RResearch interests in the Faculty of Medicine are wide
in scope, spanning the divisions of
clinical sciences, basic medical sciences and community medicine/
behavioural sciences.
Several research groups have been established within the faculty,
including immunology, cell molecular biology, cardiovascular physiology,
oncology, neuroscience, population-based epidemiology, clinical
epidemiology and health services delivery. While the faculty's
research, including graduate program offerings and recruitment,
tends to focus on these groupings, research developments in a
variety of medical scientific areas are ongoing: hypertension,
stroke, kidney disorders, arthritis, cancer therapy, human genetic
disorders, autoimmunity, Alzheimer's disease, diabetes, mental
disorders, heart disease, epilepsy, nutritional disorders, hepatitis
and organ transplantation.
ADAMAC, R (see Psychology)
ADAMS, G. B. Professor
Keywords
• Hemetology
Current research
• Hodgkin's disease, NCIC Clinical Trial
• Multiple myeloma, NCIC Clinical Trial
• Acute myelogenous leukemia, CLSG Clinical Trial
ALDERDICE, Catherine Associate professor
Keywords
• Rheumatology; arthritis; osteoporosis
Current research
• Long-term study of safety of daily subcutaneous injections
of Anakinra (r-metHull-Ira) in patients with RA
Past research
• Use of capillary microscopy in connective tissue disease,
Naproxen study
• Family study of Raynaud's phenomenon
• Scleroderma and clotting factor abnormalities
• Randomized comparison of Isonxican and Ibuprofen in the
treatment of rheumatoid arthritis
• Tenidap study
• Residronate study
• MK-0966 versus Diclofenac Sodium study
• Celecoxib study
ANDREWS, Wayne Professor
Keywords
• Nutrition in the premature infant
Current research
• Oxidative stress and early visual functioning in very low
birth weight infants
Past research
• Evaporated milk formula and infant nutrition
• Visual acuity development and fatty acid composition of
erythrocytes in full-term breast-fed babies
• Zinc-iron interaction in premature infants
• Laboratory gloves as source of trace element contamination
• Zinc absorption in premature infants
• Vitamin intakes in externally-fed premature infants
• Meeting iron requirements of parenterally fed, very low
birth weight infants
Potential research
• Nutrition and premature infants
AZIZ, Khalid Assistant professor
Keywords
• Neonatology; neonatal outcomes; neonatal nutrition; neonatal
sepsis
Current research
• Neonatal heart rate variability
• Iron supplementation of breastfed infants
Past research
• Colonization rates for GBS
• Outcomes of VLBW infants in relation to cerebral ultrasound
• Trace-element levels in VLBW infants
Potential research
• Utility of heart rate; blood pressure; blood flow variability
• Outcomes in iron-deficient infants
• Antioxidants in preventing neonatal morbidity
BARRETT, Brendan Associate professor
Research specialty
• Nephrology clinical research; health care delivery research
Current research
• Impact of regionalization and program management on acute
care
• Impact of policy changes on the long term care sector
• Clinical trials on nephrology and hypertension
Past research
• Economic analysis of drug utilization
• Adverse effects of radio contrast media
BEAR, John C. Professor
Keywords
• Human genetics; epidemiology; demography; kidney; eye;
public health
Current research
• Genetic variation and the health of human populations
• Genetics of kidney disorders
• Genetic epidemiology of ocular refraction
Past research
• Genetic structure of the Newfoundland population
• Genetics of facial cleft malformations
BETHUNE, Cheri, Professor
Keywords
• Behavioural medicine, violence against women: wife assault
and sexual assault; patient-doctor communication; smoking cessation
Current research
• Patient-doctor communication
• Teaching behavioural medicine using information technology
Past research
• Teaching behavioural medicine
• Sexual assault
Potential research
• Smoking cessation strategies
BIEGER, Detlef Professor
Keywords
• Neuropharmacology; neuroanatomy; neurophysiology
Current research
• Neural control of deglutition and esophageal motility
• Characterization of neural function generators
• Neural and non-neural inhibitory processes in smooth muscle
• Photoactivation of NO donors
Past research
• Drug-induced dyskinesias
• Neural effects of psychotogens
• Serotonin-mediated functions related to upper alimentary
tract
BOWMER, M. Ian Professor
Keywords
• Infectious diseases
Current research
• Von Hippel Lindau syndrome: autosomal dominant inherited
disorder
• Medical education research
• HIV/AIDS clinical trials
Other research and consulting
• Accreditation process
• Chair: National working group on comprehensive clinical
care guidelines for HIV and AIDS
BROSNAN, John T. (see Biochemistry)
BROSNAN, Margaret (see Biochemistry)
BUCKLEY, David J. Assistant professor
Keywords
