In accordance with Senate's Policy Regarding Inactive Courses, courses which have not been offered in the previous three academic years and which are not scheduled to be offered in the current academic year have been removed from the following listing. For information about any of these inactive courses, please contact the Head of the Department.
1430. Biochemistry for Nurses. An introduction to the
chemistry and structure-function relationships of carbohydrates, lipids
and proteins. Basic metabolism of carbohydrates and fats, with emphasis
on the biochemical fluctuations that occur in human health and disease.
A brief introduction to molecular genetics. This course may not be used for
credit to fulfil the requirements for a major in the Department of Biochemistry.
Entry into this course is restricted to students in the BN (Collaborative)
Program. Prospective fast-track program students should consult with the
School of Nursing concerning admission to this course.
Prerequisite: Level 3 Chemistry or Chemistry 1010 or Chemistry 1810 or
equivalent.
Lectures: Four hours per week
NOTE: Credit may be obtained for only one of Biochemistry 1430 and the
former 2430.
2000. Principles of Food Science. This course enables
one to gain an understanding of the scope of Food Science as a discipline.
Topics include introductions to chemistry, processing, analysis, microbiology,
packaging, product development, sensory evaluation and quality control as
they are related to Food Science.
Prerequisite: Chemistry 2400 or 2440.
Lectures: Three hours per week.
Laboratory: One period per week.
2010. Introductory Foods I. An introduction to the science
of food and food preparation. Topics covered include fats and oils, simple
and complex carbohydrates, fruits and vegetables, cereals and starches.
Laboratory work applies scientific principles and theories to practical
problems in food preparation.
Prerequisite: Chemistry 1011 or 1051.
Lectures: Three hours per week.
Laboratory: Three hours per week.
2011. Introductory Foods II. An introduction to the science
of food and food preparation. Topics covered include proteins - dairy products,
eggs, meats and fish, legumes, gelatin and flour proteins, batters and doughs,
meal management and menu planning. Laboratory work applies scientific principles
and theories to practical problems of food preparation.
Prerequisite: Chemistry 1011 or 1051; Biochemistry 2010.
Lectures: Three hours per week.
Laboratory: Three hours per week.
2100. Introduction to Molecular Biology and Genetics.
From phenotype to genotype: this course will cover the heritability of simple
traits; the discovery of DNA as the molecule of heredity; the structure
and function of DNA; the elucidation of the genetic code; and the manipulation
of DNA for recombinant DNA technology and biotechnology.
Prerequisites or corequisites: Biochemistry 2101, Chemistry 2401, Physics
1021 or 1054. Students may replace the corequisite Chemistry 2401 with Chemistry
2440 as a prerequisite. Chemistry 2440 may not be taken
as a corequisite of 2100.
Lectures: Three hours per week.
Laboratory: Three hours on alternate weeks.
2101. Introduction to Biochemistry. An introduction to
the major organic substances of living organisms, proteins, carbohydrates
and lipids: their structure, analysis and biochemical function. Enzymes.
Biochemistry of membranes: plasma membrane and specialized intracellular
membranes. Biochemistry of selected differentiated cells.
Prerequisites: Chemistry 2400, 2401 or Chemistry 2440; and Physics 1020,
1021 or 1050, 1054. Chemistry 2401 and Physics 1021 or 1054 can be done
concurrently.
Lectures: Three hours per week.
Laboratory: One three-hour laboratory period on alternate weeks to illustrate
concepts covered in the lectures.
NOTE: Credit may be obtained for only one of 2101, 3100, or Pharmacy
3110.
2600. Introduction to Human Nutrition. (Same as HKR 2600).
This course gives an overview of human nutrition with an emphasis on topics
of current interest. Students will gain an understanding of nutrition in the
context of health maintenance across the life span. Topics covered will include
nutrition during pregnancy, nutrition for infants, Canadian Recommended Nutrient
Intakes / Dietary Reference Intakes, weight loss and weight gain, nutriceuticals
and ergogenic aids.
