Dr. Marcel Florin Musteata
School of Pharmacy
Dr. Marcel Musteata joined the School of Pharmacy in April 2007, following education and work experience in the field of pharmaceutical analysis and pharmacokinetics. He earned his pharmacy degree in Romania in 1998 and worked for a year as a community pharmacist before becoming an academic instructor. He taught pharmaceutical analysis (laboratory) for three years in Romania before moving to Ontario to do a PhD at the University of Waterloo in pharmaceutical analysis as applied for pharmacokinetic studies.
While at the University of Waterloo, he developed novel sampling and analysis techniques for in vivo pharmacokinetic studies. He continued his research in pharmaceutical analysis as a postdoctoral fellow at the University of Toronto. He brings a new research expertise to the School of Pharmacy, and is involved in teaching graduate and undergraduate courses in pharmacokinetics and pharmaceutical analysis as well as setting up a research laboratory.
The need for new analytical devices for fast medical diagnostics is experiencing a growing trend. Dr. Musteata said point-of-care devices for measuring electrolytes, cardiac markers, and several small molecules now reside in nursing stations, surgical suites, emergency rooms, and even at patient bedsides. At the same time, there has been a significant expansion of uses of physiologically based pharmacokinetic (PBPK) modeling in areas related to environmental chemicals and drugs. However, little has been done to develop analytical tools that address the specific needs of PBPK models; analytical data for such pharmacokinetic models are still difficult to obtain. To meet these growing needs, the main directions of Dr. Musteata’s research are the development of miniaturized technology for in vivo and in vitro drug analysis and application of modern analytical techniques to advance physiologically based pharmacokinetic models.
Dr. Musteata explained these research directions have a significant impact on the study of ligand-receptor interactions, fast determination of plasma protein binding, determination of drug concentration in tissues, simultaneous assay of free and total drug concentration in whole blood or serum, and determination of blood flow rate, with the ultimate goal of providing proper drug dosage regimens for all patients.