• Pediatric neurology; epilepsy; migraine; degenerative diseases
Current research
• Anticonvulsant medications in epilepsy
• Triptans in adolescent migraines
• Neuronal ceroid lipofuscinosis
Past research
• Vigabatrin in pediatric epilepsy
• EEG database for childhood epilepsy
Potential research
• Electroencephalographic features of pediatric brain tumours
• Childhood absence seizures
BUEHLER, Sharon K. Associate professor
Keywords
• Survey methodology; cancer public education; recruitment
strategies; cancer prevention
Current research
• Increasing continuing care: Developing strategies to reduce
non-urgent use of emergency services
• Breast cancer management in Newfoundland
• Explaining research to the public
• Factors influencing use of home care services by caregivers
of elderly persons
Past research
• Canadian study of health and aging (CSHA); CSHA-1; CSHA-Recontact;
CSHA-2
• Needs assessment: Newfoundland and Labrador Lung Association
• Randomized controlled trial of call/recall of hard-to-reach
women for Pap smears
CALLANAN, Terrence S. Associate professor
Keywords
• Mental health and legislation; service planning and evaluation;
psychotherapy training and evaluation
Current research
• Continuing professional development via distance and Internet
technology
• Interdisciplinary team building
Past research
• Mental health policy
• Legislative context of mental health and rehabilitation
services
Potential research
• Evaluation of psychotherapy training service development
and evaluation for individuals with personality disorders
CARAYANNIOTIS, George Professor
Keywords
• Experimental autoimmune thyroiditis; immunoregulation of
thyroid disease
Current research
• Animal models of thyroid disease
• Hypothyroidism
• Hypothyroidism, thyroglobulin, thyrotropin receptors
Special equipment or facilities
• HPLC (high pressure liquid chromatography), thermal cycler,
cell harvester
CHANDRA, Ranjit K. Professor
Keywords
• Immunology; nutrition; allergy; pediatrics; geriatrics
Current research
• Feeding formulas to boost immunity (e.g., animals and humans)
• Bifidobacteria, Immune responses, infection and allergy
• Nutrition and immunity in the elderly
Past research
• Hypoallergenic formulas and breast feeding for prevention
of allergies
• Iron status, cognitive function and immunity
• Zinc and thymulin
Potential research
• Single nutrient deficiencies and their impact on viral
and mycobacterial infection
CHEN, Xihua, Assistant Professor
Keywords
• patch clamp recording; synaptic transmission; parabrachial
nucleus;
dopamine.
Current research
• Cellular signaling underlying dopamine-induced synaptic
suppression in
the parabrachial nucleus
Past research
• Modulation of excitatory synaptic transmission by peptides,
opiates
and amines
Potential research
• Central actions of cocaine to activate the cardiovascular
system.
CHURCH, Elizabeth (see Counselling Centre)
CORBETT, Dale Professor
Keywords
• Cerebral ischemia; stroke; brain damage; memory; learning
Current research
• Cerebral ischemia and neuroprotection
• Postischemic hypothermia
• Pharmacological approaches for potential treatment of stroke
CRANE, Joan Assistant professor
Keywords
• Pre-term labour and birth; Induction of labour; prostaglandins
in obstetrics; Transvaginal ultrasound in obstetrics
Current research
• Misoprostol for labour induction
• Misoporstol in the management of the third stage of labour
• Transvaginal ultrasound in obstetrics
• Predictors of preterm birth
Past research
• Transvaginal ultrasound in the prediction of preterm birth
• Risk scoring, fetal fibronectin, and bacterial vaginosis
in prediction of preterm birth
• Oxytocin for labour induction
• Misoprostol for labour induction
• Maternal and neonatal outcomes with placenta previa
Potential research
• Induction of labour
• Management of third stage of labour
• Pre-term birth
CRELLIN, J.K. Professor
Keywords
• Self-care and alternative medicine; history of medicine
Current research
• Professionalism and alternative medicine
• History of therapy
Past research
• History of home medicine
• History of herbalism
Potential research
• Studies in traditional medicines
DROVER, Sheila Assistant professor
Keywords
• Immune recognition; breast cancer, rheumatoid arthritis,
major histocompatibility complex (MHC) antigens; antigen processing
and presentation; monoclonal antibodies
Current research
• Investigating whether different MHC molecules influence
the immune response in breast cancer patients
• Analysis of the antigen processing pathway in cells that
carry MHC molecules that are implicated in the development and
chronicity of rheumatoid arthritis
Past research
• Preparation and characterization of monoclonal antibodies
against MHC molecules
• Molecular analysis of structural determinants on MHC molecules
Potential research
• Identification of tumour associated antigens in breast
cancer
