
Did Mendel "cheat" ?
Analysis
of
Mendel's data has led to speculation about the accuracy and
completeness of his reported results, and led to a perennial
question,
Did Mendel Cheat?
(1) Statistical analysis of the
ratios
reported in Mendel's 1866 paper suggest they are "too good:"
they
conform more closely to the predicted 3:1 ratio than would be
expected
given the number of observations. This has led to suggestions
that
Mendel selectively presented only those data that best
supported his
hypothesis, or even fabricated the data outright. An
alternative
explanation is that Mendel may have observed a ratio close to
3:1 in
early counts, and thereafter continued counting until he felt
confident
that a genuine 3:1 had been obtained. Researchers nowadays
would
pre-determine the number of seeds to be counted, but such
statistical
sophistication was not available in the the 1860s.
(2) Mendel
worked
with seven genes, and Pisum
has seven
pairs of chromosomes. It is highly improbable that seven
randomly-chosen genes would each occur on a separate
chromosome.
Dihybrid crosses involving genes on the same chromosome would
have shown linkage,
which
would have been unexplainable by Mendel's
rules. [Remember
that
chromosomes were unknown in the 1860s].
Therefore, it is
concluded, he
must have thrown out some dihybrid results
that didn't fit his rules.
In fact, the seven genes map to only four
chromosomes, and only two of these are close enough to
show
linkage
disequilibrium. Since there are (7)(7-1)/2
= 21 possible dihybrid
crosses, and Mendel reported results from only a few of these
(not
including the linked pair), there is no basis on which to
doubt the
accuracy and completeness of his dihybrid results.