FACULTY OF SCIENCE

BIOCHEMISTRY COURSE LIST

In accordance with Senate's Policy Regarding Inactive Courses, courses which have not been offered in the previous three academic years and which are not scheduled to be offered in the current academic year have been removed from the following listing. For information about any of these inactive courses, please contact the Head of the Department.

1430. Biochemistry for Nurses. An introduction to the chemistry and structure-function relationships of carbohydrates, lipids and proteins. Basic metabolism of carbohydrates and fats, with emphasis on the biochemical fluctuations that occur in human health and disease. A brief introduction to molecular genetics. This course may not be used for credit to fulfil the requirements for a major in the Department of Biochemistry. Entry into this course is restricted to students in the BN (Collaborative) Program. Prospective fast-track program students should consult with the School of Nursing concerning admission to this course.
Prerequisite: Level 3 Chemistry or Chemistry 1010 or Chemistry 1810 or equivalent.
Lectures: Four hours per week
NOTE: Credit may be obtained for only one of Biochemistry 1430 and the former 2430.

2000. Principles of Food Science. This course enables one to gain an understanding of the scope of Food Science as a discipline. Topics include introductions to chemistry, processing, analysis, microbiology, packaging, product development, sensory evaluation and quality control as they are related to Food Science.
Prerequisite: Chemistry 2400 or 2440.
Lectures: Three hours per week.
Laboratory: One period per week.

2010. Introductory Foods I. An introduction to the science of food and food preparation. Topics covered include fats and oils, simple and complex carbohydrates, fruits and vegetables, cereals and starches. Laboratory work applies scientific principles and theories to practical problems in food preparation.
Prerequisite: Chemistry 1011 or 1051.
Lectures: Three hours per week.
Laboratory: Three hours per week.

2011. Introductory Foods II. An introduction to the science of food and food preparation. Topics covered include proteins - dairy products, eggs, meats and fish, legumes, gelatin and flour proteins, batters and doughs, meal management and menu planning. Laboratory work applies scientific principles and theories to practical problems of food preparation.
Prerequisite: Chemistry 1011 or 1051; Biochemistry 2010.
Lectures: Three hours per week.
Laboratory: Three hours per week.

2100. Introduction to Molecular Biology and Genetics. From phenotype to genotype: this course will cover the heritability of simple traits; the discovery of DNA as the molecule of heredity; the structure and function of DNA; the elucidation of the genetic code; and the manipulation of DNA for recombinant DNA technology and biotechnology.
Prerequisites or corequisites: Biochemistry 2101, Chemistry 2401, Physics 1021 or 1054. Students may replace the corequisite Chemistry 2401 with Chemistry 2440 as a prerequisite. Chemistry 2440 may not be taken as a corequisite of 2100.
Lectures: Three hours per week.
Laboratory: Three hours on alternate weeks.

2101. Introduction to Biochemistry. An introduction to the major organic substances of living organisms, proteins, carbohydrates and lipids: their structure, analysis and biochemical function. Enzymes. Biochemistry of membranes: plasma membrane and specialized intracellular membranes. Biochemistry of selected differentiated cells.
Prerequisites: Chemistry 2400, 2401 or Chemistry 2440; and Physics 1020, 1021 or 1050, 1054. Chemistry 2401 and Physics 1021 or 1054 can be done concurrently.
Lectures: Three hours per week.
Laboratory: One three-hour laboratory period on alternate weeks to illustrate concepts covered in the lectures.
NOTE: Credit may be obtained for only one of 2101, 3100, or Pharmacy 3110.