• Investigation of the immune response to autoantigens from
synovial tissue of rheumatoid arthritis patients
EATON, Bill Associate professor
Keywords
• Family coping
Current research
• House calls in Newfoundland
• Nutrition in long-term care
Past research
• Family, nurse, cancer patient perceptions of symptoms
Potential research
• Effectiveness of teaching methods
EDSTROM, Harry W. Professor
Keywords
• Pulmonary medicine; occupational medicine
Past research
• Occupational lung diseases: Baie Verte miners
• Occupational lung diseases: Labrador West dust study
• Clinical trial of volmax (sustained release selbutamol)
in the treatment of nocturnal asthma
FRIEL, James K. (see Biochemistry)
GILLESPIE, Laura Assistant professor
Keywords
• Growth factors; onocogenes; growth factor receptors; signal
transduction; neoplasia; cell differentiation; embryonic development;
Xenopus laevis; metastasis; gene expression
Current research
• Regulation and function of alternatively spliced forms
of the fibroblast growth factor (FGF) receptor
• Characterization of ER1: a novel FGF regulated, tumour-associated
gene
• Signal transduction by the FGF receptor during FGF-induced
cell differentiation
• Development of ER1 as a target for cancer therapy
Potential research
• Identification and analysis of FGF early response genes
• Regulation of cell migration and metastasis by FGF and
ER1
GRANT, Michael Assistant professor
Keywords
• Immunology of HIV infection; cytotoxic T cells
Current research
• Immunopathogenesis of HIV infection
• Development of immune-based therapies for HIV infection
• HIV/HCV co-infection
Past research
• Autoreactive cytotoxic T cells in HIV infection
• Autoantibodies against collagen in HIV infection
• Immune regulation
Potential research
• Immunopathogenesis of HCV infection
• Immunotherapy
GREEN, Jane Associate professor
Keywords
• Genetics; cancer genetics; natural history; genetic epidemiology;
genotype/phenotype correlations; Hereditary eye diseases
Research specialty
• Cancer genetics; ocular genetics
Current research
• Development, implementation and evaluation of clinical
and genetic screening programs for hereditary tumour syndromes
• Hereditary colon cancer: natural history, geographic distribution,
mutation analysis, and genotype and phenotype correlations
• Hereditary breast cancer: natural history, geographic distribution,
and mutation analysis
• Red-cone dystrophy linkage studies
Past research
• Bardet-Bidel syndrome; spectrum of disease, linkage analysis
(MRC, RP Foundation; Kidney Foundation)
• Hereditary eye disease; frequency, distribution in Newfoundland
(MRC; RP Foundation)
• Multiple Endocrine Neoplasia (Type I and II): Natural history
and mutation analysis (GHRF)
• Von-Hippel-Lindau disease: Development of screening programs
and linkage analysis
Potential research
• Genotype and phenotype correlations for hereditary tumour
syndromes
• Genetic epidemiology of hereditary cancers in Newfoundland
GREEN, Roger Associate professor
Keywords
• Genes; colorectal; breast cancer; DNA testing
Current research
• Genetic forms of colorectal and breast cancers
Past research
• Pre-symptomatic DNA testing
Potential research
• Molecular biology of other genetic diseases
HAEGERT, David Professor
Keywords
• Multiple sclerosis; genetic susceptibility; T-cell receptor
expression
Current research
• T-cell receptor repertoire in multiple sclerosis
• The use of DNA expression library to detect of autoantigens
in multiple sclerosis patients
• Autoantigens and tumour antigens in cancer of the uterine
cervix
Special equipment or facilities
• DNA thermal cyclers (2)
HAMILTON, Sean Associate professor
Keywords
• Rheumatology; medical education
Current research
• Affect of iron on the absorption of methotrexate in patients
with rheumatoid arthritis
Past research
• Comparison of two devices to measure grip strength in out-patient
rheumatology practice
Potential research
• Topics relating to medical education and the internal medicine
residency
HANRAHAN, Maura Assistant professor
Keywords
• Food security; food and culture; Aboriginal culture; Labrador
Métis society; Labrador; Aboriginal health; Newfoundland
culture; poverty; economic policy and community health
Current research
• Food security in Newfoundland and Labrador
• Aboriginal health concepts
• Food meanings in Aboriginal cultures
Past research
• Mega-project impacts in Labrador
• Newfoundland society and culture
• Fisheries policy and Newfoundland communities
• Poverty
Potential research
• Women's health concepts
• Women and food
HARLEY, Carolyn (see Psychology)
HARNETT, John D. Professor
Keywords
• Epidemiology; biometrics; dialysis; cardiac disease
Current research
• Baroreceptor dysfunction in chronic renal failure
• Clinical trials in renal transplantation
Past research
• Prognosis of heart disease in dialysis patients
