Derivation of the Hardy-Weinberg Theorem

In a monoecious species, for a single locus with two alleles A & a:

    Let frequency of A allele f(A) = p
    Let frequency of a allele f(a) = q
    Let allele frequencies in males & females be equal (qm = qf).
 
    What are the expected genotype frequencies after one generation of random union of gametes?


I. What are the probabilities of obtaining various gametic combinations?
                  prob. of A from male & A from female:     pm x pf = p2
                  prob. of a from male & a from female:      qm x q = q2
                  prob. of A from male & a from female,
                           or  a from male & A from female:     (pm x qf ) + (pf x qm ) = 2pq


II. What is the result of the binomial expansion of p & q in males & females

                  (pm + qm) (pf + qf) = p2 + 2pq + q2


III. What are the areas of the four boxes in a Punnet Square? [SR2019 3.1]


Recall that in Mendelian genetics the Punnet Square shows the results of a single cross between two Aa individuals, in which case the square is divided into four equal quarters, each representing 1/4 of the offspring. In a population of individuals with allele frequencies p & q, the two axes are divided as the relative proportions of p & q. Then, the areas of AA, Aa, and aa are
p2, (pq + pq) = 2pq, and q2.

By any of the three methods:    f(AA) = p2         f(Aa) = 2pq        f(aa) = q2


HOMEWORK: Repeat all three derivations, using the notation  f(a) = q, and f(A) = (1-q)

All text material © 2021 by Steven M. Carr