MGA2-11-18Wyrobek et al 2006

Increasing risk of Trisomy-21 (Down Syndrome) with age of mother

    Women who conceive in their late 40s have as much as a 50-fold higher risk than women in their 20s of having a child with Down Syndrome (left). Some question exists as to whether the age of the father influences this trend. Analysis of chromosome X-Y-21 aneuploidy in sperm (right) shows no significant association with age  (Wyrobek et al. 2006 PNAS 103, 9601)

Figure ©2002 by Griffiths et al.; all text material ©2014 by Steven M. Carr