IG3_02_13
A+T and G+C base pairs have similar structures

    The combination of a two-ring purine (A or G) and a single-ring pyrimidine (T or C) forms a base pair (A+T or G+C ) with three co-planar rings. The distance between the backbones and the orientation of the bonds to the deoxyribose are essentially identical for either pair.

    The A+T pair is held together by two H-bonds versus the G+C with three. A convenient mnemonic is that "A" has two "toes" paired to the two "ears" of the "T". G and C are rounded: "G" has the two ends in "C", plus the crossbar, for three bonds.

    The bases are often represented as different colors, according to conventions adopted for computer visualization in the first generation of automated DNA sequencer. In this scheme, A C G T . The yellow G is easy to read against a black background on a sequencer computer screen
, but when written on paper is represented by a black G. Rendered this way, the AT pair shows "Christmas" colors, and the GC pairs shows "Easter" colors.


    [It was not appreciated for a number of years that this color scheme made life difficult for red-green color-blind male scientists. Modern machines offer a choice of visualization colors that avoid this problem].



Figure © 2012 TA Brown, Introduction to Genetics (1st ed.); additional text © 2024 by Steven M. Carr