**What is the ratio of deleterious
recessive
homozygotes**

** in an inbred versus
a non-inbred population?**

If **F = 0** (population is not
inbred)
then

q^{2}_{exp} / q^{2}_{obs} = 1

if **F > 0** (population is
inbred)
& **q** << 1 then

q^{2}_{exp}
/ q^{2}_{obs} = (q^{2} + Fpq) / q^{2 }
(q^{2} + Fq) / q^{2} = (q + F) /
q **
F/q**

*Ex*.: if q
= 10^{-4} & F = 0.01 then
**F/q**
= 10^{2 }= **100**

** i.e.,
a
very small degree of inbreeding results in a 100-fold increase in the
proportion of deleterious homozygotes**

Text material © 2007 by Steven M. Carr