Reciprocal
translocation in CML (Chronic Myologenous Lukemia):
the Philadelphia
Chromosome
Standard Chromosomes 9
& 22 are shown at left: they are subject to
breakage at the abl and bcr loci,
respectively. The so-called Philadelphia Chromosome is detectable
cytologically as an extra G-group
chromosome due to the apparent shortening of the F-group Chromosome
22 by a reciprocal exchange with Chromosome 9.
Juxtaposition of the abl and bcr loci
interferes with cancer suppressor genes (oncogenes),
and results in a specific form of cancer, Chronic
Myologenous Leukemia (CML).
Philadelphia Chromosome was one of the first genetic conditions shown to be associated with cancer.
Philadelphia Chromosome was one of the first genetic conditions shown to be associated with cancer.