Lung Surfactant Function and Disorder

Edited by Dr. Kaushik Nag

Lung Surfactant Function and Disorder

Lung Surfactant Function and Disorder

The only source to describe the lung surfactant as a complex membranous system, this guide analyzes lung surfactant function from the aspects of molecular biology, bio-physics, membrane science, and surface and interface analysis and reviews the latest basic and clinical issues relating to lung disease and (dys)function.

Each chapter is written by contributors at the forefront of the field and covers state-of-the art methodologies to detect and analyze the biomolecular structure - function properties of surfactants in areas including single-molecule analysis, mass spectrometry, atomic force microscopy, genetic-knockout systems and microbiology.

In 19 authoritative chapters, this handbook addresses standard, novel and controversial issues and alternative views of surfactant function. It also supplies comprehensive listings of references through 2004, discusses methods used to determine the molecular dynamics and nanoscale, supramolecular and single-molecular organization of membranous systems as applied to the lung surfactant. The book also contains diverse experimental protocols of methods such as NMR, AFM, TOF-SIMS, mass spectrometry, single-channel recording, computer modeling, genetic-knockout, and colloidal and surface analysis. The authors describe the structure-function relationship of the lung surfactant in normal and disease or (dys)functional states. It also comprehensively assesses techniques for the study of membranes, surfactant and bio-colloidal surfaces and interfaces including Langmuir-Blodgett films, bubble imaging, atomic force microscopy, TOS-SIMS, and Raman and FTIR spectroscopy and studies the physiology and pathology of molecular mechanisms at the lung gas-water interface.

Dr. Kaushik Nag

Dr. Kaushik Nag

Kaushik Nag is assistant professor of biochemistry and physics at Memorial University. He is also a new investigator (2002-07) for the Canadian Institute of Health Research. His research focuses on surfactant inhibition in lung disease, the biophysical challenges associated with membranes and the modeling of systems in relation to the lung surfactant. He obtained his M. Sc. and PhD in biochemistry from Memorial before becoming a professor at the university.