2600. Introduction to Human Nutrition. (Same as HKR 2600). This course gives an overview of human nutrition with an emphasis on topics of current interest. Students will gain an understanding of nutrition in the context of health maintenance across the life span. Topics covered will include nutrition during pregnancy, nutrition for infants, Canadian Recommended Nutrient Intakes / Dietary Reference Intakes, weight loss and weight gain, nutriceuticals and ergogenic aids.
NOTE: (i) Credit can be received for only one of Biochemistry 2600, Kinesiology 2600.
(ii) Students who have completed Biochemistry 3200 or 3201 may not subsequently receive credit for Biochemistry 2600.
(iii) Students may not count Biochemistry 2600 among the 60 credit hours in Biochemistry courses required for Honours in Biochemistry, Honours in Nutrition, or Honours in Dietetics.

3054. Fundamentals of Food Microbiology. An introduction to the basic principles of microbiology with an emphasis on the study of microorganisms that are found in foods. The role of microbes in food and food spoilage, and the role of food-borne pathogens in human illness and disease will each be discussed. Nutritional aspects of food-borne microorganisms will also be studied.
Lectures: Three hours per week.
Prerequisites: Biology 1002 and Biochemistry 2101.
NOTE: Credit can only be received for only one of Biochemistry 3052, 3054, Biology 3052, and the former Biochemistry 3401.

3105. Physical Biochemistry. Types of intermolecular forces in biomolecules. The folding of biomolecules and the role of water. PH, buffers, and ionisation of biomolecules. Thermodynamics: equilibria, coupled reactions, transport across membranes and redox reactions. Ligand binding. Size and shape of biomolecules. Isotopes in biochemistry. Spectroscopy of biomolecules.
Prerequisites: Biochemistry 2101; and Chemistry 2300 or Physics 2053.
Lectures: Three hours per week and a two hour problem-solving class.

3106. Metabolism. The catabolism of carbohydrates, lipids and amino acids. Mitochondria, chloroplasts and ATP synthesis. Biosynthesis of carbohydrates and lipids. Metabolic specialization of differentiated cells and tissues. Integration of metabolism.
Prerequisite: Biochemistry 2101.
Lectures: Three hours per week.
Practical classes: One three-hour laboratory or one-hour tutorial per week.
NOTE: Credit may be obtained for only one of Biochemistry 3106, the former Biochemistry 3102 or Pharmacy 3111.

3107. Nucleic Acid Biochemistry and Molecular Biology. The structure, function and biochemistry of DNA and RNA and the biochemical processes in the flow of information from the gene to protein. These will include: DNA replication, recombination and repair processes; transcription of RNA and RNA splicing; and protein synthesis. The regulation of gene expression will also be covered at an introductory level. The course will also include an introduction to cloning methodology.
Prerequisite: Biochemistry 2101; and Biochemistry 2100 or Biology 2250.
Lectures: Three hours per week.
Laboratory: Up to four hours per week which will normally consist of one three hour laboratory period plus one additional hour on the following day.

311A and 311B. Human Physiology. (Same lectures as Medicine 310A and 310B. This course is taught and administered by the Faculty of Medicine.) Topics covered include the properties of nerves and muscle cells, the nervous system, the special senses, blood and body fluids, the cardiovascular system, the gastrointestinal tract, respiration, renal function, endocrinology and reproduction. Integration of the body's systems in maintaining homeostasis will be emphasized.
Prerequisite or Corequisite: Biochemistry 2101.
Lectures: Three hours per week.
Laboratory: To be specified.
Priority for entry into this course will be given to Biochemistry, Nutrition, Dietetics, and other students who are interested in experimental science.
NOTE: Credit may be obtained for only one of Biochemistry 311A/B or Medicine 310A/B.

3200. Basic Human Nutrition I. A study of the nutrients essential to human health and well-being with emphasis on carbohydrates, proteins and lipids-chemistry, dietary source, dietary requirements, metabolism, physiological importance.
Prerequisite or Corequisite: Biochemistry 2101 or Pharmacy 3110.
Lectures: Three hours per week.

3201. Basic Human Nutrition II. A study of the vitamins, minerals and trace elements essential to human health and well-being - chemistry, dietary source, dietary requirements, physiological role, deficiency syndromes.
Corequisite or prerequisite: Biochemistry 3106 or Pharmacy 3111.
Lectures: Three hours per week.