• Risk factors of echocardiographic and clinical heart disease
in dialysis subjects
• Dialysis subjects
• Genetic basis of endstage renal disease
Potential research
• Telemedicine
HARRIS, June A. Associate professor
Keywords
• Medical education and evaluation
Current research
• Rating of pre-clerkship exams by postgraduate students
in terms of perceived relevance
• Medical school applicants with the admissions process
Past research
• Influence of study patterns on exam results experiences
for the study of anatomy
HERZBERG, Gene R. (see Biochemistry)
HOBEIKA, Chaker Associate professor
Keywords
• Pediatric asthma
Current research
• Efficacy; tolerability, and cost effectiveness of formoterol
tubuhalers ( 6 ug and 12 ug 6 i.d.) in six- to eleven-year-old
children with symptomatic asthma
Past research
• Asthma gene study, 1998
HOEKMAN, Theodore Associate professor
Keywords
• Medical informatics; clinical decision computer support;
medical education; computing support; electronic medical record;
structure and interface; pharmacology; muscular dystrophy
Current research
• Development of computer support tools for medical education
• Online interactive evaluation in CME using Web-based technologies
• Computerized clinical decision support systems, ‘smart'
clinical practice guidelines delivered via Web technology
• Developing a prototype for electronic patient record with
a Web interface
• Delivery of clinical practice algorithms via wireless connectivity
to handheld PDA computers
Past research
• Age dependent pathophysiology in avian hereditary muscular
dystrophy
• Affects of Phenytoin on the progression of avian muscular
dystrophy
• Abnormal pharmacologic properties of neuromuscular junction
in avian muscular dystrophy
Potential research
• Impact of computerized decision support on quality and
cost of health care
HURLEY, George (see Counselling Centre)
HUTCHINSON, Jim Assistant professor
Keywords
• Infectious diseases; epidemiology
Current research
• Antibiotic utilization in hospital and communities
• Antibiotic resistance determinants
• Clinical trials in therapy for pneumonia
Potential research
• Effects of health policy on treatment of infectious diseases
• Comparisons of international approaches to antibiotic control
Special equipment or facilities
• Molecular epidemiologic typing equipment (pulsed field
gel electrophoresis)
KAISER, Stephanie M. Associate professor
Keywords
• Cell and molecular biology; antisense technology; paranthyroid
hormone - related peptides; keratinocyte model, tumour progression
Current research
• Calcium regulating hormones, cellular growth and differentiation
• Osteoperosis
• Clinical research, lipid disorders
Past research
• Regulation of paranthyroid hormone-related peptides by
sex-steroid hormones
• Calcium hormones and osteoperosis, cervical keratinocyte
model of tumour progression
KAO, Kenneth Associate professor
Keywords
• Oncogenes; cell differentiation
Research specialty
• Developmental biology
Current research
• Formation of the nervous system
• Mechanisms of cell differentiation
• Oncogenes and development
Special equipment or facilities
• Confocal microscopy; molecular cloning; microsurgery
KEOUGH, Kevin M. W. (see Biochemistry)
KHRAISHI, Majed Associate professor
Keywords
• Rheumatoid arthritis; osteoarthritis; osteoporosis (therapeutics
and genetics); epidemiology of rheumatoid arthritis and osteoarthritis
Current research
• Rheumatoid arthritis therapeutics
• Osteoarthritis therapeutics
• Osteoporosis
KOVACS, Chris Assistant professor
Keywords
• Fetal-placental transfer; In situ hybridization; Immunohistochemistry;
PCR; Rt-PCR; northern; southern; western; animal physiology; small
animal surgery; intracellular calcium; radioimmunoassays; cell
cultures; electrophoresis; fetal injections; mice; knockout mice;
trasgenic mice; cell kinetics; plasmids; subcloning; transfection;
PTH; PTHrP; Vitamin D; Calcitriol; Calcitonin; CGRP; bone biopsies;
clinical trials
Current research
• Role of fetal parathyroid in regulating skeletal formation
and fetal-placental calcium transfer by utilizing an aparathyroid
knockout mouse model (Hoxa# knockout mice), a study
• Role of vitamin D (specifically calcitriol and the vitamin
D receptor) in regulating skeletal formation and fetal-placental
calcium transfer, by utilizing a vitamin D receptor gene knockout
mouse model, a study
• Studying the role of calcitonin and calcitonin gene-related
peptide (CGRP) in regulating skeletal formation and fetal-placental
calcium transfer, by utilizing a calcitonin gene knockout mouse
model, a study
Past research
• Examined and established the role of papathyroid hormone-related
protein (PTHrP) in maintaining the fetal blood calcium level,
and regulating fetal-placental calcium transfer (PTHrP knockout
mice)
• Studied role of the calcium sensing receptor (CaSR) in
regulating fetal-placental calcium metabolism, utilizing a CaSR
