Fixation of alleles with weak selective disadvantage in finite populations
Trajectories of a weakly deleterious (s = -0.005)
rare mutant allele in multiple populations (N = 100 @)
from an
initial fA = 1/200 = 0.005.
Most replicates go to fA =
0 within fifty generations: one goes to fixation at ~
230 generations, despite the absence of any selective
advantage. Another drifts almost to fixation against
selection, but eventually goes to f(A) = 0 as
expected. Notice that this graph is quite similar to that
for a rare weakly advantageous allele.
HOMEWORK: Find the expected trajectories of weakly advantageous & disadvantageous alleles from the deterministic GSM model).
HOMEWORK: Find the expected trajectories of weakly advantageous & disadvantageous alleles from the deterministic GSM model).
Text material © 2021 by Steven M. Carr