3202. Community Nutrition. Nutritional assessment, nutrition education, and the role of community agencies and individuals in the dissemination of nutritional information. Survey methods and results will be discussed.
Co-requisites or prerequisites: Biochemistry 311B and 3201.
Prerequisite: Biochemistry 3200.
Lectures: Three hours per week.
NOTE: Credit may be obtained for only one of Biochemistry 3202 and the former Biochemistry 4302.

3402. Food Chemistry. Water structure and the role of water in chemical reactions and mechanical properties of foods. Chemistry and physical properties of carbohydrates, proteins and lipids. Food dispersions. Pigments and natural colorants. Food flavour. Enzyme properties and applications. Vitamins and minerals. Chemistry of enzymic and non-enzymic browning. Characteristics of: muscle tissue, milk, eggs, bread and edible plant tissue. Food additives. Chemical changes in foods during processing.
Prerequisites: Biochemistry 2000 and Biochemistry 2101.
Lectures: Three hours per week.
Laboratory: One period per week.

4002. Biochemical Regulation. Control theory. Metabolic regulation at the cellular and multicellular level. Hormones: their biosynthesis and mechanism of action. Signal transduction. Endocrine coordination of metabolic processes. Principles will be illustrated by the use of case studies from the medical and veterinary literature.
Prerequisites: Biochemistry 2100 or Biology 2250; Biochemistry 3106.
Lectures: Two to three hours per week, together with assigned reading and case studies.

4101. Proteins. Review of history of protein research and general properties of proteins. Strategy and methods for purification. Chemical structure, properties, modification and determination of the protein amino acids. Sequencing strategy, chain cleavage methods and end group analysis. Folding of the protein main chain and techniques to determine structure. The relationship between structure and function: protein filaments, motors and regulators. Disease-related proteins and other examples from the current literature.
Prerequisite: Biochemistry 3105.
Lectures: Two to three hours per week and assigned reading.

4102. Current Topics in Biochemistry. A seminar course in which faculty and students will discuss topics of current interest in the biochemical literature. Students will be responsible for reading and critically assessing recent literature.
Prerequisites: Admission to this course is restricted to Honours Biochemistry students in their final year or by permission of the Head.

4103. Prokaryotic Gene Regulation. A detailed and up-to-date treatment of the mechanisms of genetic regulation found in bacterial cells. The course will develop topics based on the evidence of bacterial genetics and modern molecular biological experiments. Topics may include: theory of mutations, RNA transcription, positive and negative regulation of transcription; regulation of protein synthesis; control of DNA replication; bacterial operons and regulons; developmental molecular biology in bacterial systems; and evolution and molecular biology of organelles.
Prerequisite: Biochemistry 3107.
Lectures: Three hours per week.

4104. Eukaryotic Gene Regulation and Developmental Biology. This course will detail the cellular and molecular aspects of eukaryotic gene regulation and development. Topics to be covered will include the DNA content and organization of eukaryotes, mechanisms controlling the expression of eukaryotic genetic information at the transcriptional and post-transcriptional levels, and the methodologies used to define these mechanisms. Detailed consideration will be given to the cell-surface events which regulate nuclear gene expression and cell lineage specification. Developmental mechanisms operating in a number of model systems will be discussed.
Prerequisite: Biochemistry 3107.
Lectures: Three hours per week.

4105. Immunology. (Same as Pharmacy 4105. This course is taught and administered by the School of Pharmacy). Introduction to the molecular and cellular basis of immunity and hypersensitivity. Discussion of the manipulation of the immune system in the management and treatment of disease.
Lectures/Tutorials: Three per week.
Prerequisites/Co-requisites: Biochemistry 2101, 311B.
NOTE: Credit may be obtained for only one of Biochemistry 4105, Pharmacy 4105 and the former Pharmacy 3105.

