Dr. Daisy Sahoo - July 19

HDL and scavenger receptors: A love-hate relationship

The interaction of high density lipoprotein (HDL) with its receptor, scavenger receptor BI (SR-BI) is critical for lowering plasma cholesterol levels and reducing the risk for cardiovascular disease. The HDL/SR-BI interaction facilitates delivery of cholesterol into cells and is likely mediated by receptor dimerization. Today’s seminar will describe: (1) the importance of cholesterol clearance from the body via proper SR-BI/HDL interactions; (2) the use of nuclear magnetic resonance techniques (NMR) to generate the first high-resolution structure of the C-terminal transmembrane domain of SR-BI, a region that harbors a leucine zipper dimerization motif, that when mutated, impairs the ability of SR-BI to bind HDL and mediate cholesterol delivery; and (3) how oxidized forms of HDL are dysfunctional and promote cardiovascular disease through interactions with the scavenger receptor, CD36.

Contact

Biochemistry

230 Elizabeth Ave

St. John's, NL A1B 3X9 CANADA

Tel: (709) 864-2530

Fax: (709) 864-2552

becomestudent@mun.ca