Hypothetical indel mutations in the mtDNA
cytochrome b gene of the Moose
5'-ttc ggt tct cta tta gga gtt
tgc tta atc tta gaa atc -3'
F G S L L G V C L I L E I
Moose+1 5'-ttc ggt tct cta tta
Tgg agt ttg ctt aat ctt aga
aat c -3'
F G S L L W S L L N L *
Moose-1 5'-ttc ggt tct cta ttaVgag ttt gct taa tct tag aaa tc -3'
F G S L L E F A *
Moose+2 5'-ttc ggt tct cta tta
TTg gag ttt gct taa tct tag
aaa tc -3'
F G S L L L E F A *
Moose-2 5'-ttc ggt tct cta ttaV agt ttg ctt aat ctt aga aat c -3'
F G S L L S L L N L *
Moose+3 5'-ttc ggt tct cta tta
tta gga gtt tgc tta atc tta
gaa atc -3'
F G S L L L G V C L I L E I
Moose-3 5'-ttc ggt tct cta ttaVgtt tgc tta atc tta gaa atc -3'
F G S L L V C L I L E I
Line 1 shows the reading frame of standard Moose sequence, with 5th, 6th, & 7th triplets highlighted.
Lines 2 & 3
show a single-nucleotide insertion
(T) or deletion (g) at the sixth
Lines 4 & 5 show a double-nucleotide insertion (TT) or deletion (gg) at the sixth triplet.
Lines 6 & 7 show a triplet insertion (TTA) or deletion (gga) of the sixth triplet.
An indel of 1 or 2
nucleotides alters the reading frame, such that the polypeptide
sequence is altered, and a premature stop triplet is
generated at random
An indel of 3 nucleotides
leaves the reading frames unchanged, such that a single amino
acid is inserted or deleted.
Only the sense DNA strand is shown. Amino acids are given in the single-letter code: the mtDNA code is slightly different from the "universal" code.