NOTE: (i) Credit can be received for only one of Biochemistry 2600,
Kinesiology 2600.
(ii) Students who have completed Biochemistry 3200 or 3201 may not subsequently
receive credit for Biochemistry 2600.
(iii) Students may not count Biochemistry 2600 among the 60 credit hours
in Biochemistry courses required for Honours in Biochemistry, Honours in
Nutrition, or Honours in Dietetics.
3054. Fundamentals of Food Microbiology. An introduction
to the basic principles of microbiology with an emphasis on the study of
microorganisms that are found in foods. The role of microbes in food and
food spoilage, and the role of food-borne pathogens in human illness and
disease will each be discussed. Nutritional aspects of food-borne microorganisms
will also be studied.
Lectures: Three hours per week.
Prerequisites: Biology 1002 and Biochemistry 2101.
NOTE: Credit can only be received for only one of Biochemistry 3052,
3054, Biology 3052, and the former Biochemistry 3401.
3105. Physical Biochemistry. Types of intermolecular
forces in biomolecules. The folding of biomolecules and the role of water.
PH, buffers, and ionisation of biomolecules. Thermodynamics: equilibria,
coupled reactions, transport across membranes and redox reactions. Ligand
binding. Size and shape of biomolecules. Isotopes in biochemistry. Spectroscopy
of biomolecules.
Prerequisites: Biochemistry 2101; and Chemistry 2300 or Physics 2053.
Lectures: Three hours per week and a two hour problem-solving class.
3106. Metabolism. The catabolism of carbohydrates, lipids
and amino acids. Mitochondria, chloroplasts and ATP synthesis. Biosynthesis
of carbohydrates and lipids. Metabolic specialization of differentiated
cells and tissues. Integration of metabolism.
Prerequisite: Biochemistry 2101.
Lectures: Three hours per week.
Practical classes: One three-hour laboratory or one-hour tutorial per week.
NOTE: Credit may be obtained for only one of Biochemistry 3106, the
former Biochemistry 3102 or Pharmacy 3111.
3107. Nucleic Acid Biochemistry and Molecular Biology.
The structure, function and biochemistry of DNA and RNA and the biochemical
processes in the flow of information from the gene to protein. These will
include: DNA replication, recombination and repair processes; transcription
of RNA and RNA splicing; and protein synthesis. The regulation of gene expression
will also be covered at an introductory level. The course will also include
an introduction to cloning methodology.
Prerequisite: Biochemistry 2101; and Biochemistry 2100 or Biology 2250.
Lectures: Three hours per week.
Laboratory: Up to four hours per week which will normally consist of one
three hour laboratory period plus one additional hour on the following day.
311A and 311B. Human Physiology. (Same lectures as Medicine
310A and 310B. This course is taught and administered by the Faculty of
Medicine.) Topics covered include the properties of nerves and muscle cells,
the nervous system, the special senses, blood and body fluids, the cardiovascular
system, the gastrointestinal tract, respiration, renal function, endocrinology
and reproduction. Integration of the body's systems in maintaining homeostasis
will be emphasized.
Prerequisite or Corequisite: Biochemistry 2101.
Lectures: Three hours per week.
Laboratory: To be specified.
Priority for entry into this course will be given to Biochemistry, Nutrition,
Dietetics, and other students who are interested in experimental science.
NOTE: Credit may be obtained for only one of Biochemistry 311A/B or
Medicine 310A/B.
3200. Basic Human Nutrition I. A study of the nutrients
essential to human health and well-being with emphasis on carbohydrates,
proteins and lipids-chemistry, dietary source, dietary requirements, metabolism,
physiological importance.
Prerequisite or Corequisite: Biochemistry 2101 or Pharmacy 3110.
Lectures: Three hours per week.
3201. Basic Human Nutrition II. A study of the vitamins,
minerals and trace elements essential to human health and well-being - chemistry,
dietary source, dietary requirements, physiological role, deficiency syndromes.
