fitness expression for the alternative A2
allele. The more typical calculation of
thus
uses the expression for the A1
allele.