gene knockout model
• Studied breastfeeding and lactating women, establishing
that calcium homeostasis is altered in such women, partly due
to the effects of PTHrP secreted by the lactating breast
• Examination of the effectiveness of an insulin analogue
to treat diabetes (type 1 and 2), a clinical study
Potential research
• Effects of pregnancy and lactation on skeletal metabolism
in mice
• Further studies of fetal-placental calcium metabolism in
rodents, using normal and genetically-engineered mice that lack
or over-express a gene of interest to calcium metabolism
• Clinical trials, sponsored by the pharmaceutical industry,
of new medications for treating endocrinological diseases, such
as diabetes and osteoporosis
Special equipment or facilities
• Research Laboratory equipped for small animal studies,
radioactivity, cell cultures; knockout mice (currently six different
colonies and strains); ionized calcium machine; furnace for ashing
tissues; PCR; in situ hybridization; plan to obtain a small animal
bone densitometer
LARSEN, Bodil Associate professor
Keywords
• Immunogenetics; major histocompatibility complex (MHC);
complement; rheumatoid; arthritis
Current research
• Hormones and immune response
Past research
• Immunoglobulin and MHC genetics, myotonic dystrophy
• Complement genetics, multiple sclerosis
• Antibody formation in hedgehogs
LEFORT, Sandra M. (see Nursing)
LIU, Hu (see Pharmacy)
MACDONALD, Susan M. Assistant professor
Keywords
• Palliative medicine, symptom control (clinical)
Current research (all clinical trials)
• NMDA inhibitors in pain management.
• Omega 3-fatty acids in anorexia/cacchexia
Past research (clinical trials)
• Constipation in terminal illness
• Opioids in cancer pain
• Effect of new palliative care service
Potential research
• Nabalone in pain management
McLEAN, John Associate professor
Keywords
• Olfactory learning; brain development; regeneration
Current research
• Neurotransmitter interactions involved in learning in the
olfactory (smell) system
• Regeneration in the CNS following neurotrauma
Past research
• Alzheimer related research: viruses entering the brain
via the olfactory system
Potential research
• CNS repair following injury
• Enhanced learning
Special equipment or facilities
• Image analysis
MEAROW, Karen Associate professor
Keywords
• Neurobiology; neurotrophins; neuronal survival; neuritogenesis;
signal transduction in cultured primary, neurons molecular biology
Current research
• Neurotrophin signaling pathways associated with neuronal
survival
• Regulation of neurite growth in adult sensory neurons
• Use of adenoviral vectors to influence cell survival and
growth
Past research
• Regulation of peripheral nerve sprouting and regeneration
in vivo
• Molecular cloning and expression of enzymes involved in
glutamate metabolism in GNS astrocytes and neurons
Potential research
• Neurodegeneration
• CNS regeneration
MICHALAK, Thomas I. Professor
Keywords
• Viral hepatitis; viral persistence; molecular virology;
immunopathology; liver diseases; virus-induced autoimmunity; viral
hepatic carcinogenesis; immunotherapy; antivirals; animal models
of viral hepatitis
Current research
• Molecular immunopathogenesis of hepadnaviral persistence
• Mechanisms of liver injury in a noncytopathic virus infection
• Gene-based and immunomodulatory therapies against hepatitis
B
Past research
• Occult virus infection in healthy individuals convalescent
from hepatitis B
• Vertical transmittability of silent hepadnavirus infection,
from mothers to offspring
• Hepadnavirus, host cell receptor and plasma membrane interactions
• Hepadnavirus-induced, non-organ and liver-specific autoimmunity
• Ultrastructural characterization of hepatic hepatitis B
virus expression
• Immunopathogensis of vascular and kidney disorders associated
with chronic hepatitis B virus infection
Potential research
• Molecular pathogensis of virus-caused liver cancer
• Hepatitis C and HCV
• Evaluation of novel preventive and therapeutic strategies
against hepatitis B
• Novel animal models for viral hepatitis research
MOODY-CORBETT, Penny Professor
Keywords
• Developmental regulations for membrane excitability in
muscles and nerves
Current research
• Expression of voltage-regulated ion channels in nerves
and muscles
• Position of voltage-regulated ion channels relative to
synapses
• Changes in membrane excitability with development of strokes
Past research
• Acquisition of synaptic specializations
• Acetylcholine receptors and cholinesterase
• Myasthenia gravis
Potential research
• Expression of voltage-regulated ion channels in developing
skeletal muscle
• Regulation and modulation of expression of ion channels
in developing skeletal muscle
• Role of ion-channel distribution on membrane excitability
in central nervous system neurons
Special equipment or facilities
• Patch clamp amplifier, loose patch amplifier, phase contrast