Corequisite or prerequisite: Biochemistry 3106 or Pharmacy 3111.
Lectures: Three hours per week.
3202. Community Nutrition. Nutritional assessment, nutrition
education, and the role of community agencies and individuals in the dissemination
of nutritional information. Survey methods and results will be discussed.
Co-requisites or prerequisites: Biochemistry 311B and 3201.
Prerequisite: Biochemistry 3200.
Lectures: Three hours per week.
NOTE: Credit may be obtained for only one of Biochemistry 3202 and
the former Biochemistry 4302.
3402. Food Chemistry. Water structure and the role of
water in chemical reactions and mechanical properties of foods. Chemistry
and physical properties of carbohydrates, proteins and lipids. Food dispersions.
Pigments and natural colorants. Food flavour. Enzyme properties and applications.
Vitamins and minerals. Chemistry of enzymic and non-enzymic browning. Characteristics
of: muscle tissue, milk, eggs, bread and edible plant tissue. Food additives.
Chemical changes in foods during processing.
Prerequisites: Biochemistry 2000 and Biochemistry 2101.
Lectures: Three hours per week.
Laboratory: One period per week.
4002. Biochemical Regulation. Control theory. Metabolic
regulation at the cellular and multicellular level. Hormones: their biosynthesis
and mechanism of action. Signal transduction. Endocrine coordination of
metabolic processes. Principles will be illustrated by the use of case studies
from the medical and veterinary literature.
Prerequisites: Biochemistry 2100 or Biology 2250; Biochemistry 3106.
Lectures: Two to three hours per week, together with assigned reading and
case studies.
4101. Proteins. Review of history of protein research
and general properties of proteins. Strategy and methods for purification.
Chemical structure, properties, modification and determination of the protein
amino acids. Sequencing strategy, chain cleavage methods and end group analysis.
Folding of the protein main chain and techniques to determine structure.
The relationship between structure and function: protein filaments, motors
and regulators. Disease-related proteins and other examples from the current
literature.
Prerequisite: Biochemistry 3105.
Lectures: Two to three hours per week and assigned reading.
4102. Current Topics in Biochemistry. A seminar course
in which faculty and students will discuss topics of current interest in
the biochemical literature. Students will be responsible for reading and
critically assessing recent literature.
Prerequisites: Admission to this course is restricted to Honours Biochemistry
students in their final year or by permission of the Head.
4103. Prokaryotic Gene Regulation. A detailed and up-to-date
treatment of the mechanisms of genetic regulation found in bacterial cells.
The course will develop topics based on the evidence of bacterial genetics
and modern molecular biological experiments. Topics may include: theory
of mutations, RNA transcription, positive and negative regulation of transcription;
regulation of protein synthesis; control of DNA replication; bacterial operons
and regulons; developmental molecular biology in bacterial systems; and
evolution and molecular biology of organelles.
Prerequisite: Biochemistry 3107.
Lectures: Three hours per week.
4104. Eukaryotic Gene Regulation and Developmental Biology.
This course will detail the cellular and molecular aspects of eukaryotic
gene regulation and development. Topics to be covered will include the DNA
content and organization of eukaryotes, mechanisms controlling the expression
of eukaryotic genetic information at the transcriptional and post-transcriptional
levels, and the methodologies used to define these mechanisms. Detailed
consideration will be given to the cell-surface events which regulate nuclear
gene expression and cell lineage specification. Developmental mechanisms
operating in a number of model systems will be discussed.
Prerequisite: Biochemistry 3107.
Lectures: Three hours per week.
4105. Immunology. (Same as Pharmacy 4105. This course
is taught and administered by the School of Pharmacy). Introduction to the
molecular and cellular basis of immunity and hypersensitivity. Discussion
of the manipulation of the immune system in the management and treatment
of disease.
Lectures/Tutorials: Three per week.
Prerequisites/Co-requisites: Biochemistry 2101, 311B.
