Dicentric chromosomes
Breakage of the DNA molecule
in two non-homologous
chromosomes can produce "sticky ends" that recombine end-to-end. The
ends of the chromosomes are lost as acentric fragments.
In a metaphase chromosome spread, these appear as a single
chromosome
with two centromeres. At
mitosis, the centromeres will segregate together
and produce segmental aneuploidy.
All
text
material © 2007 by Steven M. Carr