IG1_07_10

Molecular basis of Huntington Disease:

Tri-nucleotide
(CAG) repeats in the gene locus lead to runs of Gln in HD protein. Onset and severity are correlated with the number of repeats, with variable penetrance beginning at ca. 40 repeats.


Figure 2012 TA Brown, Introduction to Genetics (1st ed.); additional text 2013 by Steven M. Carr