Bio4241 - Final exam questions, 2016
Tuesday, 12 April,
9-11A, Sn-1019
Instructions:
I will select five of the following questions.
Answer any three: you may not answer the
question pertaining to your own group's presentation. Your
answers for each must fit on the front and back of one
lined sheet of paper.
See Supporting
Materials for figures that will be
available during the exam
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SMC: With reference
to Figure 1.1 in Gibson (2015), compare and
contrast the Mendelian Model versus the Infinitesimal
Model as explanations for human genetic diseases. How
do the RAME and CD-CV Models
differ from the two main models?
Group 1 – The Human Genome Project has identified
exactly 20,051 "genes" in the human genome.
Why is this number unexpected? Describe some of the reasons
humans are able to get by with so few "genes."
SMC - Explain the
concepts of Most Recent
Common Ancestor and Coalescence
in terms of the "Mitochondrial Eve".
Group 2 – Sketch the
historical origins and spread of indigenous Africans,
Europeans, East Asians, and North and South Americans. Why
do anthropologists talk about "Continental Groups"
rather than "Races" ?
Group 3 - Height
is historically one of the most highly Heritable
human traits. Describe the basis in "normal genetic
variation" of variation in height as revealed by the
Human Genome Project. How can this variation be reconciled
with its classical heritability?
Group 5 –
Explain the nature of a Genome-Wide Association
Study (GWAS). In Figure 6.1,
describe the principles features of the WTCCC GWAS studies
as illustrated for Type 2 Diabetes
Group 6 & 7 –
Explain the construction of Genetically
Modified Organisms (GMOs), specifically ABT's GMO
Salmon. Compare the stated commercial advantages of GMO
Salmon with respect to other GMO species,
for example Round-Up ready corn.
SMC: Explain the
difference between the concept of Heritability
and Mendelian inheritance. Answer the question at [http://www.mun.ca/biology/scarr/Biol4241_Heritability_&_Environment.html]
All text material ©2016 by Steven M. Carr