4200. Bioenergetics and Biological Oxidation. Respiration and electron transport. Functional organization of energy transducing membranes. The structure and function of flavoenzymes, cytochromes, iron-sulfur proteins and quinones. Enzyme reduction of oxygen. Free radicals in biological systems.
Prerequisite: Biochemistry 3106.
Lectures: Two to three hours per week and assigned reading.

4201. Membranes - Structure, Function and Biosynthesis. The biosynthesis of the different components of biological membranes. The structure of model and biological membranes, the molecular interactions between membrane components and the effects of these interactions on the biophysical and functional properties of membranes. Transport of molecules across biological membranes. The transport of lipids by plasma lipoproteins and their role in certain diseases.
Prerequisite: Biochemistry 3106.
Lectures: Two to three hours per week and assigned reading.

4210. Biochemical Research Techniques I. A course designed to familiarize students with methods used for the study of structural and molecular biology.
Prerequisites: Biochemistry 3105, 3107.
Lectures and laboratory periods: times as arranged.
Attendance is required.

4211. Biochemical Research Techniques II. A course designed to familiarize students with methods used for the study of cellular and subcellular metabolism. This course may include a research project.
Prerequisite: Biochemistry 3106.
Lectures and laboratory periods: times as arranged.
Attendance is required.

4220. Introduction to General and Autonomic Pharmacology. (Same as Medicine 4300). This course will deal with the general principles of pharmacology (receptors, absorption, distribution, metabolism, pharmacokinetics) drugs affecting peripheral nerve transmission and the cardiovascular system.
Prerequisites: Biochemistry 3106, 311A, 311B.
Lectures: Three hours per week.
Laboratory: Three hours per week.
NOTE: Credit may be obtained for only one of Biochemistry 4220 or Medicine 4300.

4300. Nutrition in the Life Cycle. Nutritional considerations throughout the life cycle, with particular emphasis on infant, maternal, and geriatric nutrition.
Prerequisites: Biochemistry 311B, 3200, 3201.
Lectures: Three hours per week.

4301. Nutrition and Disease. A course which addresses the scientific basis for nutritional intervention in chronic human disease.
Prerequisites: Biochemistry 311A/B, 3200/3201.
Lectures: Biochemistry 311B, 3200/3201.

4502. Current Topics in Nutrition. A seminar course in which faculty and students will discuss topics of current interest in the area of nutrition. Students will be responsible for reading and critically assessing recent literature.
Prerequisite: Biochemistry 4301.
Admission to this course is restricted to Honours Nutrition students in their final year or by permission of the head.

499A/499B. Dissertation. A two-semester linked course (6 credit hours) based on independent study of a problem in Biochemistry. The subject of study will be decided in consultation with Faculty advisors and must be approved in advance by the Department, or both Departments in the case of a Joint Honours degree. This dissertation is obligatory for Honours students in Biochemistry. The dissertation will be submitted as a formal written report accompanied by appropriate illustration before the end of the tenth week of the second semester. Before the end of his/her final semester the student will give an oral presentation of his/her research. Admission to this course is restricted to Honours students in their final year or by permission of the Head.
NOTE: Credit may be obtained for only one of Biochemistry 499B or Biochemistry 4999.

4999. Dissertation. A three-credit hour dissertation for Honours students in Dietetics and Nutrition. The dissertation will be based on independent study of a problem in Dietetics or Nutrition. The subject of study will be decided in consultation with Faculty advisors and must be approved in advance by the Department. The dissertation will be submitted as a formal written report accompanied by appropriate illustrations before the end of the semester. Admission to this course is restricted to Honours students in their final year or by permission of the Head.
NOTE: Credit may be obtained for only one of Biochemistry 499B or Biochemistry 4999.


Last modified on June 4, 2003 by R. Bruce

Up to Calendar Table of Contents

Back to Office of the Registrar's Home Page