Research at the Park Lab

Structural and Functional Studies of Metabolic Enzymes

We study allosteric enzyme regulation, its significance in biological pathways, and its utility in drug discovery. Our working hypothesis is that allosteric enzymes are more prevalent than currently perceived in essential metabolic pathways. We are particularly interested in the enzymes of isoprenoid synthesis and sugar phosphorylation. Our scientific methods mainly involve enzyme kinetics and protein X-ray crystallography.

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