NOTE: Credit may be obtained for only one of Biochemistry 4105, Pharmacy
4105 and the former Pharmacy 3105.
4200. Bioenergetics and Biological Oxidation. Respiration
and electron transport. Functional organization of energy transducing membranes.
The structure and function of flavoenzymes, cytochromes, iron-sulfur proteins
and quinones. Enzyme reduction of oxygen. Free radicals in biological systems.
Prerequisite: Biochemistry 3106.
Lectures: Two to three hours per week and assigned reading.
4201. Membranes - Structure, Function and Biosynthesis.
The biosynthesis of the different components of biological membranes. The
structure of model and biological membranes, the molecular interactions
between membrane components and the effects of these interactions on the
biophysical and functional properties of membranes. Transport of molecules
across biological membranes. The transport of lipids by plasma lipoproteins
and their role in certain diseases.
Prerequisite: Biochemistry 3106.
Lectures: Two to three hours per week and assigned reading.
4210. Biochemical Research Techniques I. A course designed
to familiarize students with methods used for the study of structural and
molecular biology.
Prerequisites: Biochemistry 3105, 3107.
Lectures and laboratory periods: times as arranged.
Attendance is required.
4211. Biochemical Research Techniques II. A course designed
to familiarize students with methods used for the study of cellular and
subcellular metabolism. This course may include a research project.
Prerequisite: Biochemistry 3106.
Lectures and laboratory periods: times as arranged.
Attendance is required.
4220. Introduction to General and Autonomic Pharmacology.
(Same as Medicine 4300). This course will deal with the general principles
of pharmacology (receptors, absorption, distribution, metabolism, pharmacokinetics)
drugs affecting peripheral nerve transmission and the cardiovascular system.
Prerequisites: Biochemistry 3106, 311A, 311B.
Lectures: Three hours per week.
Laboratory: Three hours per week.
NOTE: Credit may be obtained for only one of Biochemistry 4220 or Medicine
4300.
4300. Nutrition in the Life Cycle. Nutritional considerations
throughout the life cycle, with particular emphasis on infant, maternal,
and geriatric nutrition.
Prerequisites: Biochemistry 311B, 3200, 3201.
Lectures: Three hours per week.
4301. Nutrition and Disease. A course which addresses
the scientific basis for nutritional intervention in chronic human disease.
Prerequisites: Biochemistry 311A/B, 3200/3201.
Lectures: Biochemistry 311B, 3200/3201.
4502. Current Topics in Nutrition. A seminar course in
which faculty and students will discuss topics of current interest in the
area of nutrition. Students will be responsible for reading and critically
assessing recent literature.
Prerequisite: Biochemistry 4301.
Admission to this course is restricted to Honours Nutrition students in
their final year or by permission of the head.
499A/499B. Dissertation. A two-semester linked course
(6 credit hours) based on independent study of a problem in Biochemistry.
The subject of study will be decided in consultation with Faculty advisors
and must be approved in advance by the Department, or both Departments in
the case of a Joint Honours degree. This dissertation is obligatory for
Honours students in Biochemistry. The dissertation will be submitted as
a formal written report accompanied by appropriate illustration before the
end of the tenth week of the second semester. Before the end of his/her final
semester the student will give an oral presentation of his/her research.
Admission to this course is restricted to Honours students in their final
year or by permission of the Head.
NOTE: Credit may be obtained for only one of Biochemistry 499B or Biochemistry
4999.
4999. Dissertation. A three-credit hour dissertation
for Honours students in Dietetics and Nutrition. The dissertation will be
based on independent study of a problem in Dietetics or Nutrition. The subject
of study will be decided in consultation with Faculty advisors and must be
approved in advance by the Department. The dissertation will be submitted
as a formal written report accompanied by appropriate illustrations before
the end of the semester. Admission to this course is restricted to Honours
students in their final year or by permission of the Head.
NOTE: Credit may be obtained for only one of Biochemistry 499B or Biochemistry
4999.
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