is usually rare (allele frequency
is usually present in heterozygous genotypes
Condition often occurs in matings
of related individuals consanguineous
marriage - at least one ancestor in common "inbreeding" - consanguineous
marriages occur more frequently than expected
often "skips generations"
mitochondrial DNA (mtDNA) is a cytoplasmic (non-nuclear)
genome Clues: occurs in all descendants of an affected female
do not transmit the
in 2012; not on final exam]
Calculation of Risk in
pedigree analysis involves simple probability theory
The probability of two independent events occurring together ("A andB")
is the product
of the separate probabilities
The probability of two alternative events
occurring together ("A or
is the sum
of their separate probabilities
The a priori
probability of events may be modified by a posteriori
calculation of the probability of single events is often
influenced a posteriori
Homework: In the following pedigrees,
which modes of inheritance can be ruled out?
allow you to do so? Which are possible? Which is most likely? Explain.
the genotypes of each of the individuals.