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Mass Spectrometry

The facility has five mass spectrometers with a number of sample introduction options (GC,LC and CE), ionization sources and analyzer types to allow analysis over a large mass range from small molecules to large proteins. Three of the instruments have TOF (time-of-flight) analyzers providing high sensitivity and resolution for accurate mass determinations. The LCMS systems have the option of ESI,APCI or APPI ionization sources.

Potential users of the facility are encouraged to meet with the operator prior to training to discuss the scope and nature of their work to determine the most appropriate instrument choice. Access to the lab is limited to 9:00am to 5:00pm Monday to Friday. More experienced users may request 24/7 access.

LC/MSD (TOF) Agilent 6200 series Accurate- Mass-Time- of- Flight

• HPLC ( 1260 Infinity) interfaced to a 6230 TOF MS (an orthogonal time-of-flight analyzer)
• HPLC equipped with vacuum degasser, quaternary pump, autosampler and variable wavelength detector (190-600nm)
• MS has Dual Electrospray (dual-ESI) and Atmospheric Pressure Photoionization ( APPI) chambers
• Ion detection in positive , negative and fast polarity switching modes
• Software: MassHunter Workstation version B.05.01

LC/MSD (Trap) Agilent 1100 series SL

  • HPLC ( 1100 series) interfaced to an ion trap mass analyzer ( model G2445D SL)
  • LC equipped with a vacuum degasser, quaternary pump, thermostatted auto sampler and UV-VIS diode array detector ( wavelength range 190-900nm)
  • MS has Electrospray (ESI) and Atmospheric Pressure Ionization (APCI)
  • MS has an ion trap analyzer with mass range 50-2200 Da with adjustable scan speeds for normal,enhanced or maximum resolution and extended range 50-4000 Da with normal resolution
  • Scan, Multiple Ion Monitoring (MRM) and MS(n) modes with positive, negative and alternating polarity ion detection
  • Sample introduction via LC or syringe pump for direct infusion experiments and optimization
  • Software: ChemStation for LC 3D Rev.A.10.02 [1757] , Bruker MSD Trap Control Version 5.2 Build No. 63.8

GCMS Agilent

  • GC (model 6890N) interfaced to a single quadrupole 5973 inert MSD (model G2578A)
  • GC has a split/splitless injector with electronic pneumatic control and autosampler
  • MS has a quadrupole mass analyzer with a mass range of 1.6-800 Da
  • SIM( single ion monitoring ) and scan mode available with positive ion detection
  • Software: MSD ChemStation D.01.00 Build 75

CE (CE/MS) Agilent 7100 series

  • Equipped with a UV-VIS diode array detector (wavelength range 190-600 nm)
  • Standalone mode or interfaced with the Agilent 6200 series Accurate- Mass- TOF- ms
  • Software: OpenLAB CDS chemstation edition for CE and CE/MS systems Rev.C.01.05(43)


4800 MALDI TOF/TOF Applied Biosystems/MDS SCIEX

  • MALDI (matrix assisted laser desorption ionization) instrument features tandem TOF (time-of -flight) analyzers
  • Variable ion path length to accommodate MS linear, MS reflector and MS/MS modes
  • Nd:YAG laser operates at 355nm to ionize samples
  • positive and negative ion detection
  • High-resolution precursor selection (MS/MS mode)
  • Automated single-plate sample-loading system
  • Software: 4000 Series Explorer V3.5.3 ( Build 1017)