microscopy, fluorescence microscopy
NEUMAN, Richard S. Professor
Keywords
• Neuropharmacology; neurophysiology; antidepressants; analgesia;
modulators
Current research
• Modulation of cortical excitability by endogenous mediators
Past research
• Serotonin and seizure suppression
• Hippocampal response to atypical antidepressants
Potential research
• Using navel compounds to reverse aging-related deficits
in cortical transmitter action
• Mechanisms of spinal analgesia
NEVILLE, Doreen Assistant professor
Keywords
• Health policy; health care delivery
Current research
• Evaluating the community development model for introducing
and diffusing heart health promotional activities
• Evaluation of the impact of the Canadian heart health initiative
on cardiovascular disease risk, morbidity and mortality for Canadians
Past research
• Evaluation of the impact of regionalization on mental health
services delivery
• The Newfoundland profile on the national health promotional
survey
• Socioeconomic inequities in cardiovascular risk status
in Canada - monograph
• Psychiatric emergency services delivery in St. John's:
Review of current service delivery mechanisms (with J. Maddigan)
• Lifetime costs and health consequences of an incident case
of major depressive disorder (with M. Weinstein)
• Impact of the national drunk driving campaign, U.S.A.(with
W. Evans, University of Maryland, and J. Graham, Harvard University)
• Evaluation of community-based services for the elderly;
alternatives to hospitalization
NGUYEN, Chau Assistant professor
Keywords
• Infectious diseases
Current research
• Treatment of pneumonia
Past research
• Studies on pneumonia
• Sepsis syndrome
• HIV infection in pregnant women
Potential research
• Infectious syndromes, clinical studies
OGUNYEMI, Abayomi Professor
Keywords
• Epilepsy; migraines
Current research
• Syndromes of epilepsy
• Epilepsy among the elderly
• Mechanisms of migraines; clinical and EEG correlation
Past research
• Triggered seizures by exercise, music
• Prevalence of headaches among university students
• Migraines with prolonged aura
• Cocaine and seizures
Potential research
• Post-stroke epilepsy
• Epilepsy and dementia
Special equipment or facilities
• Video-EEG telemetry
PARFREY, Patrick Research professor
Keywords
• Clinical epidemiology; nephrology; genetics; health care
delivery research
Current research
• Clinical epidemiology of end-stage renal disease
• Epidemiology of genetic diseases in Newfoundland
• Restructuring of health care delivery
Past research
• Cardiac disease in clinical uremia
• Genetic renal disease
• Assessment of radiology context media
PATER, Alan Professor
Keywords
• Cancer virology; Human papillomaviruses; hormones; molecular
biology; apoptosis; gene expression; immortalization; transformation;
oncogenic progression; drug resistance; telomerase; carcinogens;
organotypic culture; nude mouse implants
Current research
• (See above)
Past research
• JC virus, differentiation
Potential research
• Drug delivery
PATERNO, Gary D. Associate professor
Keywords
• Molecular biology of cancer; regulation of embryotic development
Current research
• Role of growth factors in cancer
• Development of gene targets as therapeutic approaches to
disease
Potential research
• DNA vaccines in cancer treatment
PULLMAN, Daryl Associate professor
Keywords
• Medical ethics
Current research
• Informed consent
• Health beliefs and values
• Pain and suffering: human dignity
Past research
• Ethics of autonomy and dignity
• End-of-life decision-making
• Research ethics
Potential research
• Genetic research
• Fetal rights
• Justice in health care
PRYSE-PHILLIPS, William Professor
Keywords
• Stroke; dementia; multiple sclerosis epidemiology; Newfoundland
Current research
• Alzheimer disease therapy
• Alzheimer disease epidemiology
• Multiple sclerosis genetic and epidemiology studies
• Familial ataxia, a genetic study
Past research
• Epidemiology of multiple sclerosis in Newfoundland
• Study of familial carpal tunnel syndrome
• Myotonic dystrophy
• Alzheimer disease precensors: clinical trials in Alzheimer
disease
• Acute headache therapy
• Acute stroke therapy
RAHMAN, Proton Assistant professor
Keywords
• Genetic epidemiology of complex disease; prognosis studies
in rheumatic diseases
Current research
• Linkage studies in autoimmune disease
• Pharmacogenetics
• Prognosis studies in psoriatic arthritis
Past research
• C.A.D. in SUE
• Radiology in rheumatic diseases
Potential research
• Gene-environment interaction
• Association-based studies in genetics
RAWSON, Nigel Professor
Keywords
• Pharmaceoepidemiology, especially with administrative health
care databases; outcome research; pharmaceutical policy
Current research
• Study of two classes of anti-arrhythmia agents
• Comparison of new drug approval times: Canada, Australia,
Sweden, the U.K. and the U.S.
