The major research interests of the School of Pharmacy are: medicinal chemistry - development of more selective nucleoside analogues and study of membrane transport metabolism as well as pharmacokinetics of the mucleoside analogues; pharmaceutics - studies of novel drug delivery systems such as transdermal iontophoresis and phonophoresis, electropororation, lipid pathway transport and targeting hydrophobic drugs; nneuropharmacology - studies of the spinal pharmacology of pain modulation and analgesia, abnormal sensory processing in an acute experimental model of neural injury pain, and drug-inducted spinal neurotoxicity; and drug metabolism/toxicology - a study of the pharmacology, toxicology and molecular biology and cytochrome P450 monoxygenases with emphasis on the roles of hormones and exogenous chemicals.
KARA, Mohamedtaki Associate professor
Keywords
• Electrically-enhanced transdermal drug delivery; iontophoresis
and electroporation; GI drug delivery and interactions
Current research
• Iontophoretic transdermal delivery
• Transdermal drug delivery by electroporation
• Efflex transporters in the GI tract
Past research
• Therapeutic drug monitoring
• Gastrointestinal drug interaction with metal ions and complex
drug molecules
Potential research
• Localized iontophoretic drug delivery
• Electroporative delivery of protein/peptide drugs and gene
therapy
LAW, Rebecca M. Associate professor
Keywords
• Neonatal drug use; interdisciplinary education; pharacokinetic
and pharmacodynamic modelling
Current research
• Pain management in the neonate
• Toxicity of local anesthetics in the neonate
• Analysis relating to interdisciplinary education
Past research
• Toxicity of local anesthetics in the full-term baby
• Empiric dosing guidelines for Vancomycin in premature neonates
• Drug-related pharmacolcinetics and pharmacodynamics of
prednisolone
• Sterility and pyrogenicity of IV nitroglycerin
Potential research
• Pharmacolcientic and pharmacodynamic modelling
• Drug treatments and toxicity in neonates
• Drug treatments in dermatology
LIU, Hu Associate professor
Keywords
• Drug targeting; design and synthesis of prodrugs; diagnostic
imaging (atheroma and cancer); drug analysis; biochemistry; lipid
and lipoprotein metabolism; protein chemistry; NMR analysis in
biological systems; natural product chemistry
Current research
• Anticancer drug targeting
• Development of targeted radioimaging probes for early detection
of atherosclerosis
• Reversion of multidrug resistance in cancer therapy
Other research activities
• Peer review panel member for the Pharmaceutical Sciences
Committee
of the Medical Research Council of Canada
RAWSON, Nigel (see Medicine)
SHAHIDI, Fereidoon (see Biochemistry)
TIRUNELLAI, Krishnan Associate professor
Keywords
• Biopharmaceutics and drug delivery; peptide drug delivery;
electroporative transdermal drug delivery; polymeric mucosal drug;
delivery; solid phase extraction; bioavailability
Research specialty
• Drug delivery
Current research
• Transdermal delivery of peptides using electrical energy
as transport enhancers
• Polymeric mucosal drug delivery, microspheres and bioadhesives
• Development of analytical methods using solid phase extraction
techniques, for
instance preparation of biological origins
Past research
• Use of polymers as excipients for improving bioavailability
of drugs
• Use of pigs as models for pharmacokinetic evaluation of
orally delivered formulations
• Development of analytical methods using solid-phase extraction
techniques
WANG, Lili Assistant professor
Keywords
• Drug transport; drug metabolism; drug design; pharmacokinetics;
radiopharmacy
Current research
• Specific delivery of anti-HIV agents to macrophages
• Design of diagnostic agents for early detection of atherosclerotic
lesions
• Targeted delivery of anti-cancer drugs
• Design of novel anti-HIV compounds
• Study of the transport of nucleoside drugs
Past research
• Evaluation of prodrugs for nucleoside drugs
• Pharmacokinetics of steroids
• Cytotoxicity of nucleoside drugs
WEST, Roy (see Medicine)
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