Adiposopathy as an independent predictor of insulin resistance

Although obesity increases the risk of insulin resistance and diabetes, not all obese patients suffer from these conditions. Beyond adiposity (the amount of adipose tissue) and the anatomical distribution of adipose tissues throughout the body (for example, visceral vs subcutaneous), the functional state of the various adipose tissue depots must play a role. Our recent work shows that perturbed adipose tissue dysfunction, adiposopathy, is in fact an independent predictor of insulin resistance in humans. Improving the functional state of adipose tissue could be an interesting target in the fight against obesity-related comorbidities.