• Methods of listing drugs on provincial formularies in Canada,
focusing on effectiveness
Past research
• Approaches to evaluating the validity of data, Saskatchewan
administrative health care utilization datafiles
• Evaluation of an adverse event signaling method, based
on the Saskatchewan administrative health care utilization datafiles
• Incidence of aplastic anemia and agranulocytosis, association
with prior prescription drug use, Saskatchewan
Potential research
• Use and outcomes of medications
• Study of adverse affects of drugs
• Policies for the availability and use of drugs
RICHARDSON, Vernon Associate professor
Keywords
• Immunology; cancer; vaccines; cytokine and chemokines;
anti-cancer drug development
Current research
• Signalling pathways in monocytes and macrophages
• Quillaja saponins and adjurant development
• Cytokine and chemokine regulation of matrix metally proteases
• Development of thiopyridyl triazine as potential anti-cancer
drugs
Past research
• RNA-tumour viruses: liposomes, HSV vaccine development
• Plant virology, antibody drug targeting, ISCOMS
• Chemotaxis model development
ROBBINS, Carl Professor
Keywords
• Telemedicine
Current research
• Remote community services, telecentres
Past research
• Labrador telemedicine project
Potential research
• Newfoundland and Labrador emergency medicine network
ROSALES, T.O. Associate professor
Keywords
• Clinical genetics; phenotypes, a definition; adopted and
foster children; child neglect and abuse; FAS/FAE/ARND/ARBD
Current research
• FAS/FAE/ARND/ARBD
• Exceptional children
• Clinical phenotypes of neurocutaneous disorders
Past research
• Benign familial neonatal seizures
• 46XY partial dysgenesis
• Bone marrow transplant in metachromatic leukodystrophy
Potential research
• Impact of clinical genetics on reproduction
• Utilization of genetics services by medical professionals
• Effectiveness of a clinical genetic service
Special equipment or facilities
• Medical genetics program, clinic
• Molecular diagnostic Laboratory
• Cytogenetic Laboratory
SCULLY, Mary-Frances Assistant professor
Keywords
• Hematology; management of hemophilia and hereditary bleeding
disorders;
management of thrombosis and hyper-coagulable states; leukemia
management
Current research
• Thrombosis interest groups in Canada, a Web site, (TIGC.org)
• Epideminology molecular biology of hemophilia in Newfoundland
and Labrador
• Audit of anticoagulation practices in Newfoundland and
Labrador
• Treatment of acute mycloid leukemia
Past research
• Investigator for the Children's Cancer Group (CCG)
• Investigator for the Canadian Childhood Platelet study
• Investigator for the Association of Hemophilia Clinic Directors
of Canada
Potential research
• Epideminology of stem cell disorders in Newfoundland and
Labrador
• Optimal management of anticoagulation in a rural setting
• Investigation into a wellness care model (chemotherapy
for people with acute leukemia)
SEGOVIA, Jorge Professor
Keywords
• Sociomedical sciences; health services research; health
status measurement; health surveys
Current research
• The association among health status, health practices,
and medical care utilization, using a longitudinal design model
• Study of high users of hospital services in Newfoundland
• Development of algorithms to study patterns of care
Past research
• Lifestyle, health practices and medical care utilization
• Study of health practices and medical care utilization
in St. John's
• A medical care utilization master sample for Newfoundland
Potential research
• Longitudinal study of medical care utilization in Newfoundland
• High users of medical care services
• Assessment of community participation in primary care
TABRIZCHI, Reza Associate professor
Keywords
• Basic pharmacology
Current research
• Effect of drugs on cardiac output and vascular resistance
• Vascular, smooth muscle and drug-receptor interactions
• Signal transduction
Past research
• Pharmacology of venous circulation
• Haemorrhage and venous circulation
• Pheripheral circulation
Potential research
• Vascular pharmacology and physiology in hypertension
TANG, Shou-Ching Assistant professor
Keywords
• Molecular regulation of Apoptosis; prognostic factors in
breast and lung cancers; clinical trials of new chemotherapeutic
agents
Current research
• Molecular characterization of BAG-1 in apoptosis.
• Prognostic value of BAG-1 in breast and lung cancers
• Use of BAG-1 in the treatment of human malignancies
Potential research
• MAB, gene therapy in cancer
THOMAS, Roger Professor
Keywords
• Systematic reviews and meta-analysis; prevention of smoking
by children and adolescents
Current research
• Prevention of smoking in children and adolescents
• Systematic reviews of randomized, controlled trials for
smoking prevention among adolescents and children
• Travel medicine
Past research
• Neonatal infection
• Problem-based learning
• Tuberculosis
VAN VLIET, Bruce N. Assistant professor
Keywords
• Autonomic control; cardiovascular system
Current research
• Baroreflex
• Baroreflex dysfunction
• Blood pressure control
Past research
• Role of baroreflex to stabilize cardiac energy expenditure
• Role of blood pressure variability in hypertensive damage
• Obesity-induced hypertension
Special equipment or facilities
• Blood pressure telemetry system
WALLEY, Robert Professor
Keywords
• Maternal mortality and obstetric fistula, in developing
countries and crisis situations
Current research
• Development, implementation and evaluation of an emergency
model, obstetrical service in rural Ghana, West Africa
• Evaluation of misoprostol for the management of life threatening
postpartum haemorrhage for use by traditional birth attendants
in rural areas of Africa
• Development of a birth trauma centre in Ghana, West Africa
Past research
• Maternal mortality and morbidity in Nigeria
Potential research
• See above
WANG, Xikui Assistant professor
Keywords
• Biostatistics; statistical decision theory
Current research
• Clinical trials: ethics, statistical designs and analysis
• Statistical decision theory, Markov decision processes
• Survival analysis, statistics in medicine and cancer studies
Past research
• Probability theory, conditional expectations
• Functional analysis
Potential research
• Medical economics
• Meta-analysis, sequential statistics, Bayesian statistics
• Stochastic processes
WAY, Christine (See Nursing)
WEST, Roy Professor, associate dean
Keywords
• Population-based epidemiology; Pharmaceoepidemiology; Communicable
disease control; Health policy
Current research
• Association between nsaids and diverticular disease
• Influenza surveillance and control
• Pharamacoepidemiologic studies
Potential research
• Health information systems, used in record linkage studies
• Primary health care, especially disease prevention and
health promotion
WHITE, Hubert Associate professor
Keywords
• Child and adolescent psychiatry
Current research
• Use of Paroxetine (PaxilR) in children and adolescents
with obsessive-compulsive disorder (OCD)
• Use of Risperidone among children with pervasive developmental
disorders
• Bone density in adolescents with anorexia nervosa
Past research
• Telemedicine-child telepsychiatry, a project
• Use of Risperidone in developmentally-delayed, aggressive
children
• Outcomes in children and adolescents with Tourette's disorder
Potential research
• Telepsychiatry
• Drug trials in adolescent depression
Special equipment or facilities
• Telemedicine unit
WORRALL, Graham Associate professor
Keywords
• Diabetes; depression; dementia; herpes labialis; clinical
practice guidelines; functional assessment
Current research
• Functional assessments of elderly patients
• Clinical guidelines for Type II diabetes
• Clinical guidelines for depression
Past research
• Cognitive function and Type II diabetes
• Repair of skin lacerations
• Family doctor attitudes towards clinical guidelines
• Management of herpes labialis
Potential research
• Standardized functional assessment of elderly people, a
controlled trial
• Management strategies for youth behaviour disorders
XIE, Yagang Assistant professor
Keywords
• Human genetics; cancer; mutation analysis; hemophilia;
genetic mapping
Current research
• Identifying the mutation of Factor VII gene, associated
with a high incidence of hemophilia A in Newfoundland, and the
gene-frequency determination
Past research
• Oculopharyngeal muscular dystrophy, genetic mapping, physical
mapping, positional cloning, characterizing, novel gene, mutation
screening
• Neurofibrosis Type 2, physical mapping, positional cloning,
characterizing novel gene, mutation screening
• Human genome project, physical mapping of human chromosome
22
• Chromosome trisomy 18, parental origin
Potential research
• Mutation analysis and genotype, and phenotype correlation
of human genetic diseases (e.g., Cystic fibrosis, Pallister-Hall
syndrome, multiple endocrine neoplasia type 2, a study)
YOUNGHUSBAND, Banfield Associate professor
Keywords
• Cancer; genetics; immunology
Current research
• Hereditary eye disease
• Hereditary colon cancer
Past research
• Structural proteins
• Gene cloning, sequencing
• Adenovirus
Potential research
• Human genetic diseases
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